Protein Alignment Polr3B and polr1b

DIOPT Version :10

• Sequence 1: NP_523706.1
• Gene: Polr3B / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: XP_002940442.1
• Gene: polr1b / 100485503
• XenbaseID: XB-GENE-1008539
• Length: 1135
• Species: Xenopus tropicalis
• Alignment Length: 1216
• Identity: 349/1216 - (28%)
• Similarity: 545/1216 - (44%)
• Gaps: 211/1216 - (17%)

  Fly    18 PGDSKDWSVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFY 82
            ||:|:  ..|::.:|                :.||||||..:...:...|:|.:       ||.:
 Frog    27 PGESQ--HPPLQDIT----------------RAHIDSFNQAMTEGLSLAVQAMK-------PLEF 66

  Fly    83 --------LKYLDVRVGKPDIDDGFNITKATT--PHECRLRDTTYSAPITVDIEYT-RGTQR--I 134
                    |:.:|..:..|.:..| :|.|...  |.|||.|.:||...:|.|:.:: .|.|:  |
 Frog    67 TYKNDKVALQIVDAVITPPLVPKG-SICKEQKIYPAECRGRRSTYRGKLTADVSWSLNGLQKGII 130

  Fly   135 KRNNLLIGRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVI--LIQEQLSWN-K 196
            |:.   :|.:|:|::...|.|...:..:|.:.:|...:.||||::.|.||||  ||..:.::. .
 Frog   131 KQT---LGHIPIMVKSKFCNLYDLNPKQLLEHHEEEQEMGGYFIINGIEKVIRMLIMPRRNFPIA 192

  Fly   197 MLTEDFN----GVVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTDD---------IPIVVIFK 248
            |:...:.    |..|..::......:...:.::.|   ||::.|:..:         ||:....|
 Frog   193 MIRPKWKNRGPGYTQYGISLRCVRDEHTAVNMNLH---YLENGSVMVNFIYQKELFFIPLGFALK 254

  Fly   249 ALGVVSDQEIQSLIGIDSKSQNRFGASLIDAYNLKV-----FTQQRALEYMGSKLVVKRFQSATT 308
            ||...||.:|.:.: |..|.:|.|....:......|     .:|:..|:|:|.:..|| |.....
 Frog   255 ALVDYSDYQIFTEL-IKGKEENSFYRDCMTQMLRAVVEEGCHSQKNVLKYLGERFRVK-FYLPDW 317

  Fly   309 KTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAG 373
            .|..:.|..|:...|..|:..   |:: |...:.||.:::.....|..:.::.|....:.:...|
 Frog   318 FTDEQAAEFLISQCICIHLKT---NVE-KFYMLCMMTQKLFTFAKDGCMEENPDSLMYQEVMTPG 378

  Fly   374 SLLSMMFEDLFKRMNWEL--KTIADK------------NIPKVKAAQFDVVKHMRAAQITAGLES 424
            .||.|..::  |..:|.|  |...||            .:.||..:..|:.|.......|..|.|
 Frog   379 QLLLMFLKE--KMESWLLGVKVNLDKRAHKYTVDLSTETMMKVFTSTSDLTKTCEYLLATGNLRS 441

  Fly   425 AISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVN--SQFEKTRKVSGPRSLQPSQWGMLC 487
            ....|       .::.:|:..|..:|::|..|.....|:  :.|.|.|..| .|.|.|..||.||
 Frog   442 KTGLG-------MLQSSGLVVVADKLNFIRYLSHFRCVHRGAAFAKMRTTS-VRRLLPESWGFLC 498

  Fly   488 PSDTPEGEACGLVKNLALMTHITTEVEERPVM-IVAFNAGVEDIREVSGNPINNPNVFLVFINGN 551
            |..||:||.|||:.::.....|.|:.....:: ::..:.|:..:...:|...  .:.:.|.::|.
 Frog   499 PVHTPDGEPCGLMNHMTAACEIVTQTSYNTLLPLLLCSLGMTPVDGTAGKLF--ADCYPVMLDGA 561

  Fly   552 VLG-----LTLNHKHLVRNLRYMRRK--------------GRMGSYVSVHTSYTQRCIYIHTDGG 597
            ::|     :.......:||.:....|              |:...|..         :::.|...
 Frog   562 MVGWVEKTIAPGLVSALRNYKVKHEKNVPPWTEIVLIPMTGKASLYPG---------LFLFTTPC 617

  Fly   598 RLCRPYVIVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTT 662
            |:.||   |.| ..|.|:..|                |.:|.:.:|     ...:..|.:...||
 Frog   618 RMVRP---VRN-LALGKEELL----------------GTLEQVFLN-----VAVYEGDIVPGETT 657

  Fly   663 HLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMV 727
            |.|..|.::|.|.|..:|:..|||||||.|||.||||.||......::|.|:.:|.|..|.:|:|
 Frog   658 HQEFFPHSMLSVVANFIPFSDHNQSPRNMYQCQMGKQTMGFPLMTYQDRSDNKLYRLQTPQSPLV 722

  Fly   728 KSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQ 792
            :....:....|..|.|.||.|||:||:|||:|||::|||:|.:||:....|||.....:.:
 Frog   723 RPSMYDYYEMDNYPIGTNAIVAVISYTGYDMEDAMVLNKSSWERGFAHGSVYKTDHVDLSK---- 783

  Fly   793 TFDRIMGPMKDALTNKVI-FKHD------VLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQG 850
                   .:||...|.|. .|.|      .||:||:.|.|..:|...       |....:|...|
 Frog   784 -------KLKDGEDNLVFGIKPDDERVKGRLDSDGLPAVGAVLQFGD-------PYYGYLNLNTG 834

  Fly   851 QSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDF----LIKILLRQTRIPEIGDKFSSRHGQKG 911
            :|. |.|      ||..|...|:.:.:.:| :..|    .:.:.:|..|.|.|||||:|||||||
 Frog   835 ESF-VAY------YKSKENCVIDNIKICSN-DIGFGKFKSVCVTMRIPRNPTIGDKFASRHGQKG 891

  Fly   912 VTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAF----GG 972
            :...:...|||||.:.|:.||::.||||||||||:|..:|.:.||:..|.|..|..|.|    ..
 Frog   892 ILSRLWPSEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFTFSEEN 956

  Fly   973 SKVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVL 1037
            |.:|.....|...|:|:.|.:..||||:|..|||.|:.|.||||:|:|||.||...|..|.:..:
 Frog   957 SALEYFGEMLRAGGYNFYGTEKLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKV 1021

  Fly  1038 TRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAY-------C 1095
            |.||..||:.:||:|.||||||.|:::|.|.|:.:||...||.....||..||.:..       .
 Frog  1022 TNQPVGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSTAHVCIECGSLLSPFLEKPPP 1086

  Fly  1096 SW---------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKM 1132
            ||         |..|..:..|..:|:||..:....||.:||:..|:
 Frog  1087 SWSSIRNRKHHCEVCDRTDTVETVSVPYVFRYFVAELAAMNISVKL 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3B	NP_523706.1	RNA_pol_B_RPB2	47..1133	CDD:238353	344/1187 (29%)
		RNA_pol_Rpb2_4	546..607	CDD:428012	12/79 (15%)
		RNA_pol_Rpb2_5	628..668	CDD:428013	8/39 (21%)
polr1b	XP_002940442.1	RNA_pol_B_RPB2	38..1132	CDD:238353	344/1201 (29%)
		RNA_pol_Rpb2_2	186..374	CDD:398318	38/196 (19%)
		RNA_pol_Rpa2_4	563..621	CDD:462028	8/66 (12%)