DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17739 and SPON2

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_001121797.2	Gene:	SPON2 / 10417	HGNCID:	11253	Length:	331	Species:	Homo sapiens

Alignment Length:	304	Identity:	106/304 - (34%)
Similarity:	148/304 - (48%)	Gaps:	31/304 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CCACDEAKYELTFEGKWSRHTHPKDFPANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAE 244
            |.|...|||.:||.||||:...||.:|......::|.::||:|:.||..|:..:..|.|||:.||
Human    35 CSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAE 99

  Fly   245 HGSTRTLESELKDQSEHIRTIIKA-RGIAYPNVTGKTFAVFRVDSNHHLISLVSMVDPSPDWIVG 308
            .|....|..|::...|.::::... ...|.|:.||:|.|...|...|.|:|.|..:.|||||.||
Human   100 RGEAWALMKEIEAAGEALQSVHAVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVG 164

  Fly   309 VSGLELCLPNCSWVENKVHNLYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDP 373
            |..|:|| ....|.|....:|||:|||||||.::.|.:...:|.|.|..|.|:.|:.|.:.||.|
Human   165 VDSLDLC-DGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYP 228

  Fly   374 TGAQMKPLATLHINRRR------------LYEKNCESSDSEQVPP---ECATNSWSRWDECTTKC 423
            ....:.|:|.:.:.|.|            |..::.|..||..||.   :|..:.||.|..|...|
Human   229 RLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHC 293

  Fly   424 GP-GKQYRIREFK-NPALASRHRCNNA-----LREEKNCVGHKC 460
            |. |.:.|.|..: .||       ||.     |.||..||...|
Human   294 GRLGTKSRTRYVRVQPA-------NNGSPCPELEEEAECVPDNC 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081
		Spond_N	186..373	CDD:283999	73/187 (39%)
		TSP1	412..460	CDD:214559	18/54 (33%)
		TSP1	490..541	CDD:214559
		KU	661..715	CDD:294074
		TSP_1	815..862	CDD:278517
SPON2	NP_001121797.2	Spond_N	41..228	CDD:399462	73/187 (39%)
SPON2	NP_001121797.2	TSP1_spondin	278..330	CDD:408798	19/58 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850