Protein Alignment inv and EN1

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 152/433 - (35%)
• Similarity: 197/433 - (45%)
• Gaps: 101/433 - (23%)

  Fly   184 MKQQMHLMAAARVNALTAAAAGKQ--LQMAMAAAAVATVPSGQDALAQLTATALGLGPGGAVHPH 246
            |::|.....:.|.:||.||||...  |.::::..|..:..||.|.    .:..:...|.....|.
Human     1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDG----DSVPVSPQPAPPSPPA 61

  Fly   247 QQLLLQRDQVHHHHHMQNHLNNNENLH--------------ERALKFSIDNILKADFGSR----- 292
            ...|   ..:.||.|:..|.......|              .|...|.|||||:.|||.:
Human    62 APCL---PPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPP 123

  Fly   293 ---LPKIGALSGNIGGGSV--SGSSTGSSKNSGNTNGNRSP-----LKAPKKSGKPLNLAQSNAA 347
               |....|..|..|||.|  ....|.:.::..:..|.|:|     |.||..:..|.:.:|. ||
Human   124 PQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQP-AA 187

  Fly   348 ANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSG----- 407
            |.:..|.:.:.|           .|.:::....:.|.......|....|.|:.|.:|..|
Human   188 AGAGASKAGNPA-----------AAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTK 241

  Fly   408 ----------------------EDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAA 450
                                  .||..|:||||||||||||||||||  ||.||.||
Human   242 YPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSG--PRTRKLKK-------- 296

  Fly   451 GGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQI 515
                   :|.|       .|||||||||:..||.|||.||..|||:||:|||.|:.||.|||:||
Human   297 -------KKNE-------KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQI 347

  Fly   516 KIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEE 558
            ||||||||||:||::|.||.|||.|||||||||||..:..::|
Human   348 KIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDE 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	40/55 (73%)
		Engrail_1_C_sig	529..554	CDD:431338	17/24 (71%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		22/105 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		18/47 (38%)
		Homeodomain	305..360	CDD:459649	39/54 (72%)
		Engrail_1_C_sig	361..391	CDD:431338	18/30 (60%)