DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and RPA135

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_015335.1	Gene:	RPA135 / 856119	SGDID:	S000006214	Length:	1203	Species:	Saccharomyces cerevisiae

Alignment Length:	1276	Identity:	368/1276 - (28%)
Similarity:	568/1276 - (44%)	Gaps:	270/1276 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IKPLTEKWKLVPAFLQVKGLVKQHIDSFN--------HFINVDIK----KIV-------KANELV 73
            |.|..:|    .||..::..|:.||.|||        ..:|:.:|    |::       ..:|:.
Yeast    26 INPPKDK----SAFPLLQEAVQPHIGSFNALTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEDEIS 86

  Fly    74 TSGADPLFYLKYL---------DVRVGKPDIDDGFN--ITKATTPHECRLRDTTYSAPITVDIEY 127
            .||        ||         .|.:.||..:||.:  :.:...|.|.|.|.|:|...:.:.:::
Yeast    87 NSG--------YLGNKLSVSVEQVSIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGKLLLKLKW 143

  Fly   128 T--RGTQRIKRNNLL----IGRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVI 186
            :  .|.:     ||.    .|.:|:||:.:.|.|...|.:||.:..|...:.||||:|.|.||:|
Yeast   144 SVNNGEE-----NLFEVRDCGGLPVMLQSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLI 203

  Fly   187 --LIQEQLSW----------NKMLTEDFNGVVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTD 239
              ||.::.:.          |:..:....|:   |:.|...::.|:|.||     :||....:|.
Yeast   204 RMLIVQRRNHPMAIIRPSFANRGASYSHYGI---QIRSVRPDQTSQTNVL-----HYLNDGQVTF 260

  Fly   240 D---------IPIVVIFKALGVVSDQEI-QSLIGIDSKSQNRFGASLIDAYNL----------KV 284
            .         :|:|:|.|||...||:|| ..:||.|.|.     :.|.|...|          .:
Yeast   261 RFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKD-----SFLTDRLELLLRGFKKRYPHL 320

  Fly   285 FTQQRALEYMGSKLVVKRFQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRRVM 349
            ..:.:.|:|:|.|..|. ||::..::..|..:|:|...:|.|:..|  ..|.|...:..|:|::.
Yeast   321 QNRTQVLQYLGDKFRVV-FQASPDQSDLEVGQEVLDRIVLVHLGKD--GSQDKFRMLLFMIRKLY 382

  Fly   350 AAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDVVKHMR 414
            :....:...|:.|...::.:.|.|.|..|:.::........:......:|.:..|..|...::|.
Yeast   383 SLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEYLQNIIAQVRMDINRGMAINFKDKRYMS 447

  Fly   415 AA------QITAGLESAISSGNWTIKR-FKMER-AGVTQVLSRLS---YISALGMMTRVNSQFEK 468
            ..      .|.:.::..:|:||...:. ..::: :|.|.|..:::   :||...|:.|  ..|..
Yeast   448 RVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHR--GSFFA 510

  Fly   469 TRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEE-RPVMIVAFNAGVEDIRE 532
            ..|.:..|.|.|..||.|||..||:|..|||:.:.|....|:|:..: ..:..:.::.||   ..
Yeast   511 QLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGV---AP 572

  Fly   533 VSGNPINNPNVFLVFINGNVLGLTLNH---KHLVRNLRYMRRKGRMG--------SYVSVHTSYT 586
            .|......|::..|.|:|.::| .::|   |.:...|||.:.:|:..        .||...|...
Yeast   573 ASHTFAAGPSLCCVQIDGKIIG-WVSHEQGKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQ 636

  Fly   587 QRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIA 651
            ...:|:.....|:.||          |:...||:        :|.:  |..|.:.:|      ||
Yeast   637 YPGLYLFGGHSRMLRP----------VRYLPLDK--------EDIV--GPFEQVYMN------IA 675

  Fly   652 WNEDQIEDRT-THLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSL 715
            ....:|::.. ||:|..|..:|.:.|.|.|:...||||||.|||.||||.||..|....:|.|:.
Yeast   676 VTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNK 740

  Fly   716 MYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYK 780
            :|.|.....|:||:...:....|..|.|.||.|||:||:|||::||:|:||::.:||:|...:||
Yeast   741 LYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTGYDMDDAMIINKSADERGFGYGTMYK 805

  Fly   781 NSKCTVKRYANQTFDRIMGPMKDALTNKVIFKHD--------VLDTDGIVAPGEQVQNKQIM--- 834
            ..|..:....|:         .|.:|....|.:|        .||.||:...|..|:....:
Yeast   806 TEKVDLALNRNR---------GDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICAY 861

  Fly   835 ----INKEMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDF----LIKILL 891
                :||                    |.:. :|...||:|||.|.:..:....|    .:.|..
Yeast   862 FDDTLNK--------------------TKIK-TYHSSEPAYIEEVNLIGDESNKFQELQTVSIKY 905

  Fly   892 RQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGK 956
            |..|.|:||||||||||||||........||||::.||.||:|:|||.||||||:|..:|.|.||
Yeast   906 RIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLAGK 970

  Fly   957 AGLLEGKFHYGTAFGGSKVEDIQA-----ELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQ 1016
            ||.|.|.....|.:..:: :|..|     :|.:.|:||.|.:..|||.||..|.|.||.|.||||
Yeast   971 AGALHGIAQDSTPWIFNE-DDTPADYFGEQLAKAGYNYHGNEPMYSGATGEELRADIYVGVVYYQ 1034

  Fly  1017 KLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAF 1081
            :|:|||.||...|:.||...||.||.:||.|.||:|:||||||.||.:|.|.|:.:||:.|||..
Yeast  1035 RLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYT 1099

  Fly  1082 EVDVCRTCGRM--------------AYCSWCHFCQSSANVSK----------------------- 1109
            :..|||.||.:              ..|  |..|......:|
Yeast  1100 QASVCRECGSILTTQQSVPRIGSISTVC--CRRCSMRFEDAKKLLTKSEDGEKIFIDDSQIWEDG 1162

  Fly  1110 -------------ISMPYACKLLFQELTSM------NVVPK 1131
                         :::|:..|.|..||::|      ||.||
Yeast  1163 QGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNVEPK 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	366/1270 (29%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	363/1257 (29%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	44/179 (25%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	17/71 (24%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	10/40 (25%)
RPA135	NP_015335.1	RpoB	23..1203	CDD:223163	366/1274 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810