DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13192 and gnb1l

DIOPT Version :9

Sequence 1:	NP_610702.1	Gene:	CG13192 / 36259	FlyBaseID:	FBgn0033653	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001013526.1	Gene:	gnb1l / 541381	ZFINID:	ZDB-GENE-050320-77	Length:	323	Species:	Danio rerio

Alignment Length:	338	Identity:	110/338 - (32%)
Similarity:	175/338 - (51%)	Gaps:	32/338 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVLPPDPVFSLRSPDMGAVNSL---CFQESDRLL-AGTIKGSVFLWDLQTNRS--ALHFEVGSD 59
            ||..||||::.||... .:||:|   |..:...|| :|:.||:|.:|:|.|.|:  .|....|:.
Zfish     1 MARPPPDPLYILRGSG-ASVNALHFCCDGDGPPLLYSGSGKGAVHVWNLSTRRAERVLESHAGNS 64

  Fly    60 PI--TSLHHTPDRLVTQEKGGTITMFSIG-GSSYVKERSIPGNHLGFCRSALHTNTSKTNEQLLF 121
            .|  .:.:::...|::|.:...:.::.:. |.|.|.: |:....:|||:.:|  ..|:....||.
Zfish    65 VIWLNTFNNSRSCLISQGRDMRVCVWDLSEGRSAVTD-SLHTGSVGFCQCSL--LGSRLGSTLLA 126

  Fly   122 YP---CEESSIGVLHVTDAAAPTQI--LVPDDPQLPKLGSVTCFKPFECASQLFLLAGYESGHFL 181
            :|   .||.|     |.:.::.||:  |.||.    .||.:...|.::..|...|.||||.|..:
Zfish   127 HPTQHMEEVS-----VVEMSSWTQVCSLKPDS----NLGMLMSMKMWQADSGPVLCAGYEDGSVV 182

  Fly   182 TWDISSSVILDVMEL-AQDATSVDYDPVTNRGIVGGPTDKLISFSYQRSSMQMQLGSELCIKNPG 245
            .||:|......:::: .:...|:|.|....:||.|...:.|.|:... :...:|:...:.:.|||
Zfish   183 LWDVSHRRPFSLLKVHPEPVMSLDVDVCRQKGISGSSENILQSWRLD-NQQSLQMHDSIQMTNPG 246

  Fly   246 VNGVRIRPDQKVFASAGWDGRIRIFSWKSLRPLAVLTQHKNGGVMDLAFSSQQVAMWHAPIMAAA 310
            |:.:|||.|.|:.||||||..||:|.||.|:||||| ||....|..:|||..|.....  ::||.
Zfish   247 VSQLRIRADGKILASAGWDNNIRVFGWKKLKPLAVL-QHHTDMVNSVAFSDHQDPTQR--LLAAG 308

  Fly   311 GMDGQISLWDLYN 323
            ..|.:||:|.:|:
Zfish   309 SKDQRISVWSIYS 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13192	NP_610702.1	WD40	<5..321	CDD:225201	107/330 (32%)
		WD40 repeat	62..98	CDD:293791	6/36 (17%)
		WD40 repeat	103..147	CDD:293791	14/48 (29%)
		WD40 repeat	200..245	CDD:293791	10/44 (23%)
		WD40	201..>321	CDD:295369	48/119 (40%)
		WD40 repeat	247..282	CDD:293791	21/34 (62%)
gnb1l	NP_001013526.1	WD40	<8..322	CDD:225201	105/331 (32%)
		WD40	12..323	CDD:295369	104/327 (32%)
		WD40 repeat	20..58	CDD:293791	13/37 (35%)
		WD40 repeat	62..129	CDD:293791	15/69 (22%)
		WD40 repeat	136..199	CDD:293791	20/71 (28%)
		WD40 repeat	205..235	CDD:293791	7/30 (23%)
		WD40 repeat	247..283	CDD:293791	23/36 (64%)
		WD40 repeat	289..317	CDD:293791	10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12417
eggNOG	1	0.900	-	-		E2759_KOG0322
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41515
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4528
OMA	1	1.010	-	-		QHG55530
OrthoDB	1	1.010	-	-		D1543596at2759
OrthoFinder	1	1.000	-	-		FOG0006340
OrthoInspector	1	1.000	-	-		oto41771
orthoMCL	1	0.900	-	-		OOG6_103807
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R93
SonicParanoid	1	1.000	-	-		X4617
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870