DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1371 and nomo

DIOPT Version :9

Sequence 1:	NP_610551.1	Gene:	CG1371 / 36053	FlyBaseID:	FBgn0033482	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	XP_002662361.1	Gene:	nomo / 446115	ZFINID:	ZDB-GENE-040826-3	Length:	1208	Species:	Danio rerio

Alignment Length:	1261	Identity:	385/1261 - (30%)
Similarity:	626/1261 - (49%)	Gaps:	150/1261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GVFVILLIKL----FQNANAGEVEVVGCGGFIKSHAEIDFSRVEIKLLTKQGSLKDKTDCSPSNG 66
            |:..:.::.|    |...||.:..:||||||:||..||::|.:||||.|||||||.:|||:|.||
Zfish     3 GIKELAILTLSFLYFTFVNATDDILVGCGGFVKSDVEINYSVIEIKLYTKQGSLKYQTDCAPING 67

  Fly    67 YYFLPIYDKGDYLLSISPPPGWSFEPEQVELNFDGKTDVCSQGRDVNFVFKGFGITGQVALAAGG 131
            |:.:|:|||||::|.|.||.||||||..|:|:.||.||:|::.:|:||||.||.:.|.| |:.|.
Zfish    68 YFMIPLYDKGDFVLKIEPPSGWSFEPTTVDLHVDGVTDICTKEQDINFVFTGFSVLGTV-LSKGH 131

  Fly   132 --GARGVDVELR--SEQGEVRRTKSDANGVFSFTPIIPGNYVVKASHARWHFSKAEHKVVVVSGN 192
              |..||:|.||  .|...::...:.|.|.::|..::||:|.:.|||:.|...::...|||  .|
Zfish   132 LLGPAGVEVSLRKAGEDAVLQSVFTHAGGQYTFLKVLPGSYDITASHSSWTLEQSSTAVVV--SN 194

  Fly   193 TELPANS-LVVSGFDVVGRFDS-SSPLPGNLGVALYKKKGQSLVPKCETS--SPAPPNSVNSAYE 253
            ...||.: |||.|:||.|...| |.|:.| :...||    .:.|.|.:.|  :.||   |:.|..
Zfish   195 ENAPAAAPLVVKGYDVSGEVQSDSEPMKG-VSFLLY----SASVTKEDISGCAVAP---VDGALV 251

  Fly   254 SASS----CFSQLDKSGEYIFKNVPSGKYLLQAINLDSKLKLHLSPELLELEVGKDTLQIKDEFK 314
            ..:|    |.||..:.|.:.|..:|||:|.:.......::...::|..::.:|...:|.::..|:
Zfish   252 GDASLVYLCSSQSREDGTFSFPCLPSGEYTVVPYYRGERITFDVAPSRMDFKVEHSSLTLQPVFR 316

  Fly   315 ITGFTVSGRVLTSAGGEPLKSAVIKVNGKKVAETDAQGSYTLENLKAGTVNIEVESSQLQFSPLQ 379
            :.||:|.||||....||.:..||:.:|.:...||...||:.|||:..||..|......:.|.|:.
Zfish   317 VMGFSVMGRVLNGPDGEGVADAVVTLNNQIKVETKEDGSFRLENMTTGTYTINTHKELMFFEPVT 381

  Fly   380 VKAQINTASLPTIVPSAYEVCGKVVSPKSHNVGLTKIGST-------------------FHSSAS 425
            ||...:|..||.|:.:.:.|||        ::.:|::..|                   |..:..
Zfish   382 VKIAPSTPQLPDIITAGFSVCG--------HISVTRLPETVKQLGRYKVTLSAQRQDQGFFRTVE 438

  Fly   426 TNAETGNWCAFLPVGKYTIEVLTTDADKAAGVQFFPVQQQTEVRDAPVNGITFSQLRAKIRGELQ 490
            :::. |.:|..:..|.|:::|...:::..||:...|......:.|.||..:.|:|..|.:.|.:.
Zfish   439 SDSH-GAFCFQVKPGDYSVQVTLPESEVKAGLALQPHSLDISLVDRPVTDLLFTQFIASVSGSVS 502

  Fly   491 CLPDATATCTSAEVTLQALDATGQPTENKWKARAHRGKYVFKDMLPGPYELTIPQGNLCYESTRV 555
            ||    ..|....|:||.:...|:....:....:....:.|.::|||.|:::|.|...|::...|
Zfish   503 CL----VACGDLTVSLQPVSRQGERQNFQLSGSSETLTFTFGNVLPGKYKVSITQEEWCWKHKSV 563

  Fly   556 FLNVASAEEDAPPFVHKGYEVSIISSHRALMKYTHVTGPSEPKAPTESL---KIASGVNTFCVKK 617
            .::|..:..:...|...||.:....||...:::.     .:...| |::   .::.|||.||:.|
Zfish   564 EIDVLDSYVEGVEFRQTGYLLRCSLSHAITLEFF-----QDGSLP-ENVGVYNLSKGVNRFCLSK 622

  Fly   618 YGSYDFKLEGCH-------TYDESLPSKFITPEPDQLQTLIINAVA-HKTGVRVLSTEPTAD--- 671
            .|.|......||       ||:.|.||           .|.:.||. |.||  :::|:...|
Zfish   623 PGVYKVTPRSCHQFEQDYYTYNTSAPS-----------ILTLTAVRHHMTG--LITTDKMLDVTV 674

