DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc2rk and DYRK3

DIOPT Version :9

Sequence 1:	NP_523674.1	Gene:	Cdc2rk / 36051	FlyBaseID:	FBgn0013435	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_003573.2	Gene:	DYRK3 / 8444	HGNCID:	3094	Length:	588	Species:	Homo sapiens

Alignment Length:	249	Identity:	80/249 - (32%)
Similarity:	128/249 - (51%)	Gaps:	24/249 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISG 97
            |..:.:|..:|..|      :|.|..:|:||:|.|.|..|.:..:.||||.||.::.   .....
Human   195 GAYIHVPRDHLAYR------YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR---FHRQA 250

  Fly    98 LREIMILKQCHHE------NIVRLREVVVGKSLDSIFLVMDFCEQDLASVL-DNMSQPFTESEVK 155
            ..||.||:....:      |::.:.|....:  :.:.:..:....||..:: .|..|.|:...|:
Human   251 AEEIRILEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIKKNKFQGFSVQLVR 313

  Fly   156 CITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKG--CIKVADFGLARMFSNPPKPMTPQMVTLWY 218
            .....:|::|..||...:||.|||..|:|:...|  ..||.||| :..|..  :.:...:.:.:|
Human   314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY--QKLYTYIQSRFY 375

  Fly   219 RAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAP 272
            ||||::||.| ::|.:|:|:|||||.|||.|:||.||..|..||..:::|||.|
Human   376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	77/237 (32%)
Cdc2rk	NP_523674.1	S_TKc	53..337	CDD:214567	76/229 (33%)
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305\|PubMed:23415227	1..188
		PKc_DYRK2_3	143..522	CDD:271126	80/249 (32%)
		S_TKc	209..522	CDD:214567	76/229 (33%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:29973724	468..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910