Protein Alignment CG1371 and NOMO2

DIOPT Version :10

• Sequence 1: NP_610551.1
• Gene: CG1371 / 36053
• FlyBaseID: FBgn0033482
• Length: 1199
• Species: Drosophila melanogaster
• Sequence 2: NP_001004060.1
• Gene: NOMO2 / 283820
• HGNCID: 22652
• Length: 1267
• Species: Homo sapiens
• Alignment Length: 1261
• Identity: 403/1261 - (31%)
• Similarity: 632/1261 - (50%)
• Gaps: 132/1261 - (10%)

  Fly     9 VILLIKLFQNANAGEVEVVGCGGFIKSHAEIDFSRVEIKLLTKQGSLKDKTDCSPSNGYYFLPIY 73
            |:||:.....|:..|..|||||||:||..||::|.:||||.||.|:||.:|||:|:|||:.:|:|
Human    19 VVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLY 83

  Fly    74 DKGDYLLSISPPPGWSFEPEQVELNFDGKTDVCSQGRDVNFVFKGFGITGQVALAAGG--GARGV 136
            ||||::|.|.||.||||||..|||:.||.:|:|::|.|:||||.||.:.|:| |:.|.  |..||
Human    84 DKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKV-LSKGQPLGPAGV 147

  Fly   137 DVELRS--EQGEVRRTKSDANGVFSFTPIIPGNYVVKASHARWHFSKAEHKVVVVSGNTELPANS 199
            .|.||:  .:.:::.|.:...|.|:|..::||:|.:.|:|..|...:|...|.|.:.|.. .|:.
Human   148 QVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNAN-AASP 211

  Fly   200 LVVSGFDVVGRFDS-SSPLPGNLGVALYKKKGQSLVPK-----CETSSPAP---PNSVNSAYESA 255
            |:|:|::|.|...| ..|:.| :...|:    .|||.|     |.. ||.|   |...:..|
Human   212 LIVAGYNVSGSVRSDGEPMKG-VKFLLF----SSLVTKEDVLGCNV-SPVPGFQPQDESLVY--- 267

  Fly   256 SSCFSQLDKSGEYIFKNVPSGKYLLQAINLDSKLKLHLSPELLELEVGKDTLQIKDEFKITGFTV 320
             .|::...:.|.:.|.::|||.|.:.......::...::|..|:..|..|:|:|:..|.:.||:|
Human   268 -LCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSV 331

  Fly   321 SGRVLTSAGGEPLKSAVIKVNGKKVAETDAQGSYTLENLKAGTVNIEVESSQLQFSPLQVKAQIN 385
            :||||....|:.:..||:.:|.:...:|.|.||:.|||:..||..|..:...|.|..:.:|...|
Human   332 TGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPN 396

  Fly   386 TASLPTIVPSAYEVCGKVV------SPKSHNVGLTKIGSTFHSSASTNAET---GNWCAFLPVGK 441
            |..|..||.:.:.|||::.      :.|..|.....:.|.....:....||   |::|.....|.
Human   397 TPQLADIVATGFSVCGRISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGT 461

  Fly   442 YTIEVLTTDADKAAGVQFFPVQQQTEVRDAPVNGITFSQLRAKIRGELQCLPDATATCTSAEVTL 506
            |.::|:..:|:..||:...|......|.|.||..:.|.|..|.:.|::.||.    ||....|||
Human   462 YKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLD----TCGDLLVTL 522

  Fly   507 QALDATGQPTENKWKARAHRGKYVFKDMLPGPYELTIPQGNLCYESTRVFLNVASAEEDAPPFVH 571
            |:|...|:....:...:.:...:.|.::|||.|:::|...:.|:::..:.:.|...:..|..|..
Human   523 QSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQ 587

