Protein Alignment inv and NKX1-1

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 95/428 - (22%)
• Similarity: 145/428 - (33%)
• Gaps: 107/428 - (25%)

  Fly   111 AAQAALSAQAQARQRLLISQIYRPSAFSSTATTVLPPSEGPPFSPEDLLQLPPSTGTFQEEFLRK 175
            |||.|:..:|:.            .||.......|..|:..|.:||......|:.......|...
Human    33 AAQEAMDGRAEL------------PAFPRAGAPPLAASDTVPAAPEGAGAARPAAPLRPTSFSVL 85

  Fly   176 SQLYAEELMKQQMHLMAAARVNALTAAAAGKQLQMAMAAAAVATVPSGQDALAQLTATALGLGPG 240
            ..|...:...::...:....| |..|.|.......|.|.||....|..::...:..|.|.|:|..
Human    86 DILDPNKFNSRRRRCVLLGPV-APAACAPCASAPCAPAPAASGRPPRAEELERRALAGAGGVGAA 149

  Fly   241 GAVHPHQQLLLQRDQVHHHHHMQNHLNNNENLHERALKFSIDNILKADFGSRLPKIGALSGNIGG 305
            ||..|:.....:..:..         .|:.|                         |..||. ||
Human   150 GAEPPNAGDPFKAGEAE---------TNDTN-------------------------GYSSGG-GG 179

  Fly   306 GSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNS 370
            .|.|..|.....:..:.:.:.:|.....:..:..........|..|         .|..:.:::
Human   180 HSPSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGGGLGARGS---------GCQGAAETD- 234

  Fly   371 TATSSSTTNTSGAPVDLVKSP---PPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSG 432
             |:..:|.:.:.||.....||   .|..||.|.|.:|.:.:.:.|
Human   235 -ASPGATVDEAAAPGPRENSPVAQGPPGGAAAPGGAGTTPQGTAT-------------------- 278

  Fly   433 RSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLT 497
                |.|||:..|.|.:..|                 :.:|.||||:..||..|:::|...|||:
Human   279 ----AAKPKRKRTGSDSKSG-----------------KPRRARTAFTYEQLVALENKFKATRYLS 322

  Fly   498 EKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNP 535
            ...|..|:..|.|.|.|:||||||:|.|.||    :||
Human   323 VCERLNLALSLSLTETQVKIWFQNRRTKWKK----QNP 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	26/55 (47%)
		Engrail_1_C_sig	529..554	CDD:431338	2/7 (29%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		46/270 (17%)
		Homeodomain	297..353	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		5/11 (45%)