DRSC/TRiP Functional Genomics Resources

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Protein Alignment: RpIII128 and POLR3B

Sequence 1:NP_523706.1 Gene:RpIII128 FlyBaseID:FBgn0004463 Length:1137 Species:Drosophila melanogaster
Sequence 2:NP_060552.4 Gene:POLR3B HGNCID:30348 Length:1133 Species:Homo sapiens

Alignment Length:1117 Identity:772/1118 (69%)
Similarity:929/1118 (83%) Gaps:6/1118 (1%)


  Fly    25 SVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYLDVR 89
            :.||..:.|||:|:||||:|||||||||||||:||||:||||:||||.|||.|||::|||||::.
Human    17 AAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIY 81

  Fly    90 VGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRIKRNNLLIGRMPLMLRCSNCA 154
            ||.||:::.||:|:..:||||||||.|||||||||||||||:|||.||.|.|||||:|||.|||.
Human    82 VGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCV 146

  Fly   155 LTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLTE-DFNGVVQCQVTSSTHEKK 218
            ||||:..|.:|||||||||||||:|:|.|||||||||||.|:::.| |..|.|...|||||||||
Human   147 LTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKK 211

  Fly   219 SRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLIGIDSKSQNRFGASLIDAYNLK 283
            |||.:..|.|::||:||::::|||||:||||:||.|||||..:||.:......||.||.:....:
Human   212 SRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQ 276

  Fly   284 VFTQQRALEYMGSKLVVKR-FQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRR 347
            :|||.:||:|:|:|:..:| :.....||..|||||||.:|||.||||..||.:.|.||.::||||
Human   277 IFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRR 341

  Fly   348 VMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDVVKH 412
            |:.|:.|..: |||||||||||||||.|||::||||||:.|.|:|.|||:.|||.:|||||||||
Human   342 VILAQGDNKV-DDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKH 405

  Fly   413 MRAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRS 477
            ||..|||.|:.:|||:|||::|||||:|.||||||||||||||||||||::||||||||||||||
Human   406 MRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRS 470

  Fly   478 LQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEERPVMIVAFNAGVEDIREVSGNPINNPN 542
            ||||||||||||||||||||||||||||||||||::|:.|::.:|.|.||||:..:.|..::.||
Human   471 LQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPN 535

  Fly   543 VFLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVE 607
            |||||:|||:||:..:||.||...|.|||.|.:..:||:.|:.|.||:||.:|||||||||:||:
Human   536 VFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK 600

  Fly   608 NRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTHLEIEPFTLL 672
            .::|.|...|::||.:|.|.|:|||.:.|:||||||||||..||..|..|...||||||||||||
Human   601 KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLL 665

  Fly   673 GVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNF 737
            ||||||:|||||||||||||||||||||||.|||||:||||:|||.|.||..||||:|||||..|
Human   666 GVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF 730

  Fly   738 DKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMK 802
            :||||||||||||||||||||||||:|||||:|||:||||||||:|||:|||.|||||::||||.
Human   731 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPML 795

  Fly   803 DALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSA--QVPYTAVPISYK 865
            ||.|.|.|::|::||.|||.:|||:|:|||:::||.||.||.: ||:|.:.  |..|..|||:||
Human   796 DAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQI-PLEGSNVPQQPQYKDVPITYK 859

  Fly   866 GPEPSYIERVMVSANAEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGIC 930
            |...||||:||:|:|||:.||||:||||||.||||||||||||||||.||||.||||||.|.|||
Human   860 GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGIC 924

  Fly   931 PDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAFGGSKVEDIQAELERHGFNYVGKDFF 995
            ||:|||||||||||||||.:|||.||||:|:|:||||||||||||:|:..:|.|||:||:|||:.
Human   925 PDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYV 989

  Fly   996 YSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDC 1060
            .|||||.|||||||.||||||||||||.||||||||||:||||||||:||||:||||||||||||
Human   990 TSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC 1054

  Fly  1061 LISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCSWCHFCQSSANVSKISMPYACKLLFQELTS 1125
            ||.||||||::|||||||||||||||..||.:.|..|||:|:||.:||.:.:|||||||||||.|
Human  1055 LIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS 1119

  Fly  1126 MNVVPKMILENY 1137
            ||::|::.|..|
Human  1120 MNIIPRLKLSKY 1131

Known Domains:


GeneSequenceDomainRegion External IDIdentity
RpIII128NP_523706.1 PRK08565 34..1135 CDD:236291 768/1105 (70%)
RNA_pol_B_RPB2 47..1133 CDD:238353 757/1090 (69%)
RNA_pol_Rpb2_2 210..370 CDD:282427 88/161 (55%)
RNA_pol_Rpb2_4 546..607 CDD:282431 35/61 (57%)
RNA_pol_Rpb2_5 628..668 CDD:282432 26/40 (65%)
POLR3BNP_060552.4 RNA_pol_B_RPB2 39..1127 CDD:238353 757/1090 (69%)
RNA_pol_Rpb2_4 539..600 CDD:309626 35/61 (57%)
RNA_pol_Rpb2_5 621..661 CDD:309627 26/40 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 C55632547
eggNOG 1 0.900 E1_COG0085
Hieranoid 1 1.000
Homologene 1 1.000 H6981
Inparanoid 1 1.050 1588 1.000 Inparanoid score I84
Isobase 1 0.950 0 Normalized mean entropy S207
OMA 1 1.010
OrthoDB 1 1.010 D42570at2759
OrthoFinder 1 1.000 FOG0003638
OrthoInspector 1 1.000 T1072613
orthoMCL 1 0.900 OOG5_126694
Panther 1 1.100 LDO PTHR20856
Phylome 1 0.910 0.667 Consistency score
RoundUp 1 1.030 avgDist Average_Evolutionary_Distance R1190
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
1514.750

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