Protein Alignment CG1513 and OSBPL11

DIOPT Version :10

• Sequence 1: NP_610534.3
• Gene: CG1513 / 36028
• FlyBaseID: FBgn0033463
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_073613.2
• Gene: OSBPL11 / 114885
• HGNCID: 16397
• Length: 747
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 271/826 - (32%)
• Similarity: 412/826 - (49%)
• Gaps: 170/826 - (20%)

  Fly     6 GSAPSLGPPQSGSGGSG----------------------TLEGTLSKWTNVMKGWQYRFFVLDEN 48
            |.|.::.|.::.|.|.|                      .:.|.|.|:||::.|||||||||:..
Human    21 GQATAVTPNKNSSCGGGISSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNE 85

  Fly    49 AGLLSYYTSKDKMIKGVRRGCVRLKDALIGIDDQEDNTFTI-TVDHKTFHFQARHNEEREQWVRR 112
            ||||.|:.::... ....||.::|..|:|...|::.:|||: ....:.:..:|...:||:.||.|
Human    86 AGLLEYFVNEQSR-NQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSR 149

  Fly   113 LEDTIRRHAN---------RSRLWDSQSAFYIAGGYTKEGGGSGTGGRRPNHLELVARRVSEADA 168
            |:...:.|..         :||      :|.:|     ....|....|||:...:....|..:.
Human   150 LQICTQHHTEAIGKNNPPLKSR------SFSLA-----SSSNSPISQRRPSQNAISFFNVGHSK- 202

  Fly   169 YLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHI----KHSIVSLQIAKNMAHPING 229
             ||.:.::|||....:.|:.:                |:.|.    :..|..::......| ::.
Human   203 -LQSLSKRTNLPPDHLVEVRE----------------MMSHAEGQQRDLIRRIECLPTSGH-LSS 249

  Fly   230 IYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDDEEDSATENATTAPLGLI 294
            :........:||.:|.. .:..|.::      :.|:.....||.|         .:.||  :..:
Human   250 LDQDLLMLKATSMATMN-CLNDCFHI------LQLQHASHQKGSL---------PSGTT--IEWL 296

  Fly   295 VPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEKAPDGFANAEPVAVGDSV 359
            .|..|.|:     .:.:..|.||.:..|.|:.                .|:    .:|||....:
Human   297 EPKISLSN-----HYKNGADQPFATDQSKPVA----------------VPE----EQPVAESGLL 336

  Fly   360 APQTLPE---IDESVADADTSIKTARTAVSSRSASYDNGIDYDALYEEEEETDL-SMEAHGSMIT 420
            |.:  ||   .|:.:.|..                            :.:|.|| ::|...|:|.
Human   337 ARE--PEEINADDEIEDTC----------------------------DHKEDDLGAVEEQRSVIL 371

  Fly   421 HLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRDRIVQVCRWYMSAY 485
            |||||:|:|||||:|||||||||:|||||||||:.:||||||.|::.....||:::...:|::::
Human   372 HLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSF 436

  Fly   486 HAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEV----------RDGPVPWCRRDQLT---- 536
            |.|||.|:||||||||:||.|.|.|.:|. |:.|..|          ...|:   ..:.||
Human   437 HEGRKGAIAKKPYNPIIGETFHCSWKMPK-SEVASSVFSSSSTQGVTNHAPL---SGESLTQVGS 497

  Fly   537 ------FLAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEE 595
                  |:|||||||||:|.||||...:|:...|||||||||||:||||..:|||:::|::..||
Human   498 DCYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEE 562

  Fly   596 YIVTFPNGYGRSILTVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKRNRVSAEVYAPSEKKP 660
            |..:.|..|.||||||||:||||.|.:.|.::||.|::.|.||||||||.:||:|||........
Human   563 YTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKHNITNTV 627

  Fly   661 FVSITGEWSGLMEAKWHDKNKTEVFVDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAGLKFNDI 725
            ...:.|||:.::|..:  .|....:||:.::.:.||:|||:.:||.:||||:||.||..|:.::|
Human   628 VCRVQGEWNSVLEFTY--SNGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEI 690

  Fly   726 ERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFKPVGDNWIYAKPL 771
            ::||..|..:|::||.:.:.|.|....|:.|:|...||.|:|.|||
Human   691 DKATEHKHTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPL 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	36/110 (33%)
		Oxysterol_BP	421..767	CDD:460126	173/365 (47%)
OSBPL11	NP_073613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		6/28 (21%)
		PH_ORP10_ORP11	61..167	CDD:270106	36/106 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..188		6/40 (15%)
		Oxysterol_BP	372..738	CDD:460126	177/371 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	689..714		8/24 (33%)