Protein Alignment inv and Hhex

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 283
• Identity: 67/283 - (23%)
• Similarity: 99/283 - (34%)
• Gaps: 87/283 - (30%)

  Fly   328 PLKAPKKSGKPLN---------LAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNT-SG 382
            ||.||....:|.:         |.:..||...:.:..|        .|.|.::..||..|.. ..
Mouse    17 PLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPS--------PNSSFTSLVSSYRTPVYEP 73

  Fly   383 APVDLVKSPPPAAG-AGATGASGKSG-------------------EDSGTPIVWPAWVYCTRYSD 427
            .||....|..|||. |.|.|.||..|                   :..|.|::|      :.:..
Mouse    74 TPVHPAFSHHPAAALAAAYGPSGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLW------SPFLQ 132

  Fly   428 RPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNE 492
            ||...|.                   ||.|.                   ||..|...|:.:|..
Mouse   133 RPLHKRK-------------------GGQVR-------------------FSNDQTVELEKKFET 159

  Fly   493 NRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAK---LKKSSGTKNPL-ALQLMAQGLYNHSTIPL 553
            .:||:...|::|:..|.|:|.|:|.||||:|||   ||:.:...|.. ||..:.........:|.
Mouse   160 QKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQGQDLPS 224

  Fly   554 TREE-EELQELQEAASAAAAKEP 575
            .:.: ..|...|.:.|.|:.::|
Mouse   225 EQNKGASLDRSQCSPSPASQEDP 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	22/58 (38%)
		Engrail_1_C_sig	529..554	CDD:431338	4/25 (16%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		31/134 (23%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		36/148 (24%)
		Homeodomain	143..195	CDD:459649	22/70 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		11/53 (21%)