DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12134 and Y54H5A.1

DIOPT Version :9

Sequence 1:	NP_001369072.1	Gene:	CG12134 / 36038	FlyBaseID:	FBgn0033471	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_498091.1	Gene:	Y54H5A.1 / 175701	WormBaseID:	WBGene00021899	Length:	453	Species:	Caenorhabditis elegans

Alignment Length:	303	Identity:	55/303 - (18%)
Similarity:	103/303 - (33%)	Gaps:	94/303 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EDEEDIGDEDTCS---AQDLAAEFQLKYKPQDEVSVSLQREYVLSLAADQGFSRM---------- 71
            :::|:.||:...|   ::|..||.:.|.:|         :.:.:|:....|.:|:
Worm   126 KEKENKGDDSDTSEDESEDEDAEEEKKREP---------KMHAVSIPHYGGINRIRSDRLGDSTV 181

  Fly    72 -AAGLSNSAVHIYNLD---------SGAGKLENFSYLPPTDSPQSVSICGVRFLDEGPHNILVGT 126
             |.......|.::|:.         ||..|.|    :...|.|        .|.:.|      ..
Worm   182 CACWSDQGRVQVWNITDALNYTHGMSGESKTE----VQKIDRP--------LFTNNG------SG 228

  Fly   127 TDGYVRLYDLRLRGEQARFKYTQHPNVPPVPKSLSCFDRNANGRIICCGTEQFHSNAFLVFFDVR 191
            .:||...:.....|:.                        |.|.||          ..:..:.::
Worm   229 KEGYGLAWSSLKTGDL------------------------ATGDII----------KKIYLWQMK 259

  Fly   192 ERQQMGV---YFESHEDDITSLRFHAQNPDLLATGSVDGLVNVFDVKEPDEDEALLNTFNT-ESS 252
            |..|..|   ....|:..:..|.:......|||:.|.||.:.::|.:...:|..:...... ||.
Worm   260 EGGQWAVGANPLTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTRSAPKDACVCTVQKAHESD 324

  Fly   253 VARLAWHRNVYDKDIISCVTTTGDFKSYECEE---GDEVASFE 292
            |..::|:|:   :::|......|:.|.:..:.   |..||.|:
Worm   325 VNVISWNRH---ENLIVSGGDDGELKIWSLKTIQFGQPVALFK 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12134	NP_001369072.1	WD40	56..384	CDD:421866	46/264 (17%)
		WD40 repeat	59..101	CDD:293791	10/61 (16%)
		WD40 repeat	108..146	CDD:293791	5/37 (14%)
		WD40 repeat	153..201	CDD:293791	7/50 (14%)
		WD40 repeat	207..248	CDD:293791	9/40 (23%)
		WD40 repeat	300..353	CDD:293791
		WD40 repeat	359..390	CDD:293791
Y54H5A.1	NP_498091.1	CAF1C_H4-bd	54..122	CDD:372002
		WD40	182..>401	CDD:392136	43/238 (18%)
		WD40 repeat	232..273	CDD:293791	9/74 (12%)
		WD40 repeat	278..318	CDD:293791	9/39 (23%)
		WD40 repeat	326..364	CDD:293791	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910