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Protein Alignment otk and NTRK1

DIOPT Version :10

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_002520.2	Gene:	NTRK1 / 4914	HGNCID:	8031	Length:	796	Species:	Homo sapiens

Alignment Length:	974	Identity:	233/974 - (23%)
Similarity:	347/974 - (35%)	Gaps:	297/974 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 WYRNSEKLSTWKNVQLDQHRLIIRQPGSE----------DDGLYRCT-------------ASNAA 194
            |......|..|         ||:...|:.          ..|| |||             |.|..
Human    15 WAAGPGSLLAW---------LILASAGAAPCPDACCPHGSSGL-RCTRDGALDSLHHLPGAENLT 69

  Fly   195 GRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESW------DKQTFLCRGKRGGAA--GLEALPAAP 251
            ...:..|.::....::.|..|...:|..:::|.      |...|..|..|...:  .||:|
Human    70 ELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESL---- 130

  Fly   252 EDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSF 316
             ..:.|||...|.::..|.|...:|..         |...||.::|       |||   :|
Human   131 -SWKTVQGLSLQELVLSGNPLHCSCAL---------RWLQRWEEEG-------LGG---VP---- 171

  Fly   317 DSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVP 381
                      :.:|..|.| |.|                    ||.| |:|.|:
Human   172 ----------EQKLQCHGQ-GPL--------------------AHMP-NASCGV----------- 193

  Fly   382 QPTSK----NLELDA---VVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANG-----TLIF 434
             ||.|    |..:|.   |:  :.|:.:|....|..|:.    |.|.....|..:|     .|..
Human   194 -PTLKVQVPNASVDVGDDVL--LRCQVEGRGLEQAGWIL----TELEQSATVMKSGGLPSLGLTL 251

  Fly   435 RNVNSE-HRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAI----- 493
            .||.|: :|.|.||.|.|..|:...:|.:||      |.|....:.|:    |.||...|
Human   252 ANVTSDLNRKNVTCWAENDVGRAEVSVQVNV------SFPASVQLHTA----VEMHHWCIPFSVD 306

  Fly   494 GDPKPTIQWDKDLKYLSENNTDRERFRFLE-----------NGTLEIRNVQVEDEGSYGCTIGNS 547
            |.|.|:::|..:...|:|.:     |.|.|           :|.|.:......:.|:|.....|.
Human   307 GQPAPSLRWLFNGSVLNETS-----FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 366

  Fly   548 AGLKREDVQLVVKTTGDGFAPEE-------------SGGD----------GFLVTRAVLITMTVA 589
            .|.....:..........|.||:             :.||          |..|...:.:...:.
Human   367 FGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLF 431

  Fly   590 LAYIVLVVGLMLWCRYRRQARKARLNDLSTKE-----------AGGDQPDVAGNGKGSEQEPCLS 643
            |:.::||:..   |..|.:....|...|:.::           .|.......|.|.|.:
Human   432 LSTLLLVLNK---CGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ------ 487

  Fly   644 KQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFV 708
                ||.....:...|       ||..         ||      .|..:....::|.|.||.||:
Human   488 ----GHIIENPQYFSD-------ACVH---------HI------KRRDIVLKWELGEGAFGKVFL 526

  Fly   709 GKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQ 773
            .:....|                                                     .|||
Human   527 AECHNLL-----------------------------------------------------PEQD- 537

  Fly   774 HNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWG 838
                  :.||.|||| |...|.|.|:|:|:.:||..:.|:.:||.||:|.|..|..||.||...|
Human   538 ------KMLVAVKAL-KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 595

  Fly   839 DLKQFLLATAGKVNTATAGSS-SPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISS 902
            ||.:||.:..........|.. :|.||...|:||||.|:|.||..:....|.|||||||||::..
Human   596 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660

  Fly   903 EFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQAT 966
            ..:||:....:.:|.||.:|:: ...|:|||||:.||.|...::||:||::::|||:||:|...
Human   661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG- 724

  Fly   967 KLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQS 1030
            |.|..:|:|.:.:.....|. |.....|.|..:..|:..||...|::|.|...:.|.|....|:
Human   725 KQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 787

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.