  Fly   572 KGYEVSIISSHRALMKYTHVTGPSEPKAPTESLKIASGVNTFCVKKYGSYDFKLEGCH------- 629
            .||.:....||...::: :..|.........:|  :.|||.||:.|.|.|......||
Human   588 TGYMLRCSLSHAITLEF-YQDGNGRENVGIYNL--SKGVNRFCLSKPGVYKVTPRSCHRFEQAFY 649

  Fly   630 TYDESLPSKFITPEPDQLQTLIINAVAHKTGVRVLSTEPTAD---SIKLVLESESL--------- 682
            |||.|.||           .|.:.|:.|.. :..::|:...|   :||..::||..
Human   650 TYDTSSPS-----------ILTLTAIRHHV-LGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSV 702

  Fly   683 --------------------------GQEVIT--PVAES-HKVDGKFAYRYDTYLKPEQVLRITP 718
                                      |:|.:|  ||.|. .::.|.|:|.:..:.:..:.:.:||
Human   703 QELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTP 767

  Fly   719 VSDVLLFAPQQHE-IVGSSDCVDIAFNFVATRGLILRGKVVPAIKDAKITLSFPDQPELES--LE 780
            .|..|||.|...| :|....|...........||.|.|::.|.::..:|.:|   :....|  :.
Human   768 SSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVIS---EKGASSPLIT 829

  Fly   781 VLTSVTGEFKFGPIEESLAFDLKAEKESYVFSDYNRQTASFSAHKLCEISVVVKDEAGQTLGGVL 845
            |.|...|.:..||:...|.:.:.::||.||.:........|.|:.|..:|..:|.|..|.|.|||
Human   830 VFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVL 894

  Fly   846 LSLSGGESYRKNLVTGDNGAINFHSLSPSQYYLRPMMKEYKFEPNSKMIDIKDGETVSVTLVGKR 910
            |||||| .:|.||:|.|||.:.|.:|||.|||.:|||||::|||:|:||::::|:.:.:|:.|.|
Human   895 LSLSGG-LFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYR 958

  Fly   911 FAYSIFGTVSSLNGDPFAGVNVQATADNSCPQQPEEATSEANGQYRIRGLQPGCSYSVRVVPD-K 974
            .|||.:||||||||:|..||.::|...|.|....|:..::..|::|:|||.|||.|.|::..: .
Human   959 TAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGN 1023

  Fly   975 EIVERSIPAQHTVKVANEDVRDINLVAISPLKIVDITARVTATLNEHYKTLRIVMYRKGNSDSPV 1039
            :.:||::|....::|.|.|:.|:|::....:...|::..| .|.:|:..||.:.:|:..|.|:|:
Human  1024 DHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNV-ITSSEYLPTLWVKLYKSENLDNPI 1087

  Fly  1040 FSQRVGTPVNPKARLNPGITVFFPRIPLDGKSYVVELQSTLSDKTYTYKLPSTTFVADRGSVFVE 1104
              |.|.        |...:...||.:..||::|||.|.|||....|.|.||..:|.|......:.
Human  1088 --QTVS--------LGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHIT 1142

  Fly  1105 LEFKPEVRAAEADLNQNSISALVLIALVAIAFFKQDLATSFLSFVWSKLNDVAA----------- 1158
            |.|.|..:..|.|:.|.|..||.|..||.:|.:..|.....|..:.|:|..|.|
Human  1143 LIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDNSGP 1207

  Fly  1159 DLAQRQKSKTQVRKNEPINQREIEQM 1184
            :.|:||..|.:.|:...: |.|.:.|
Human  1208 EDAKRQAKKQKTRRTLRL-QEEFQLM 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1371	NP_610551.1	ClfA	<44..456	CDD:443959	148/433 (34%)
		ClfA	<828..>969	CDD:443959	70/140 (50%)
		CarboxypepD_reg	914..>970	CDD:433354	26/55 (47%)
NOMO2	NP_001004060.1	ClfA	102..>556	CDD:443959	142/469 (30%)
		ClfA	<811..>1011	CDD:443959	82/203 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1198..1219		4/20 (20%)