DRSC/TRiP Functional Genomics Resources

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Protein Alignment magu and Nid2

DIOPT Version :10

Sequence 1:NP_610548.2 Gene:magu / 36048 FlyBaseID:FBgn0262169 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_001012005.2 Gene:Nid2 / 302248 RGDID:1311685 Length:1396 Species:Rattus norvegicus


Alignment Length:501 Identity:83/501 - (16%)
Similarity:114/501 - (22%) Gaps:269/501 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ARCV------LFVTWLAVFIATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRC---- 57
            |||:      .....|..|:.||   .|...:..||  :..|  :...:|.....::..||    
  Rat   881 ARCIHHGGSSFSCACLPGFVGTG---HQCSDVDECA--ENRC--HGAAICYNTPGSFSCRCQPGY 938

  Fly    58 HLLRAQCGGHQVSLKYSGSCNACLEAVKFARRQQ-ERDPGYFVPRCRKDGNFAAMQCYGNNG-CW 120
            |.....|....|..........|....::|:.|. .......:|:|...|||..:||:|:.| ||
  Rat   939 HGDGFHCASDTVPEDSISGLKPCEYQQRYAQAQHAHAGSRIHIPQCDDQGNFVPLQCHGSTGFCW 1003

  Fly   121 CSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRTCSKS 185
            |.|..|                              |::   |.|....||:             
  Rat  1004 CVDQNG------------------------------HEV---PGTQTPPGST------------- 1022

  Fly   186 DRSQFNTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKP 250
                                                                            |
  Rat  1023 ----------------------------------------------------------------P 1023

  Fly   251 RRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNG 315
            ..||                                            .||..|.          
  Rat  1024 PHCG--------------------------------------------PPPEPTQ---------- 1034

  Fly   316 HHRGHTNTIGTGVNPHSYSEDASGS-EEHEDNYEDSATGYGGEEDDSQGADLPSSRTHIPSLYML 379
                         .|.:..|....| .||          |||...|.|                 
  Rat  1035 -------------RPRTVCERWRESLLEH----------YGGTPRDDQ----------------- 1059

  Fly   380 NSKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTSTSYCWCVN 444
                                                :||||...|.:..:||:.  .:.:||||:
  Rat  1060 ------------------------------------YVPQCDDLGHFIPLQCHG--KSDFCWCVD 1086

  Fly   445 EDTGKSIPGT-SVKNKRPQCDESVA---VR--PMKGCTEPRKTQFL 484
            :| |:.:||| |.....|.|..:||   ||  |....|.|....||
  Rat  1087 KD-GRELPGTRSQPGTMPACIPTVAPPVVRPTPRPDVTPPAVGTFL 1131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
maguNP_610548.2 KAZAL_FS 38..77 CDD:238052 7/42 (17%)
TY 88..139 CDD:238114 15/52 (29%)
EFh_SPARC_SMOC 182..280 CDD:320013 3/97 (3%)
EF-hand motif 213..245 CDD:320013 0/31 (0%)
EF-hand motif 250..280 CDD:320013 3/29 (10%)
TY 396..463 CDD:238114 18/67 (27%)
EFh_SPARC_SMOC 475..577 CDD:320013 4/10 (40%)
EF-hand motif 512..544 CDD:320013
EF-hand motif 549..577 CDD:320013
Nid2NP_001012005.2 NIDO 108..274 CDD:214712
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..393
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..452
EGF_3 504..539 CDD:463759
nidG2 543..767 CDD:238158
EGF_3 779..815 CDD:463759
EGF_CA 817..859 CDD:214542
EGF_3 912..945 CDD:463759 7/36 (19%)
TY 960..1021 CDD:238114 20/93 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1013..1036 10/166 (6%)
Thyroglobulin_1 1040..1105 CDD:459665 27/130 (21%)
LY 1155..1193 CDD:214531
LDL-receptor class B 1 1175..1218
LY 1199..1241 CDD:214531
LDL-receptor class B 2 1219..1261
LY 1242..1286 CDD:214531
LDL-receptor class B 3 1262..1306
LY 1287..1329 CDD:214531
LDL-receptor class B 4 1307..1348
Blue background indicates that the domain is not in the aligned region.

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