Protein Alignment inv and EMX2

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_004089.1
• Gene: EMX2 / 2018
• HGNCID: 3341
• Length: 252
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 67/226 - (29%)
• Similarity: 88/226 - (38%)
• Gaps: 58/226 - (25%)

  Fly   327 SPLKAPKKSGKPLNLAQSNAAANSSLS-----FSSSLANICSN---SNDSNSTATSSSTTNTSGA 383
            |||.| .:|..|:..|..:.|.:|.::     |.|:.|.....   ||.....|.:.|.......
Human    20 SPLPA-SRSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAGRGVYSNPDLVFAEAVSHPPNPAV 83

  Fly   384 PVDLVKSPPPAAGAGATGASGKS-----GEDSGTPIVWPAW-VYCTRYSDRPSSGR--SPR---- 436
            ||..|  |||.|.|.....|..|     ......|..:..| ::..||......|.  ||.
Human    84 PVHPV--PPPHALAAHPLPSSHSPHPLFASQQRDPSTFYPWLIHRYRYLGHRFQGNDTSPESFLL 146

  Fly   437 ----ARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLT 497
                ||||                               ||.|||||.:||.||:|.|.:|.|:.
Human   147 HNALARKP-------------------------------KRIRTAFSPSQLLRLEHAFEKNHYVV 180

  Fly   498 EKRRQQLSGELGLNEAQIKIWFQNKRAKLKK 528
            ...|:||:..|.|.|.|:|:||||:|.|.|:
Human   181 GAERKQLAHSLSLTETQVKVWFQNRRTKFKR 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	29/55 (53%)
		Engrail_1_C_sig	529..554	CDD:431338	67/226 (30%)
EMX2	NP_004089.1	Homeodomain	155..211	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..252		67/226 (30%)