DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd4-1 and SMYD3

DIOPT Version :10

Sequence 1:NP_610500.2 Gene:Smyd4-1 / 35985 FlyBaseID:FBgn0033427 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001161212.1 Gene:SMYD3 / 64754 HGNCID:15513 Length:428 Species:Homo sapiens


Alignment Length:353 Identity:80/353 - (22%)
Similarity:130/353 - (36%) Gaps:110/353 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 GEILTDPGPRGRYMVAKEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPCPNCHQRVV 280
            ||:|....|.. |.|.|.  |:|  :..:|  |.:..|:|:.|.||                ||.
Human    27 GELLFRSDPLA-YTVCKG--SRG--VVCDR--CLLGKEKLMRCSQC----------------RVA 68

  Fly   281 -YCSRKCREAHSAIHKFECAA-------YRKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAK 337
             |||.||::.....||.||..       |..|.:||||  .:..:|                   
Human    69 KYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLG--RVVFKL------------------- 112

  Fly   338 GMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFH 402
                    :...|.|||....:......:::|.:...|.|...::   ..|.:::|......|  
Human   113 --------MDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVM---TFQHFMREEIQDASQ-- 164

  Fly   403 SLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHN 467
             ||.:.:.::.....:...|.   :.|..:.:  :|||:.|.                       
Human   165 -LPPAFDLFEAFAKVICNSFT---ICNAEMQE--VGVGLYPS----------------------- 200

  Fly   468 LSHSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQR 532
                          :||.||:|:|:....|:|..::..|.:||..|||:..|| :|...:.: :|
Human   201 --------------ISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICY-LDMLMTSE-ER 249

  Fly   533 SHPLKAIYKFECTCAKCTRTDPDQNYLS 560
            ...|:..|.|||.|.:|...|.|.:.|:
Human   250 RKQLRDQYCFECDCFRCQTQDKDADMLT 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smyd4-1NP_610500.2 SET 217..>252 CDD:394802 10/34 (29%)
zf-MYND 258..298 CDD:460312 12/40 (30%)
SET <359..549 CDD:394802 38/189 (20%)
SMYD3NP_001161212.1 SET_SMYD3 5..268 CDD:380980 77/342 (23%)
zf-MYND 49..87 CDD:460312 16/55 (29%)
C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000269|PubMed:25738358 272..428 2/6 (33%)

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