DRSC/TRiP Functional Genomics Resources

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Protein Alignment magu and nid2a

DIOPT Version :10

Sequence 1:NP_610548.2 Gene:magu / 36048 FlyBaseID:FBgn0262169 Length:613 Species:Drosophila melanogaster
Sequence 2:XP_005169904.1 Gene:nid2a / 322921 ZFINID:ZDB-GENE-030827-2 Length:1804 Species:Danio rerio


Alignment Length:710 Identity:143/710 - (20%)
Similarity:227/710 - (31%) Gaps:258/710 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 PVCGTDGQTYPTRCHLLRAQC-----------------GGHQVSLKYSGSCNACLEAVKFARR-Q 90
            |.|..:||..|.:||.....|                 |..:|:         |.:.|....| :
Zfish   937 PQCDEEGQYRPQQCHGSTGHCWCVDNRGQERAGTRTPPGSPRVN---------CDQPVHLRTRCE 992

  Fly    91 QERDP-----------GYFVPRCRKDGNFAAMQCYGNNG-CWCSDSQGRPIADDNKQFRRKG--- 140
            |.||.           |.|:|:|.::|.:...||:|:.| |||.|::|:         .|.|   
Zfish   993 QHRDSLQSGDGGVPAVGAFIPQCDEEGQYRPQQCHGSTGHCWCVDNRGQ---------ERAGTRT 1048

  Fly   141 -----KLRCRANRRDRRRLASHQ------------IG-----------YNPDTSASKGSSEAGST 177
                 ::.|....|.:.....|:            :|           |.|...       .|||
Zfish  1049 PPGSPRVNCDQPVRPKTHCEQHRDSLQSGDGGIPVVGAFIPQCDEEGQYRPQQC-------HGST 1106

  Fly   178 AHRTCSKSDRSQFNTNLMRMFRNEAQSFFR-----------QPSLSDSHILEWQFSKLDTNGNKL 231
            .|..|..|             |.:.::..|           ||..|.:|..:.:.|....:|...
Zfish  1107 GHCWCVDS-------------RGQERAGTRTPPGSPRVNCDQPVRSKTHCEQHRDSLQSGDGGVP 1158

  Fly   232 LDRQEIRELKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNRSAVVNLLASSA 296
            :....|.:..:  ....:|::|..:.| :|            |.|      .||..     ..:.
Zfish  1159 VVGAFIPQCDE--EGQYRPQQCHGSTG-HC------------WCV------DNRGQ-----ERAG 1197

  Fly   297 ATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDSATGYG------ 355
            ...||.|..                      ||........:..|:|.|:.:....|..      
Zfish  1198 TRTPPGSPR----------------------VNCDQPVRPKTQCEQHRDSLQSGNDGVPVVGAFI 1240

  Fly   356 ---GEED-----------------DSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQ 400
               .||.                 |::|.:...:||. |....:|     ..|.:...:.|  :|
Zfish  1241 PQCDEEGQYRTQQCHGSTGHCWCVDNRGQERAGTRTP-PGSPRVN-----CDQPVRPKTQC--EQ 1297

  Fly   401 SVTLEEQGHGGKSVL--FVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVK--NKRP 461
            .....:.|:.|..|:  |:|||..:|:|:..||:.  ||.:|||| ::.|:...||...  :.|.
Zfish  1298 HRDSLQSGNDGVPVVGAFIPQCDEEGQYRTQQCHG--STGHCWCV-DNRGQERAGTRTPPGSPRV 1359

  Fly   462 QCDESVAVRPMKGCTEPRKT------------QFLKELKAYLNTSLLPSSTTGSNSSMWKTD--- 511
            .||:  .|||...|.:.|.:            .|:.:...  .....|....||....|..|   
Zfish  1360 NCDQ--PVRPKTQCEQHRDSLQSGDGGVPAVGAFIPQCDE--EGQYRPQQCHGSTGHCWCVDSRG 1420

  Fly   512 DERIATLS------------FVYLDKNKNKSWDRREWKNFRDLVTSASHLRRCGKK------MPR 558
            .||..|.:            .:.....:.:|...| |:        ||.|::.|.:      :|:
Zfish  1421 QERAGTRTPPGSPRVNCDQPVIVPPTQRPESVCER-WR--------ASLLQQYGGQPDSQHYLPQ 1476

  Fly   559 YCDVNGD----KKISLAEWLNCLQATPRE-----SATTAKPAQSNETASPKFQGVNPVER 609
             ||..|:    :....:.:..|:.|..||     |....|||.....|||.   |:|:.|
Zfish  1477 -CDSAGEFNPVQCYGGSSYCWCVDANGREVPGTRSHDAVKPACIPTVASPT---VHPLPR 1532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
maguNP_610548.2 KAZAL_FS 38..77 CDD:238052 10/49 (20%)
TY 88..139 CDD:238114 18/63 (29%)
EFh_SPARC_SMOC 182..280 CDD:320013 17/108 (16%)
EF-hand motif 213..245 CDD:320013 4/31 (13%)
EF-hand motif 250..280 CDD:320013 6/29 (21%)
TY 396..463 CDD:238114 23/70 (33%)
EFh_SPARC_SMOC 475..577 CDD:320013 22/138 (16%)
EF-hand motif 512..544 CDD:320013 6/43 (14%)
EF-hand motif 549..577 CDD:320013 6/37 (16%)
nid2aXP_005169904.1 NIDO 113..278 CDD:214712
EGF_3 442..470 CDD:463759
nidG2 474..697 CDD:238158
EGF_3 710..746 CDD:463759
EGF_CA 748..790 CDD:214542
EGF_3 799..828 CDD:463759
Thyroglobulin_1 839..902 CDD:459665
Thyroglobulin_1 915..978 CDD:459665 9/40 (23%)
Thyroglobulin_1 991..1054 CDD:459665 19/71 (27%)
Thyroglobulin_1 1067..1130 CDD:459665 12/82 (15%)
Thyroglobulin_1 1143..1206 CDD:459665 14/88 (16%)
Thyroglobulin_1 1219..1282 CDD:459665 11/63 (17%)
Thyroglobulin_1 1295..1358 CDD:459665 22/67 (33%)
Thyroglobulin_1 1371..1434 CDD:459665 11/64 (17%)
TY 1453..1518 CDD:238114 17/74 (23%)
LY 1569..1606 CDD:214531
LY 1612..1654 CDD:214531
LY 1655..1699 CDD:214531
LY 1700..1742 CDD:214531
Blue background indicates that the domain is not in the aligned region.

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