Protein Alignment Cdc2rk and CDK7

DIOPT Version :10

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_001790.1
• Gene: CDK7 / 1022
• HGNCID: 1778
• Length: 346
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 140/347 - (40%)
• Similarity: 199/347 - (57%)
• Gaps: 37/347 - (10%)

  Fly    53 FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRM---DQEKDGLPISGLREIMILKQCHHENIVR 114
            :|||:.:|||.:..||:|||..:|:|||:||:::   .:.|||:..:.||||.:|::..|.||:.
Human    12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76

  Fly   115 LREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLK 179
            |.:....||  :|.||.||.|.||..::.:.|...|.|.:|...|..|:.|:|||..:::|||||
Human    77 LLDAFGHKS--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLK 139

  Fly   180 VSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILG 244
            .:|||:.:.|.:|:||||||:.|.:|.:..|.|:||.||||||||.|.|.:...|||||.||||.
Human   140 PNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILA 204

  Fly   245 ELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQS 309
            ||||..|.|||:|::.||..|.:.||.|:|..||....||....|    :.:..: |..|:...:
Human   205 ELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF----KSFPGI-PLHHIFSAA 264

  Fly   310 GRNLLNI---LFIYNPKTRATAEECLKSKYFVDPPQACDPGMMPTFPQHRNNAAPAPAVQ-PPAD 370
            |.:||::   ||::||..|.||.:.||.|||                  .|...|.|..| |..:
Human   265 GDDLLDLIQGLFLFNPCARITATQALKMKYF------------------SNRPGPTPGCQLPRPN 311

  Fly   371 IPISDLLN-----VFIKRQRME 387
            .|:..|..     :.|||:|.|
Human   312 CPVETLKEQSNPALAIKRKRTE 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	128/305 (42%)
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	132/320 (41%)