Protein Alignment CG1513 and OSBPL8

DIOPT Version :10

• Sequence 1: NP_610534.3
• Gene: CG1513 / 36028
• FlyBaseID: FBgn0033463
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_047284202.1
• Gene: OSBPL8 / 114882
• HGNCID: 16396
• Length: 925
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 207/765 - (27%)
• Similarity: 318/765 - (41%)
• Gaps: 199/765 - (26%)

  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDA-LIGIDDQEDNTF 87
            :.|||..||   |.|    .||.... ||.|.|.|:    |...|.|.|... :|....::|.
Human   193 IRGTLKSWT---KLW----CVLKPGV-LLIYKTQKN----GQWVGTVLLNACEIIERPSKKDG-- 243

  Fly    88 TITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRR 152
                    |.|:..|..|:..|..:                         |...|..||.|....
Human   244 --------FCFKLFHPLEQSIWAVK-------------------------GPKGEAVGSITQPLP 275

  Fly   153 PNHLELVARRVSEADA-----YLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKH 212
            .::  |:.|..||:|.     .|:|.:                    ||.:|          :|.
Human   276 SSY--LIIRATSESDGRCWMDALELAL--------------------KCSSL----------LKR 308

  Fly   213 SIVSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDD 277
            ::    |.:...|.:        :.:|.|:..:...:...||:.:|. ...|....|.:....|.
Human   309 TM----IREGKEHDL--------SVSSDSTHVTFYGLLRANNLHSGD-NFQLNDSEIERQHFKDQ 360

  Fly   278 EEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEK 342
            :                    .||....:|:..:..:.....:|.|         .|:.:.|.|:
Human   361 D--------------------MYSDKSDKENDQEHDESDNEVMGKS---------EESDTDTSER 396

  Fly   343 APDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYE--EE 405
            ..|.:...|||        :.|.|                |..:.:|        ::.|.|  |.
Human   397 QDDSYIEPEPV--------EPLKE----------------TTYTEQS--------HEELGEAGEA 429

  Fly   406 EETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDP 470
            .:|:...|.:.|:|..||.||:.||||:||||||||||.||.|:..:||:.|.|...:.:..::|
Human   430 SQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENP 494

  Fly   471 RDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQL 535
            ..|:.:|.:||:|.::  :|....||||||||||.|:|.|..|                 |.:..
Human   495 YFRLKKVVKWYLSGFY--KKPKGLKKPYNPILGETFRCLWIHP-----------------RTNSK 540

  Fly   536 TF-LAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVT 599
            || :||||||||||||||..:.......:..:..||||.|.|:.....||..:|.::|.|:|::|
Human   541 TFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMT 605

  Fly   600 FPNGYGRSIL--TVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKR--NRVSAEVYAPSEKKP 660
            .|..:.:.||  |:. :||||:|.|.|.::||.|.:||..|||.|...  |::|.::  ...|:.
Human   606 MPYAHCKGILYGTMT-LELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKL--KLGKEV 667

  Fly   661 FVSITGEWSGLMEAKWHDK--NKTEVF----VDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAG 719
            ..::.|.|..  |....||  :.:|||    .|:.:..:.:..|: ..||.::||.::|:.||..
Human   668 LATLEGHWDS--EVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVK-FEEQGDFESEKLWQRVTRA 729

  Fly   720 LKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFK--PVGDNWIY 767
            :...|...||..|:|:|:.||..|:.||..:..|..|.|:  |:...|.|
Human   730 INAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHY 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	25/101 (25%)
		Oxysterol_BP	421..767	CDD:460126	132/358 (37%)
OSBPL8	XP_047284202.1	PH_OPR5_ORP8	178..307	CDD:270103	40/192 (21%)
		Oxysterol_BP	443..789	CDD:460126	134/362 (37%)