DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and HXT8

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	222/515 - (43%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SVPADGLKANFTFSQ-----------------VLAALSV-SLCSLVVGFVSAY---TSPALVSMT 57
            |||.  ::.|..||:                 ..|.:|: .||....||:|.:   |....|:.|
Yeast    32 SVPT--VEENKDFSEYNGEEAEEVVVPEKPASAYATVSIMCLCMAFGGFMSGWDTGTISGFVNQT 94

  Fly    58 D--RTITSFEVTKDA-------GSWVGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSS 113
            |  |...::..:|:.       ...:..|..:.:..|.:....|.:..||...::...|.::|..
Yeast    95 DFLRRFGNYSHSKNTYYLSNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGI 159

  Fly   114 LL-IACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTL----GLLPTALGNIGILV 173
            :: ||..........||.:.|...|..|:..|:.:.||....:||||    .|:.|....:|...
Yeast   160 VIQIASIDKWYQYFIGRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMVTFAIFLGYCT 224

  Fly   174 CYVAGSFMN---WSMLAFLGAALPVPFLILMIIIPETPRWFVNRGQEERARKALKWLRGKEAD-- 233
            .|...::.|   |.:...|..|..:..:..|..:||:||:.|..|:.|:|:.:.........|
Yeast   225 NYGTKTYSNSVQWRVPLGLCFAWAIIMIGGMTFVPESPRFLVQVGKIEQAKASFAKSNKLSVDDP 289

  Fly   234 -VEPELKELMQSQADADRQATQNTCLELFKRNN--LKPLSISLGLMFFQQFSGINAVIFYTVQIF 295
             |..|: :|:.:..:|:......:..|||.|..  .:.|::::.:...||.:|.|...:|...||
Yeast   290 AVVAEI-DLLVAGVEAEEAMGTASWKELFSRKTKVFQRLTMTVMINSLQQLTGDNYFFYYGTTIF 353

  Fly   296 KDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFFYCKAH-- 358
            |..|.. ||..::|::|:|||.:.|..:..:|:|||:..|.:....|...:.|.......:.:
Yeast   354 KSVGMN-DSFETSIVLGIVNFASCFFSLYSVDKLGRRRCLLLGAATMTACMVIYASVGVTRLYPN 417

  Fly   359 ---GPDVSHLG--WLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFV 418
               .|.....|  .:..|||  ||..||..:||:.::::.|..|.::|....||.||.|....|:
Yeast   418 GKSEPSSKGAGNCTIVFTCF--YIFCFSCTWGPVCYVIISETFPLRVRSKCMSVATAANLLWGFL 480

  Fly   419 VTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIERKMM-GRVPMSS 477
            :......:|.|:..:..:...|.:.. ..|:|..|||||:|.:|||::...| |.:|..|
Yeast   481 IGFFTPFITSAINFYYGYVFMGCLAF-SYFYVFFFVPETKGLTLEEVDEMWMDGVLPWKS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	119/468 (25%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	109/453 (24%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	117/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.640