Protein Alignment otk and ROR2

DIOPT Version :10

• Sequence 1: NP_523705.2
• Gene: otk / 36283
• FlyBaseID: FBgn0004839
• Length: 1033
• Species: Drosophila melanogaster
• Sequence 2: NP_004551.2
• Gene: ROR2 / 4920
• HGNCID: 10257
• Length: 943
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 177/781 - (22%)
• Similarity: 295/781 - (37%)
• Gaps: 199/781 - (25%)

  Fly   363 PINSSPGILEVIEQ--LKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVR-DGENTTLPDHV 424
            |::...|.:..::.  |.|: :|.:....:....|.:|||..|.|.|.|:|:: |......|..:
Human    46 PLDGQDGPIPTLKGYFLNFL-EPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRI 109

  Fly   425 ---EVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTV 486
               :.:....|..:::::...|.|.|:|||....|.||..:.|.:.|..|
Human   110 IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHS--------------- 159

  Fly   487 VMHCQAIGDPKPTIQWDKDLKYLSENNTDRER----FRFLENGTLEIRNVQVEDEGSYGCT---- 543
                     |....|.|    |..:......|    .||:.|.|:.:.::|::.|.....|
Human   160 ---------PNHNFQDD----YHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFT 211

  Fly   544 -IGNSAGLKREDVQLVVKTTGDGFA---------------PEESGGDGFLVTRAVLITM--TVAL 590
             ||.|..|..:..|..:.:    |.               |.|...|...|..:.|...  |:|.
Human   212 MIGTSTHLSDQCSQFAIPS----FCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIAR 272

  Fly   591 AYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAG------------------NGKGSE 637
            :..::::.|.|          .:...|...|:    ||.|.                  ||.|.:
Human   273 SNPLILMRLQL----------PKCEALPMPES----PDAANCMRIGIPAERLGRYHQCYNGSGMD 323

  Fly   638 QEPCLSKQHNGHS---------KSRSKSSGD-------------------------------AQK 662
            .....|...:||.         .|...||.|                               .:.
Human   324 YRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMEL 388

  Fly   663 SDDTACSQQSRASKKSAHIY---EQLALPR--SGLSELIQIGRGEFGDVFVGKLKAT-------- 714
            .|..:||  .|.|.|...:|   ..:|:|.  :.|..|:.:.|        .|.||:
Human   389 CDVPSCS--PRDSSKMGILYILVPSIAIPLVIACLFFLVCMCR--------NKQKASASTPQRRQ 443

  Fly   715 LVTSPS-DKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSG 778
            |:.||| |.:.....||..::                 .|..|.:::..:||:.|:...:..:..
Human   444 LMASPSQDMEMPLINQHKQAK-----------------LKEISLSAVRFMEELGEDRFGKVYKGH 491

  Fly   779 L--------EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYT 835
            |        .|.|.:|.|....:....:|||.:..|...:.|..||.|.|:..:..|..|:..|.
Human   492 LFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYC 556

  Fly   836 DWGDLKQFLL-----ATAGKV-NTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLA 894
            ..|||.:||:     :..|.. :..|..|:..||    ..:.:..|||.||:.:......|:|||
Human   557 SHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP----DFVHLVAQIAAGMEYLSSHHVVHKDLA 617

  Fly   895 TRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVV 958
            |||.::..:..||:|...|.::.|:.:|:| ..|:||||||:|||.|...:::..|||::||||:
Human   618 TRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVL 682

  Fly   959 WELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAA 1023
            ||:|:...: |:...:|:.||:..:...: ....:..|..:..:::.||...|..||.|..:.:.
Human   683 WEVFSYGLQ-PYCGYSNQDVVEMIRNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSR 745

  Fly  1024 L 1024
            |
Human   746 L 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	Ig_3	31..99	CDD:464046
		Ig strand B	133..137	CDD:409353
		Ig	<135..197	CDD:472250
		Ig strand C	150..154	CDD:409353
		Ig strand E	171..175	CDD:409353
		Ig strand F	185..190	CDD:409353
		Ig	265..360	CDD:472250
		Ig strand B	272..276	CDD:409571
		Ig strand C	290..294	CDD:409571
		Ig strand E	337..341	CDD:409571
		Ig strand F	351..356	CDD:409571
		Ig	395..460	CDD:409353	20/68 (29%)
		Ig strand B	395..399	CDD:409353	1/3 (33%)
		Ig strand C	408..412	CDD:409353	1/3 (33%)
		Ig strand E	430..434	CDD:409353	1/3 (33%)
		Ig strand F	444..449	CDD:409353	2/4 (50%)
		Ig strand G	457..460	CDD:409353	1/2 (50%)
		I-set	468..559	CDD:400151	19/99 (19%)
		Ig strand B	486..490	CDD:409570	0/3 (0%)
		Ig strand C	499..503	CDD:409570	1/3 (33%)
		Ig strand E	525..529	CDD:409570	1/3 (33%)
		Ig strand F	539..544	CDD:409570	1/9 (11%)
		Ig strand G	552..555	CDD:409570	0/2 (0%)
		PTK_CCK4	686..1026	CDD:133178	99/365 (27%)
ROR2	NP_004551.2	I-set	64..152	CDD:400151	23/88 (26%)
		Ig strand B	79..83	CDD:409353	1/3 (33%)
		Ig strand C	92..96	CDD:409353	1/3 (33%)
		Ig strand E	118..122	CDD:409353	1/3 (33%)
		Ig strand F	132..137	CDD:409353	2/4 (50%)
		Ig strand G	145..148	CDD:409353	1/2 (50%)
		CRD_TK_ROR2	170..309	CDD:143577	28/156 (18%)
		KR	314..395	CDD:214527	11/80 (14%)
		PTKc_Ror2	466..749	CDD:270673	84/287 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	757..796
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	850..931