Protein Alignment Polr3B and rpb-2

DIOPT Version :10

• Sequence 1: NP_523706.1
• Gene: Polr3B / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: NP_498047.2
• Gene: rpb-2 / 175668
• WormBaseID: WBGene00016140
• Length: 1194
• Species: Caenorhabditis elegans
• Alignment Length: 1162
• Identity: 430/1162 - (37%)
• Similarity: 670/1162 - (57%)
• Gaps: 76/1162 - (6%)

  Fly    35 WKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKAN----------ELVTSGADPL-FYLKYLDV 88
            |.::.|:...||||:|.:|||:.|:.:::::||:.:          .|.|...:|. |.||:..:
 Worm    35 WVVISAYFDEKGLVRQQLDSFDEFVQMNVQRIVEDSPPVELQSENQHLGTDMENPAKFSLKFNQI 99

  Fly    89 RVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIE--YTR---GTQRIKRNNLLIGRMPLML 148
            .:.||...:.........|:|.|||:.||::|:.|||.  .||   .|::: .:.:.:|::|:||
 Worm   100 YLSKPTHWEKDGAPMPMMPNEARLRNLTYASPLYVDITKVVTRDDSATEKV-YDKVFVGKVPVML 163

  Fly   149 RCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWN-----KMLTEDFNGVVQC 208
            |.|.|.|:..::.:|::|||||||||||||:.|.|||::.||:::.|     .|....:....:|
 Worm   164 RSSYCMLSNMTDRDLTELNECPLDPGGYFVINGSEKVLIAQEKMATNTVYVFSMKDGKYAFKTEC 228

  Fly   209 QVTSSTHEKKSRTL---VLSKHG---------------KYYLKHNSMTDDIPIVVIFKALGVVSD 255
            :.......:.:.|:   :|::.|               ..|:|     .:|||:::|:|||.|||
 Worm   229 RSCLENSSRPTSTMWVNMLARGGGGGKKTAMGQRIIGILPYIK-----QEIPIMIVFRALGFVSD 288

  Fly   256 QEIQSLIGI---DSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEEARE 317
            ::|...|..   |.:.......||.:|:.::  .|..||.::|::   ......|.:...:.|||
 Worm   289 RDILGHIIYDFNDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGAR---GAKPGVTREQRIKYARE 348

  Fly   318 LLLTTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFED 382
            :|...:|.||.|.......||.::..||.|::.|.|.:...||||:.|||||:|||.||:.:|..
 Worm   349 ILQKELLPHVGVSEHCETKKAFFIGYMVHRLLLAALGRRELDDRDHIGNKRLDLAGPLLAFLFRS 413

  Fly   383 LFKRMNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNW-TIKRFKMERAGVTQV 446
            ||:.:..|::..|.|.|.|......||.  ::.:.||.||..::::||| ..|:....||||:||
 Worm   414 LFRNLLKEMRMTAQKYINKNDDFALDVC--VKTSTITRGLTYSLATGNWGDQKKAHQSRAGVSQV 476

  Fly   447 LSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITT 511
            |:||:|.:.|..:.|.||...:..|::.||.|..:||||:||::||||:|.|||||||||.:|:.
 Worm   477 LNRLTYTATLSHLRRANSPIGREGKLAKPRQLHNTQWGMVCPAETPEGQAVGLVKNLALMAYISV 541

  Fly   512 EVEERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRK-GRM 575
            .....|::.......:|::.|||.:.|  .:...:|:||..:|:......|:..|:.:||: ..:
 Worm   542 GSLPEPILEFLEEWSMENLEEVSPSAI--ADATKIFVNGAWVGIHREPDQLMTTLKKLRRQMDII 604

  Fly   576 GSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRK-----FDDFLLDG 635
            .|.||:......|.|.|:||.||:|||.:||||::..:|:.|:|:|.....:     :.|.:..|
 Worm   605 VSEVSMVRDIRDREIRIYTDAGRVCRPLLIVENQKLALKKRHIDQLKEAADEANKYTWSDLVGGG 669

  Fly   636 LIEYLDVNEENDSFIAWNEDQIE-----DRTTHLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCA 695
            ::|.:|..||..|.||...:.:.     |..||.||.|..:|||||.::|:|.||||||||||.|
 Worm   670 VVELIDSMEEETSMIAMMPEDLRSGGYCDTHTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSA 734

  Fly   696 MGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIED 760
            |||||||:...|...|:|:|.:.|.||..|:|.::::|...|::||||.||.||::|||||:.||
 Worm   735 MGKQAMGVYTTNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFNELPAGINAIVAILSYSGYNQED 799

  Fly   761 ALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALTNKVIFKHDVLDTDGIVAPG 825
            ::|:|.::||||..|.:.|::.:.......|...:.|..|.::..:......:|.||.|||::||
 Worm   800 SVIMNNSAIDRGLFRSVFYRSYRDNEANLDNANEELIEKPTREKCSGMRHSLYDKLDEDGIISPG 864

  Fly   826 EQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDFLIKIL 890
            .:|....::|.|.:......:.|.....:.|........:..|...:::||:|.|::.:..:||.
 Worm   865 MRVSGDDVIIGKTVALPDIDDDLDASGKKYPKRDASTFLRSSETGIVDQVMLSLNSDGNKFVKIR 929

  Fly   891 LRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGG 955
            :|..|:|:|||||:|||||||..|::..||||||...|:.||:|:|||..|||||:|..:|.|.|
 Worm   930 MRSVRLPQIGDKFASRHGQKGTMGIMYRQEDMPFTAEGLTPDIIINPHAVPSRMTIGHLIECLQG 994

  Fly   956 KAGLLEGKFHYGTAFGGS-KVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLK 1019
            |....:|:....|.|..: .|:.|...|..:|::..|.:..|:|.||..|...|:.||.|||:||
 Worm   995 KLSANKGEIGDATPFNDTVNVQKISGLLCEYGYHLRGNEVMYNGHTGKKLTTQIFFGPTYYQRLK 1059

  Fly  1020 HMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVD 1084
            |||.||:|:|||||..::.|||.:||:|:||||.|||||||.||:||:..:.|||...||.:.|.
 Worm  1060 HMVDDKIHSRARGPIQMMNRQPMEGRARDGGLRFGEMERDCQISHGATQFLRERLFEVSDPYHVY 1124

  Fly  1085 VCRTCGRMAYCSW------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMILE 1135
            ||..||.:...:.      |..|::...||.:.:|||||||||||.||::.|:::::
 Worm  1125 VCNNCGLIVVANLRTNSFECKACRNKTQVSAVRIPYACKLLFQELMSMSIAPRLMVK 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3B	NP_523706.1	RNA_pol_B_RPB2	47..1133	CDD:238353	426/1146 (37%)
		RNA_pol_Rpb2_4	546..607	CDD:428012	22/61 (36%)
		RNA_pol_Rpb2_5	628..668	CDD:428013	14/44 (32%)
rpb-2	NP_498047.2	Ricin_B_lectin	35..1183	CDD:481363	430/1162 (37%)