Protein Alignment inv and NKX2-4

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 64/260 - (24%)
• Similarity: 102/260 - (39%)
• Gaps: 49/260 - (18%)

  Fly   306 GSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGKPL-NLAQSNAAANSSLSFSSSLANICSNSNDSN 369
            |::.|:..|.....|.....|:|...|......: .:..|:|.|..:.:.:::.|
Human    29 GAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAA---------- 83

  Fly   370 STATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRS 434
              |.:::...|...|..:.:.|..|.|:...|..|..||       .||      |:|....|.:
Human    84 --AAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGE-------LPA------YTDGMRGGAA 133

  Fly   435 ---------PRARKPKK---PATSSSAAGGGG-GGVEKG-------EAADGGGVPEDKRPRTAFS 479
                     ||.....:   |:...:.||.|. .|:...       .||.....|..|| |..||
Human   134 TGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKR-RVLFS 197

  Fly   480 GTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQG 544
            ..|:..|:..|.:.:||:...|:.|:..:.|...|:||||||.|.|:|:.:  |:..|.||..:|
Human   198 QAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQA--KDKAAQQLQQEG 260

  Fly   545  544
            Human   261  260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	22/55 (40%)
		Engrail_1_C_sig	529..554	CDD:431338	5/16 (31%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	22/56 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		5/17 (29%)