DRSC/TRiP Functional Genomics Resources

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Protein Alignment Polr3B and POLR2B

DIOPT Version :10

Sequence 1:NP_523706.1 Gene:Polr3B / 36289 FlyBaseID:FBgn0004463 Length:1137 Species:Drosophila melanogaster
Sequence 2:NP_000929.1 Gene:POLR2B / 5431 HGNCID:9188 Length:1174 Species:Homo sapiens


Alignment Length:494 Identity:99/494 - (20%)
Similarity:155/494 - (31%) Gaps:170/494 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 NISQEGIFRKTGSLARQNELKSLLLQGNVLPLDEAGYTAHDCASVLKSFLADLPE---------P 161
            |:.:..|..:.||:.......::..|||   ||...|..|:..|........|.|         |
Human   221 NLQKPTIKAEPGSVITSKRAMTIWCQGN---LDAEVYFLHNEKSQKTQSTQTLQEPGNKGRFFIP 282

  Fly   162 LLTELY---YPAYCQVADLYHSKEAAQPARNEDRLLNAL----QLLLLLLPEE-----NNILLRH 214
            .:|:.:   |..||     |.|...:||:...:.::..:    :..|.:||..     .|:.| |
Human   283 SVTQQHAGQYRCYC-----YSSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTL-H 341

  Fly   215 IIELLH--RTIQHEATNKMSAVNLATLFTPHLICPRKQSPEALH----TTAQHMSGI--VGFMIK 271
            .....|  :.|..:...|.:    ::|.|.|:...|:.  .||.    ||..|....  .|: .|
Human   342 CASDFHYDKFILTKEDKKFT----SSLDTEHISSSRQY--RALFIIGPTTPTHTGTFRCYGY-YK 399

  Fly   272 TGPRLFHIP--------------PKLATDIRAYFVDQRRRKTMS--------------------P 302
            ..|:|:.:|              |.|.|. :.:.:|.....|:.                    .
Human   400 NAPQLWSVPSALQQILISGLSKKPSLLTH-QGHTLDPGMTLTLQCFSDINYDRYALHKVGRADIM 463

  Fly   303 EHILNESTTSDSVANTVYTFVDREKTAEALEMNSTDTALAQLYAHIQSLPESSKKKKLVSKFNRQ 367
            :|...::.|..||||....:|.          :||........||..|...|:..:         
Human   464 QHSSQQTDTGFSVANFTLGYVS----------SSTGGQYRCYGAHNLSSEWSASSE--------- 509

  Fly   368 NGYGTPLQVLLREKNGSGTGSAGLASGGGLKYPRSISDSIKRHIFHKSLMSRTPKRGTISGSQTP 432
                 ||.:|:       ||...|                                       ||
Human   510 -----PLDILI-------TGQLPL---------------------------------------TP 523

  Fly   433 TTFQTPNGTGYGSGPRQRVLFQSPVSAS----DSPSSVGSPLCIKRCS--SVSSSSSSLSSMSSS 491
            :....||.|.: ||....:|..|..|..    ....|...||.:|..|  ..|.:..|:|:::|.
Human   524 SLSVQPNHTVH-SGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSH 587

  Fly   492 -SGTGN------------AKAAGSLTRTISSESASSTSS 517
             |||..            :.|:..:..|:|....|||.|
Human   588 LSGTYRCYGAQDSSFYLLSSASAPVELTVSETIESSTWS 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Polr3BNP_523706.1 RNA_pol_B_RPB2 47..1133 CDD:238353 99/494 (20%)
RNA_pol_Rpb2_4 546..607 CDD:428012
RNA_pol_Rpb2_5 628..668 CDD:428013
POLR2BNP_000929.1 Ricin_B_lectin 27..1172 CDD:481363 99/494 (20%)
Blue background indicates that the domain is not in the aligned region.

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