Protein Alignment Cdc2rk and CDK11A

DIOPT Version :9

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_001300825.1
• Gene: CDK11A / 728642
• HGNCID: 1730
• Length: 783
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 177/374 - (47%)
• Similarity: 246/374 - (65%)
• Gaps: 23/374 - (6%)

  Fly     2 SSLKSNDVDTNPAPDPQA--PITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSY 64
            |:|...|.    .||..|  ||..|..|       |..:|.  |.| ||.|.||:.|||:.||:|
Human   387 SALTEGDY----VPDSPALLPIELKQEL-------PKYLPA--LQG-CRSVEEFQCLNRIEEGTY 437

  Fly    65 GIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFL 129
            |:||||:|.:::||||||:::|::||:|.||:.||||..:.:..|.|||.:||:|||.::|.|::
Human   438 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYI 502

  Fly   130 VMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVA 194
            ||::.|.||.|:::.|.|||...|||.:.:|:|:.:|:||..:::|||||.||||::..|.:||.
Human   503 VMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVG 567

  Fly   195 DFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEI 259
            ||||||.:.:|.|..||.:||.||||||||||.:.::||||||:.|||.||||..|||.||||||
Human   568 DFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEI 632

  Fly   260 AQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKF-HMIGQSGRNLLNILFIYNPK 323
            .|::.:...||.|||.||||:::||.|:..|.|:.|||||..:| .::...|.:|:|....|.|.
Human   633 DQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 697

  Fly   324 TRATAEECLKSKYFVDPPQACDPGMMPTFP----QHRNNAAPAPAVQPP 368
            .|.:||:.||.:||.:.|...||.|.||:|    |.|.....:|  :||
Human   698 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSP--RPP 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	158/308 (51%)
		S_TKc	53..337	CDD:214567	145/284 (51%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..396		3/12 (25%)
		STKc_CDC2L1	420..711	CDD:173741	149/290 (51%)
		PLN00009	423..713	CDD:177649	149/289 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..783		9/26 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820