Protein Alignment inv and MEOX2

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_005915.2
• Gene: MEOX2 / 4223
• HGNCID: 7014
• Length: 304
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 74/339 - (21%)
• Similarity: 116/339 - (34%)
• Gaps: 126/339 - (37%)

  Fly   214 AAAVATVPSGQDALA------QLTATALGLGPGGAV---HPHQQLLL--QRDQVHHHHHMQNHLN 267
            |.|....|..|.:||      .::...|.......:   :|:::.:.  |..:.|||||..:|.:
Human    14 ATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHH 78

  Fly   268 NNENLHERALKFSIDNILKADFGSRLPKIGALSGNIGGGSVSGSSTGSSKNSGNTNGNRSPLKAP 332
            :::....:||:                                           ||.:     .|
Human    79 HHQQQQHQALQ-------------------------------------------TNWH-----LP 95

  Fly   333 KKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGA 397
            :.|..|       :||..||.....                       ||.|.:|..|||
Human    96 QMSSPP-------SAARHSLCLQPD-----------------------SGGPPELGSSPP----- 125

  Fly   398 GATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKP---KKPATSSSAAGGGGGGVEK 459
                                  |.|:..|...||..:..|..|   .:.|.|.:.|....||..|
Human   126 ----------------------VLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRK 168

  Fly   460 GEAADG--GGVPED-----KRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKI 517
            .:::|.  |....:     ::.||||:..|:..|:.||..:.|||..||.:::..|.|.|.|:|:
Human   169 SDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKV 233

  Fly   518 WFQNKRAKLKKSSG 531
            ||||:|.|.|:..|
Human   234 WFQNRRMKWKRVKG 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	24/55 (44%)
		Engrail_1_C_sig	529..554	CDD:431338	1/3 (33%)
MEOX2	NP_005915.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..192		40/233 (17%)
		COG5576	160..284	CDD:227863	31/88 (35%)
		Homeodomain	188..244	CDD:459649	24/55 (44%)