Protein Alignment inv and NKX2-8

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_055175.2
• Gene: NKX2-8 / 26257
• HGNCID: 16364
• Length: 239
• Species: Homo sapiens
• Alignment Length: 175
• Identity: 53/175 - (30%)
• Similarity: 73/175 - (41%)
• Gaps: 34/175 - (19%)

  Fly   418 AWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQ 482
            ||:...| ...|||..|.....|...:...||.          .|:.|....:.|:.|..||..|
Human    42 AWLDSER-GHYPSSDESSLETSPPDSSQRPSAR----------PASPGSDAEKRKKRRVLFSKAQ 95

  Fly   483 LARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKS---SGTKNP-LALQL--- 540
            ...|:..|.:.|||:...|:||:..|.|...|:||||||.|.|||::   ...::| ||...
Human    96 TLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELH 160

  Fly   541 MAQGLYNHSTIP-LTREEE--------ELQELQEAASAAAAKEPC 576
            .|.||.....:| |.|:.:        |:       ..|||:|.|
Human   161 AAPGLLRRVVVPVLVRDGQPCGGGGGGEV-------GTAAAQEKC 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	25/55 (45%)
		Engrail_1_C_sig	529..554	CDD:431338	7/32 (22%)
NKX2-8	NP_055175.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		13/55 (24%)
		Homeodomain	85..141	CDD:459649	25/55 (45%)