Protein Alignment inv and GSX2

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_573574.2
• Gene: GSX2 / 170825
• HGNCID: 24959
• Length: 304
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 74/286 - (25%)
• Similarity: 116/286 - (40%)
• Gaps: 61/286 - (21%)

  Fly   328 PLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPP 392
            ||..|    .||.::.|.....|..|.:..:..:|..|:..:|..:..:.:..:||.|      .
Human    34 PLGMP----PPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGV------T 88

  Fly   393 PAAGAGATGASGK----SGEDSGTPIVWPAWVYCTRYSDRPSSGRSPR----ARKPKKPATSSSA 449
            .|.|:|..||:|.    .|:.|..|   ....:|.|.:........|:    ..:|::|.::::|
Human    89 GAGGSGVAGAAGALPLLKGQFSSAP---GDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAA 150

  Fly   450 AGGGGGGVEKGE------------------------------AADGGGVPEDKRPRTAFSGTQLA 484
            |...........                              .:|...||..||.||||:.|||.
Human   151 AAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLL 215

  Fly   485 RLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKK-SSGTKNPLALQLMAQGLYNH 548
            .|:.||:.|.||:..||.:::..|.|:|.|:||||||:|.|.|| ..||:..........|
Human   216 ELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVG---- 276

  Fly   549 STIPLTREEEELQELQEAASAAAAKE 574
            |.:...|.|:|     ::.|.|:|.:
Human   277 SQVHYARSEDE-----DSLSPASAND 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	29/55 (53%)
		Engrail_1_C_sig	529..554	CDD:431338	4/24 (17%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..151		5/34 (15%)
		Homeodomain	203..259	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..304		6/20 (30%)