DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and Polr3b

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_001178807.1	Gene:	Polr3b / 362858	RGDID:	1565311	Length:	1133	Species:	Rattus norvegicus

Alignment Length:	1120	Identity:	772/1120 - (68%)
Similarity:	932/1120 - (83%)	Gaps:	6/1120 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KDWSVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYL 86
            ::.:.||..:.|||:|:||||:|||||||||||||:||||:||||:||||.|||.|||::|||||
  Rat    14 EELAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYL 78

  Fly    87 DVRVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRIKRNNLLIGRMPLMLRCS 151
            ::.||.||:::.||:|:..:||||||||.|||||||||||||||:|||.||.|.|||||:|||.|
  Rat    79 NIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSS 143

  Fly   152 NCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLTE-DFNGVVQCQVTSSTH 215
            ||.||||:..|.:|||||||||||||:|:|.|||||||||||.|:::.| |..|.|...||||||
  Rat   144 NCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTH 208

  Fly   216 EKKSRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLIGIDSKSQNRFGASLIDAY 280
            ||||||.:..|.|::||:||::::|||||:||||:||.|||||..:||.:......||.||.:..
  Rat   209 EKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQ 273

  Fly   281 NLKVFTQQRALEYMGSKLVVKR-FQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMM 344
            ..::|||.:||:|:|:|:..:| :.....||..|||||||.:|||.||||..||.:.|.||.::|
  Rat   274 KAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVM 338

  Fly   345 VRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDV 409
            ||||:.|:.|..: |||||||||||||||.|||::||||||:.|.|:|.|||:.|||.:||||||
  Rat   339 VRRVILAQGDNKV-DDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDV 402

  Fly   410 VKHMRAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVNSQFEKTRKVSG 474
            |||||..|||.|:.:|||:|||::|||||:|.||||||||||||||||||||::|||||||||||
  Rat   403 VKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSG 467

  Fly   475 PRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEERPVMIVAFNAGVEDIREVSGNPIN 539
            |||||||||||||||||||||||||||||||||||||::|:.|::.:|.|.||||:..:.|..::
  Rat   468 PRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIIKLAGNLGVEDVNLLCGEELS 532

  Fly   540 NPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYV 604
            .|||||||:|||:||:..:||.||...|.|||.|.:..:||:.|:.|.||:||.:|||||||||:
  Rat   533 YPNVFLVFLNGNILGVIRDHKKLVSTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYI 597

  Fly   605 IVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTHLEIEPF 669
            ||:.::|.|...|::||.:|.|.|:|||.:.|:||||||||||..||..|..|...|||||||||
  Rat   598 IVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPF 662

  Fly   670 TLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIEL 734
            |||||||||:|||||||||||||||||||||||.|||||:||||:|||.|.||..||||:|||||
  Rat   663 TLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIEL 727

  Fly   735 TNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMG 799
            .:|:||||||||||||||||||||||||:|||||:|||:||||||||:|||:|||.|||||::||
  Rat   728 IDFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMG 792

  Fly   800 PMKDALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSA--QVPYTAVPI 862
            ||.||.|.|.|::|::||.|||.:|||:|:|||:::||.||.||.: ||:|.:.  |..|..|||
  Rat   793 PMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQI-PLEGSNVPQQPQYKDVPI 856

  Fly   863 SYKGPEPSYIERVMVSANAEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDF 927
            :|||...||||:||:|:|||:.||||:||||||.||||||||||||||||.||||.||||||.|.
  Rat   857 TYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDS 921

  Fly   928 GICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAFGGSKVEDIQAELERHGFNYVGK 992
            |||||:|||||||||||||||.:|||.||||:|:|:||||||||||||:|:..:|.|||:||:||
  Rat   922 GICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGK 986

  Fly   993 DFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEME 1057
            |:..|||||.|||||||.||||||||||||.||||||||||:||||||||:||||:|||||||||
  Rat   987 DYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEME 1051

  Fly  1058 RDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCSWCHFCQSSANVSKISMPYACKLLFQE 1122
            |||||.||||||::|||||||||||||||..||.:.|..|||:|:||.:||.:.:||||||||||
  Rat  1052 RDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQE 1116

  Fly  1123 LTSMNVVPKMILENY 1137
            |.|||::|::.|..|
  Rat  1117 LQSMNIIPRLKLAKY 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	767/1104 (69%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	757/1089 (70%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	87/160 (54%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	34/60 (57%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	25/39 (64%)
Polr3b	NP_001178807.1	PRK08565	26..1129	CDD:236291	767/1104 (69%)
		RNA_pol_B_RPB2	39..1127	CDD:238353	757/1089 (70%)
		RNA_pol_Rpb2_4	539..600	CDD:282431	34/60 (57%)
		RNA_pol_Rpb2_5	621..661	CDD:282432	25/39 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340758
Domainoid	1	1.000	603	1.000	Domainoid score	I186
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6981
Inparanoid	1	1.050	1589	1.000	Inparanoid score	I78
OMA	1	1.010	-	-		QHG54037
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	1	1.000	-	-		oto97778
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	1	1.100	-	-	LDO	PTHR20856
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770