Protein Alignment Cdc2rk and CDK11A

DIOPT Version :10

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_001300825.1
• Gene: CDK11A / 728642
• HGNCID: 1730
• Length: 783
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 177/374 - (47%)
• Similarity: 246/374 - (65%)
• Gaps: 23/374 - (6%)

  Fly     2 SSLKSNDVDTNPAPDPQA--PITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSY 64
            |:|...|.    .||..|  ||..|..|       |..:|.  |.| ||.|.||:.|||:.||:|
Human   387 SALTEGDY----VPDSPALLPIELKQEL-------PKYLPA--LQG-CRSVEEFQCLNRIEEGTY 437

  Fly    65 GIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFL 129
            |:||||:|.:::||||||:::|::||:|.||:.||||..:.:..|.|||.:||:|||.::|.|::
Human   438 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYI 502

  Fly   130 VMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVA 194
            ||::.|.||.|:::.|.|||...|||.:.:|:|:.:|:||..:::|||||.||||::..|.:||.
Human   503 VMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVG 567

  Fly   195 DFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEI 259
            ||||||.:.:|.|..||.:||.||||||||||.:.::||||||:.|||.||||..|||.||||||
Human   568 DFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEI 632

  Fly   260 AQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKF-HMIGQSGRNLLNILFIYNPK 323
            .|::.:...||.|||.||||:::||.|:..|.|:.|||||..:| .::...|.:|:|....|.|.
Human   633 DQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 697

  Fly   324 TRATAEECLKSKYFVDPPQACDPGMMPTFP----QHRNNAAPAPAVQPP 368
            .|.:||:.||.:||.:.|...||.|.||:|    |.|.....:|  :||
Human   698 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSP--RPP 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	158/308 (51%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..396		3/12 (25%)
		STKc_CDC2L1	420..711	CDD:173741	149/290 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..783		9/26 (35%)