DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18011 and CG6689

DIOPT Version :9

Sequence 1:	NP_610559.1	Gene:	CG18011 / 36068	FlyBaseID:	FBgn0033491	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	142/749 - (18%)
Similarity:	249/749 - (33%)	Gaps:	206/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IPTREPSARIRNRAAAASNVTPDTSRSPEPPET--------PSTEDAVSKSEPKLVSKVADQEHF 187
            :|.....:..|::..||........|.|:.|:|        ..||:::....|
  Fly     5 VPNCRNFSDCRSKRNAAQQQRLGFFRFPKCPDTFKAWLAFCGYTEESLKLKNP------------ 57

  Fly   188 SVLIQNILDEEEAVVEDETAVKEESSEAVQVTEETEAPGQIVILN--SEAVTDTNPDENVYIYEH 250
            .:.|::..||     :.|.::|.|...|   .:.|..||.:..:|  .|:.:|....|......:
  Fly    58 CICIEHFKDE-----DIEGSLKFEMGLA---KKRTLRPGAVPCVNKSQESGSDRARKERSQRRRN 114

  Fly   251 EDVMDPNLDNVKVKPISCSSRLVAQAEESQSDDDIDEGETSNVVLFNFVDIKEKDEVDNIPEYLA 315
            ::::               :.|:|:.|......:....|..:|.|...|.:    |:|.:
  Fly   115 QELV---------------AELLAEEEAKLIHPEATSFEQDSVYLSETVTM----ELDPL----- 155

  Fly   316 TVVKTSFEKL-TFQWCTVCKHCSLKCPTFESLFSHLSKAHKSRRDVYECPIEGCNKELKGRKFLA 379
                :..||| ..|.|..|.:      .|.:.|        ..:|:::          .....|.
  Fly   156 ----SGEEKLEELQKCRTCYN------DFTADF--------RAKDLFD----------PANSVLL 192

  Fly   380 MHLVLL------HAPVAEIPIYGSCPECKLTFSNILQYNKHSCAHVIKKKRGFRSYCEMCSLEFP 438
            .|:.::      |.|  :.|.. .||.||......:.               ||..|....|:..
  Fly   193 FHIEVISGVWISHKP--DEPRL-MCPACKSALDQAID---------------FREMCISTELKLS 239

  Fly   439 SWKRFNFHSQFHLEKHRPRAC---FVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRTFRDPSV 500
            ..|......|...|...|.:.   .:.|...||::|:        |..|.
  Fly   240 QAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEI--------EDAGG--------------- 281

  Fly   501 FMEHNKSHANVSSTTYSCSECMANFESRGRLNGHMRAMHGSVISCELCSREFATEATYNIHMKKH 565
              :|.:..|  :|...:..|.:............:....|:.|..||..:...         |:.
  Fly   282 --DHVEDEA--TSDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTG---------KEK 333

  Fly   566 LIIEKDVHVCSTCGLLSDSRETLLAHVNSVKTACFGSKIDVELLRDA--------YVCEYCSSYF 622
            ..:.|...:.|.    ..::|.........::|...:|.:..|:|.|        :||:.|...|
  Fly   334 ARLRKGAPIASK----PKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAF 394

  Fly   623 KEKDCLQAH--RDSGVHKDGVFLCQPCGKEFPHMKLYRHHLRNYQQLRSDSTHRRLE-------I 678
            :....|:.|  |.:....   :.|..|.|.|     |..::||        .|.|:.       .
  Fly   395 RMSHNLRIHMLRHTRTKN---YQCTECPKTF-----YDAYMRN--------MHIRIRHRGETPFA 443

  Fly   679 CVYYMCDQENCTESYVNWNSLYTHKRRTHESASKQAEK--------SSKSAQEWVCQFCLKECRS 735
            |.:       |:|::....:...|:...|.:|.:...|        ..:.:..:.|:.|.|...|
  Fly   444 CGF-------CSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYAS 501

  Fly   736 KMSLSVHVARSHNNDNV-TCPLCNSSYKSHDALAKHHAYWHE--PIECPECFKIVKNRRNYDTHV 797
            |.:|..|: :||.:.|. .|..|:.||...:.| |.|...||  |::|..|.|....|.....|
  Fly   502 KYALGWHI-KSHTDANAYKCQRCSKSYSDPNKL-KRHEMTHEKRPLQCDVCLKGFYQRTRLREH- 563

  Fly   798 NVVHSNKKRYSCSVCQKGFYHKSEMEAH--QKLH 829
            .::|:.::.|.|.||...|.:|..|::|  .|:|
  Fly   564 ELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMH 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18011	NP_610559.1	PRK14950	<98..>184	CDD:237864	11/60 (18%)
		C2H2 Zn finger	488..508	CDD:275368	1/19 (5%)
		C2H2 Zn finger	518..538	CDD:275368	1/19 (5%)
		C2H2 Zn finger	545..565	CDD:275368	3/19 (16%)
		C2H2 Zn finger	575..596	CDD:275371	2/20 (10%)
		SFP1	<682..747	CDD:227516	13/72 (18%)
		C2H2 Zn finger	754..775	CDD:275368	7/20 (35%)
		C2H2 Zn finger	780..801	CDD:275368	5/20 (25%)
		C2H2 Zn finger	809..829	CDD:275368	8/21 (38%)
		C2H2 Zn finger	864..885	CDD:275368
		C2H2 Zn finger	891..917	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206	22/110 (20%)
		zf-AD	167..240	CDD:214871	18/114 (16%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..422	CDD:290200	6/25 (24%)
		C2H2 Zn finger	415..436	CDD:275368	9/33 (27%)
		C2H2 Zn finger	444..460	CDD:275368	3/22 (14%)
		C2H2 Zn finger	492..512	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	7/20 (35%)
		C2H2 Zn finger	547..567	CDD:275368	5/20 (25%)
		zf-met	574..597	CDD:289631	8/22 (36%)
		C2H2 Zn finger	575..591	CDD:275368	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100