Protein Alignment Cdc2rk and CDK6

DIOPT Version :10

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_001250.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 121/323 - (37%)
• Similarity: 185/323 - (57%)
• Gaps: 14/323 - (4%)

  Fly    45 GRCRPVSEFEKLNRVGEGSYGIVYRARDTRS-NEIVALKKVRMDQEKDGLPISGLREIMILKQC- 107
            |.||...::|.:..:|||:||.|::|||.:: ...||||:||:...::|:|:|.:||:.:|:..
Human     5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69

  Fly   108 --HHENIVRLREVVVGKSLD---SIFLVMDFCEQDLASVLDNMSQPFTESE-VKCITLQVLKALK 166
              .|.|:|||.:|......|   .:.||.:..:|||.:.||.:.:|...:| :|.:..|:|:.|.
Human    70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134

  Fly   167 YLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHT 231
            :|||..::|||||..|:|:|..|.||:|||||||::|. ...:|..:|||||||||:||. .::.
Human   135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVLLQ-SSYA 197

  Fly   232 TAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPY 296
            |.||:|:.|||..|:...|||..|:|::.||..|:|::|.|.|..||....||.....:.|.||.
Human   198 TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPI 262

  Fly   297 NNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYFVDPPQACDPGMMPTFPQHRNNA 359
            ......   |.:.|::||.....:||..|.:|...|...||.| .:.|...:....|..:|.:
Human   263 EKFVTD---IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD-LERCKENLDSHLPPSQNTS 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	119/315 (38%)
CDK6	NP_001250.1	STKc_CDK6	11..300	CDD:270846	112/293 (38%)