Protein Alignment RpIII128 and POLR2B

DIOPT Version :9

• Sequence 1: NP_523706.1
• Gene: RpIII128 / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: NP_000929.1
• Gene: POLR2B / 5431
• HGNCID: 9188
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1169
• Identity: 436/1169 - (37%)
• Similarity: 686/1169 - (58%)
• Gaps: 93/1169 - (7%)

  Fly    35 WKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIV--------KANELVTSG---ADPLFYLKYLDV 88
            |.::.::...||||:|.:|||:.||.:.:::||        :|.....||   ..|.:.||:..:
Human    27 WIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQI 91

  Fly    89 RVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYT---RGTQRI--KRNNLLIGRMPLML 148
            .:.||...:.........|:|.|||:.|||||:.|||..|   .|.:::  :.....||::|:||
Human    92 YLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIML 156

  Fly   149 RCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLT---ED----FNGVV 206
            |.:.|.|.|.::.:|.:||||||||||||::.|.|||::.||:::.|.:..   :|    :.|
Human   157 RSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTG-- 219

  Fly   207 QCQVTSSTHEKKSRTL---VLSKHGK---------------YYLKHNSMTDDIPIVVIFKALGVV 253
            :|:.......:.:.|:   :|::.|:               .|:|     .::||:::|:|||.|
Human   220 ECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIK-----QEVPIIIVFRALGFV 279

  Fly   254 SDQEIQSLIGI---DSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEEA 315
            ||::|...|..   |.:.......||.:|:.::  .|..||.::||:   ......|.:...:.|
Human   280 SDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGSR---GAKPGVTKEKRIKYA 339

  Fly   316 RELLLTTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMF 380
            :|:|...:|.||.|.:|....||.::..||.|::.|.|.:...||||:||||||:|||.||:.:|
Human   340 KEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLF 404

  Fly   381 EDLFKRMNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNW-TIKRFKMERAGVT 444
            ..:||.:..|::..|.|.|.:.|  .|::...::...|:.||:.::::||| ..|:....||||:
Human   405 RGMFKNLLKEVRIYAQKFIDRGK--DFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVS 467

  Fly   445 QVLSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHI 509
            |||:||::.|.|..:.|:||...:..|::.||.|..:.|||:||::||||.|.|||||||||.:|
Human   468 QVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYI 532

  Fly   510 TTEVEERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRK-G 573
            :...:..|::.......:|::.|:|  |....:...:|:||..:|:..:.:.|:..||.:||: .
Human   533 SVGSQPSPILEFLEEWSMENLEEIS--PAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMD 595

  Fly   574 RMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFD-----DFLL 633
            .:.|.||:.....:|.|.|:||.||:|||.:|||.::.|:|:.|:|:|..  |:::     |.:.
Human   596 IIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKE--REYNNYSWQDLVA 658

  Fly   634 DGLIEYLDVNEENDSFIAWNEDQIEDRT-------THLEIEPFTLLGVCAGLVPYPHHNQSPRNT 691
            .|::||:|..||....:|...|.::::.       ||.||.|..:|||||.::|:|.||||||||
Human   659 SGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNT 723

  Fly   692 YQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGY 756
            ||.||||||||:...|...|:|:|.:.|.||..|:|.::::|...|.:||||.|:.||:.||:||
Human   724 YQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGY 788

  Fly   757 DIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDR---IMGPMKDALTNKVIFKHDVLDT 818
            :.||::|:|::::|||:.|.:.|::.|   ::.:.:.||:   ...|.::.........:|.||.
Human   789 NQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDD 850

  Fly   819 DGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPIS--YKGPEPSYIERVMVSANA 881
            ||::|||.:|....::|.|.:....:.:.|:..:.:  ||....|  .:..|...:::|||:.|.
Human   851 DGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRR--YTKRDCSTFLRTSETGIVDQVMVTLNQ 913

  Fly   882 EEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTV 946
            |.....||.:|..|||:|||||:|||||||..|:...||||||...||.||:|:|||..|||||:
Human   914 EGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTI 978

  Fly   947 GKTLELLGGKAGLLEGKFHYGTAFGGS-KVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYS 1010
            |..:|.|.||....:|:....|.|..: .|:.|...|..:|::..|.:..|:|.||..:.:.|:.
Human   979 GHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFI 1043

  Fly  1011 GPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLM 1075
            ||.|||:|||||.||:|:|||||..:|.|||.:||||:||||.|||||||.|::||:..:.|||.
Human  1044 GPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLF 1108

  Fly  1076 ISSDAFEVDVCRTCGRMAYCSW------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMI 1133
            .:||.::|.||..||.||..:.      |..|::...:|.:.||||||||||||.||::.|:|:
Human  1109 EASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMM 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	436/1169 (37%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	432/1155 (37%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	50/180 (28%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	23/61 (38%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	13/51 (25%)
POLR2B	NP_000929.1	PRK08565	27..1172	CDD:236291	435/1167 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820