Protein Alignment inv and Zfhx3

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001414410.1
• Gene: Zfhx3 / 307829
• RGDID: 1560268
• Length: 3730
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 141/692 - (20%)
• Similarity: 219/692 - (31%)
• Gaps: 226/692 - (32%)

  Fly    20 EEAEDHAQERRAGGGGQEVGKMHPDC-LPLPLVQPGNSPQVRE------------EEEDEQTECE 71
            ||.:|.:|...:....:.:......| .|:| .|..::|....            .|.||.....
  Rat  2368 EEGQDDSQNEDSMDAMEILTPTSSSCSTPMP-SQAYSTPAPSSASTAPSAFLQLTAETDELATFN 2431

  Fly    72 EQLNIEDEEVEEEHDLDLEDPASCCSENSVLSVGQEQSEAAQAALSAQAQARQRLLISQIYRPSA 136
            .:....||:.::      .||.|.....:....||.:.|..|     |.||.|:..:.|...|..
  Rat  2432 SKAEASDEKPKQ------ADPPSVQPNQTQEKQGQPKPEVQQ-----QEQAEQKTNVPQPKLPQL 2485

  Fly   137 FSSTATTVLPPSEGPP-------------------------FSPEDLLQLPPSTGTFQ------- 169
              :..:...||.:.||                         .:|:.|..|||....:|
  Rat  2486 --AAPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLA 2548

  Fly   170 ----EEFLRKSQLYAEELMKQQMH-----------LMAAARVNALTAA--AAGKQLQM-AMAAAA 216
                |.:....||:......|.:|           .|.....|.|.|:  .:|...|: |.:|.:
  Rat  2549 FPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATS 2613

  Fly   217 VATVPSGQDAL-AQLTATALGLGPG-------GAVHP------------------HQQLLLQRDQ 255
            .:|..|..:.| .:|...|.|..||       |...|                  :|:.||..:.
  Rat  2614 PSTPTSTMNTLKRKLEEKASGASPGENDSSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNP 2678

  Fly   256 VHHHHHMQNHLNNNENLHERALKFSIDNILKADFGSRLPKIG-------------------ALSG 301
            .   ..|.:|:.:...|.:|.::....|....:...:...:|                   ||..
  Rat  2679 T---RKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEA 2740

  Fly   302 NI-------------------------GG----GSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGK 337
            :|                         ||    |.:...::.|......::|...||....|:
  Rat  2741 HIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSGSDGQGVPLSPVSKT-- 2803

  Fly   338 PLNLAQSNAAANSSLSF-------SSSLANICSN------SNDSNSTATSSSTTNTSGAPVDLVK 389
             :.|:.....:.||:..       |.|::::..|      .||..|:..::.|..|
  Rat  2804 -MELSPRTLLSPSSIKVEGLEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTT--------- 2858

  Fly   390 SPPPAAGAGATGASGKSGEDSGTPI-------------VWPAWVYCTRYSDRPSSGR-SPRARKP 440
                      ||..|.:..||.|.|             ...|.:..:.|.||.|||. ||.....
  Rat  2859 ----------TGDEGNADNDSATGIANETKSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFY 2913

  Fly   441 KK------------------PATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLK 487
            .|                  |.:.|..|.|..     |::.|.|..|..||.||..:..||..||
  Rat  2914 SKEYDNEGTVDYSETSSLADPCSPSPGASGSA-----GKSGDSGDRPGQKRFRTQMTNLQLKVLK 2973

  Fly   488 HEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKS 529
            ..||:.|..|....:.|..::||.:..:::||||.|||.|||
  Rat  2974 SCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKS 3015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	22/55 (40%)
		Engrail_1_C_sig	529..554	CDD:431338	1/1 (100%)
Zfhx3	NP_001414410.1	None