  Fly   672 SIKLVLESE-------------------------------SLGQEVITPVAES-HKVDGKFAYRY 704
            :||..:|||                               ..|.|...||.|. .::...|.|.:
Zfish   675 TIKSSIESEPALVLGPLRSNEEQRREQQLLEIAARKKERGEAGDEKSPPVEEKPEELREPFHYEF 739

  Fly   705 DTYLKPEQVLRITPVSDVLLFAPQQHE-IVGSSDCVDIAFNFVATRGLILRGKVVPAIKDAKITL 768
            ..:.:..:.:.:||.|...||.|.:.| .:...:|...........||.|.|:|.|.::..:||:
Zfish   740 SYWARAGEKITVTPSSKEFLFYPPEVEATITGENCPGRLVEITGRAGLFLTGQVAPTLEGVEITI 804

  Fly   769 SFPDQPELESLEVLTSVTGEFKFGPIEESLAFDLKAEKESYVFSDYNRQTASFSAHKLCEISVVV 833
            . ..:.....:.|||...|.:..||:.....:|:.|.||.:|.:....:|..|.|..|..::..:
Zfish   805 K-ESKATTPLITVLTDENGAYSVGPLHSDSQYDISASKEGFVLTPVEGKTGDFKAFALAGVTFEI 868

  Fly   834 KDEAGQTLGGVLLSLSGGESYRKNLVTGDNGAINFHSLSPSQYYLRPMMKEYKFEPNSKMIDIKD 898
            |.|.|..|.||||||||. |:|.||:|.|.|.:.|::|||.|||.:|||||::|||:::||.:::
Zfish   869 KAEDGVPLSGVLLSLSGA-SFRSNLLTQDTGLLTFNNLSPGQYYFKPMMKEFRFEPSAQMITVEE 932

  Fly   899 GETVSVTLVGKRFAYSIFGTVSSLNGDPFAGVNVQATADNSCPQQPEEATSEANGQYRIRGLQPG 963
            |:.:.:.:.|.:.|||.:|||.|:.||...||.|:|...:.|....|:..::..|::|:|||:||
Zfish   933 GQVLHIPITGFKTAYSCYGTVQSIGGDAEQGVAVEAVGQSECGMYSEDTVTDEEGRFRLRGLRPG 997

  Fly   964 CSYSVRVVPD-KEIVERSIPAQHTVKVANEDVRDINLVAISPLKIVDITARVTATLNEHYKTLRI 1027
            |:|::::..: .:.:||::|...|::|.|.|:..||::|...:...|::..| .|..||..||.:
Zfish   998 CNYNIQLRGEGNDHIERALPPHKTIEVGNTDIDGINIIAFRQINQFDLSGNV-ITSPEHLPTLWV 1061

  Fly  1028 VMYRKGNSDSPVFSQRVGTPVNPKARLNPGITVFFPRIPLDGKSYVVELQSTLSDKTYTYKLPST 1092
            .:|:..|.|:|..|..:|          ..:...|..:|.||:|||:.|.::||...|.:|||..
Zfish  1062 KLYKSDNLDNPFQSVSLG----------QSLFFHFQPLPRDGESYVLMLDTSLSRSQYDFKLPQV 1116

  Fly  1093 TFVADRGSVFVELEFKPEVRAAEADLNQNSISALVLIALVAIAFFKQDLATSFLSFVWSKLNDV- 1156
            :|.:......|.|.|.|:.:..:.|:.|.|..||.|..|:.:|.:..:.....|..:.|::..|
Zfish  1117 SFTSSGYHKHVTLTFNPKRKIPDQDVAQGSFIALPLTLLLLLAVYNHERVIPLLLQLVSQIQGVR 1181

  Fly  1157 ----------AADLAQRQKSKTQVRK 1172
                      ..|.|:|...:.:.|:
Zfish  1182 GLAQASGDGLPVDEAKRPSKRPKTRR 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1371	NP_610551.1	CarboxypepD_reg	120..198	CDD:290350	26/81 (32%)
		CarboxypepD_reg	319..>370	CDD:290350	20/50 (40%)
		Peptidase_M14NE-CP-C_like	841..905	CDD:304370	34/63 (54%)
		CarboxypepD_reg	914..>970	CDD:290350	22/55 (40%)
nomo	XP_002662361.1	CarboxypepD_reg	121..203	CDD:290350	27/84 (32%)
		CarboxypepD_reg	321..>368	CDD:290350	19/46 (41%)
		CarboxypepD_reg	422..480	CDD:290350	9/58 (16%)
		Cna_B	861..>913	CDD:283411	27/52 (52%)
		CarboxypepD_reg	951..>1008	CDD:290350	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575125
Domainoid	1	1.000	207	1.000	Domainoid score	I2849
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13810
Inparanoid	1	1.050	584	1.000	Inparanoid score	I971
OMA	1	1.010	-	-		QHG55641
OrthoDB	1	1.010	-	-		D361344at33208
OrthoFinder	1	1.000	-	-		FOG0005163
OrthoInspector	1	1.000	-	-		oto39192
orthoMCL	1	0.900	-	-		OOG6_105336
Panther	1	1.100	-	-	LDO	PTHR23303
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910