DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and Ankrd35

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_345259.5	Gene:	Ankrd35 / 365881	RGDID:	1305527	Length:	990	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	187/975 - (19%)
Similarity:	328/975 - (33%)	Gaps:	280/975 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVGKA 93
            |.|||..||..||..|....:.|..:....|.:|.|.|||:|.:.|:.::       .::|....
  Rat    24 LLEAVQRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTIL-------LANGADIN 81

  Fly    94 AKGQKDKDKDKNKGRVKVAHQTIEAL--HNSALGIANNEGLSALHLAAQNGHNQSSRELLLAGAD 156
            :|.: |.....:...:....|.::.|  |.:.....:.|..|.||.||.:|  .:|..|||...:
  Rat    82 SKNE-DGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSG--CASSVLLLCDHE 143

  Fly   157 P--DVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRILLEA 219
            .  ||.:|.|.|||..|...|||.:...||......|.|:.:..:||.:.|..|..::..:||..
  Rat   144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEKGSAEVAELLLSH 208

  Fly   220 DARLGIKNAQGDCPMHIAIRKNYREIIEILNTPKKIRNR-----------------KEKPKEGGS 267
            .|..|..::.|...:|.|:....||:..:|......|.|                 .|.|.....
  Rat   209 GADAGAVDSLGHNALHYALGTQDRELWRLLQQALNRRRRGGRELVQHPDHASQASSSESPWRAEP 273

  Fly   268 RSDKDRDRERDVVDKGINWSPYGCHYFPDPRAFPSPKLETLPK-EPLKSGEQYFLDLAGHIHKGP 331
            ..:::.::..:...:...|.     :..:.|.....:.|.|.| :..|:....|:.|...|.:..
  Rat   274 EEEQEEEKGEERGSEEWRWK-----FEEEQRKVHQLEQELLQKTDECKARAAAFVSLENQIREQV 333

  Fly   332 VSVGNTCYC-----------GPFFRHIENKL--NCNRKSLKKYVHKTK----------------- 366
            ..:|   |.           ||..|...:.:  .|....|.:::.:.|
  Rat   334 QELG---YLLVQVPGAPRNQGPGLRPEGDGMEQGCPLNLLAEWIQELKKQQKATATINPTLVPKR 395

  Fly   367 -----------------------------ERLGHKVQALAIKTN-------DQIEQLTRTMIEDR 395
                                         |.:| |.....:.||       |..||:.....|..
  Rat   396 AEDLAPAETHYEVPGKFQPEQGLSQSPRSETIG-KATGQQLNTNGEQNLDLDNTEQVCADQKERA 459

  Fly   396 LRCESK---------------------RQHLSEFLRRGEPMRSTFDQ------------------ 421
            |...::                     |:.|:...|..:..|....:
  Rat   460 LAPGTEPAVTVGEPVGIAAMNQLLLQLREELAAVWREKDAARGALSRPVLEGALGTPRAEAAAAA 524

  Fly   422 -QNKSSRIERTMSRCRSLEL-----------------------LENNHEGGRLTNSRSVDVLEDQ 462
             :...:|:|:.:.|....::                       .....||.|...:|...:....
  Rat   525 WEKMEARLEKVLVRLDGAKMGLHVKPEVPAQGSRDGAPKIVQGCTKEQEGKRAPGARGEPLGAPG 589

  Fly   463 AVEAIVHRSAEVQVDSDSD--DDSNEARDEEEAEVG-DKDQVQEEAE-------------PEEHS 511
            ..:|:....|:.|::.:..  ..||....||..|:| ::.::|.|.:             ||...
  Rat   590 GEQALGGGLAKGQLEKEVSALRLSNSNLLEELEELGRERQRLQGELQSLTQKLQREFVPKPEAQV 654

  Fly   512 KLDELKLDFLKVSERLGVLLEKTTLIMERDSEQESKRQLSS----LSPPYNPHP---------RA 563
            :|.:|:       ..:|:|.|:  |.:|:::.::.:|:|:|    |...:|..|         |:
  Rat   655 QLQQLR-------RSVGLLTEE--LAIEKEATEKLRRRLASQTSGLQGLWNCFPPDLVGKGSARS 710

  Fly   564 ESAQLREDKESVNSPNFDEYANVIRRYPNSSETSNPSQNSNSWDWEASPTGSNPHPDYNKYYQRI 628
            .:|:..|:.::..|       .::.|:..|.:.....:..|.     ...||.|         ..
  Rat   711 TAAEPLEELQACIS-------TLVDRHLESQQVQARLEEENQ-----RLRGSLP---------PC 754

  Fly   629 GRGENMLNSV----IKALRKDASFADLGK---EETAVNETAEGMGGD-----KLLYKEQASEAAG 681
            |..|..|.:.    :.||.:     ||||   |..||..|..|...:     :|||  ||:|.
  Rat   755 GEPEASLKATASPQVAALEE-----DLGKLEEELRAVQATMSGKSQEICKLKQLLY--QATEE-- 810

  Fly   682 ISNLMKRQPLCLEDNYPVMSNLF----------------YSNPIMEYAEETEVRQNGNESMSKVE 730
            ::.|..|:...|..:.....:|.                |:....|.   |.:|....|...:.|
  Rat   811 VAELRAREAASLRQHEKTRGSLVAQAQAWGQELKVMLEKYNTACREM---TRLRDTAAEERRRSE 872

  Fly   731 ---IRNSEIKCLKKPNAGQVRDMVAQLQNTIDSNRQDSQTAHVIAA--RSHSRLNNNFHHLEGTS 790
               .|.:|    ::..||::|....|.:.|.:..::  :|.|:|.|  ...|::......||..|
  Rat   873 ELAARAAE----QERQAGEMRGRSEQFEKTAELLKE--KTNHLIGACRDKESKIKELLKKLEQLS 931

Fly 791 790
Rat 932 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	46/158 (29%)
		ANK repeat	24..55	CDD:293786	10/25 (40%)
		Ank_2	29..161	CDD:289560	37/135 (27%)
		ANK repeat	59..128	CDD:293786	14/70 (20%)
		ANK	126..249	CDD:238125	39/124 (31%)
		ANK repeat	130..161	CDD:293786	13/32 (41%)
		Ank_2	135..227	CDD:289560	32/93 (34%)
		ANK repeat	163..194	CDD:293786	11/30 (37%)
		ANK repeat	196..227	CDD:293786	8/30 (27%)
Ankrd35	XP_345259.5	ANK	<24..107	CDD:238125	22/90 (24%)
		ANK repeat	24..51	CDD:293786	10/26 (38%)
		ANK repeat	53..84	CDD:293786	9/37 (24%)
		Ank_2	58..150	CDD:289560	25/101 (25%)
		ANK	81..206	CDD:238125	35/127 (28%)
		ANK repeat	86..117	CDD:293786	4/30 (13%)
		ANK repeat	119..150	CDD:293786	13/32 (41%)
		Ank_2	124..216	CDD:289560	32/93 (34%)
		ANK repeat	152..183	CDD:293786	11/30 (37%)
		ANK repeat	185..216	CDD:293786	8/30 (27%)
		Ank_2	190..>250	CDD:289560	15/59 (25%)
		KASH_CCD	740..952	CDD:291334	49/224 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I4984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050