Protein Alignment Smyd4-1 and SMYD2

DIOPT Version :10

• Sequence 1: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_064582.2
• Gene: SMYD2 / 56950
• HGNCID: 20982
• Length: 433
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 95/479 - (19%)
• Similarity: 173/479 - (36%)
• Gaps: 153/479 - (31%)

  Fly   213 KSLG--EILTDPGPRGRYMVAKEAISKGNVIFS-----------ERAS----CFVPLEQLLICQQ 260
            :.||  |....|| :||.:.|.:....|:::||           ||.:    ||...|.|..|.:
Human     4 EGLGGLERFCSPG-KGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGR 67

  Fly   261 CAATLMSAPIPCPNCHQRVVYCSRKCREAHSAIHKFECAAYRKDILRLLGISHLALRLLLTYIPY 325
            |               ::..||:.:|::....:||.||:.                  ::.:...
Human    68 C---------------KQAFYCNVECQKEDWPMHKLECSP------------------MVVFGEN 99

  Fly   326 IRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLY 390
            ..|......:|:.:.::.::..|.|.|     :.|......|.||:..:|:       .:|:|..
Human   100 WNPSETVRLTARILAKQKIHPERTPSE-----KLLAVKEFESHLDKLDNEK-------KDLIQSD 152

  Fly   391 LKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQ 455
            :.....||.:....|.:        .:|::.|| |:..||..        :|.:|
Human   153 IAALHHFYSKHLGFPDN--------DSLVVLFA-QVNCNGFT--------IEDEE---------- 190

  Fly   456 KPRHLKRGQLHNLSHSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCY 520
                        |||   :.:...|.::|.||:|.|::...:.|......|.::|..|||:|..|
Human   191 ------------LSH---LGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY 240

  Fly   521 ------TMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPDQNYLSFHRYRCEKPNCRQEFLPDA 579
                  |.|        |:..|:..|.|.|.|.:||..|.|:..:...  :...|       |.|
Human   241 IDLLYPTED--------RNDRLRDSYFFTCECQECTTKDKDKAKVEIR--KLSDP-------PKA 288

  Fly   580 KVQQNNLRWWLRCNAEKPITCTVCHEL---QHFAWYNEFLGLIGSSADSSKRQALFKAFDDLDKW 641
            :..::.:|:          ...|..|.   :|:...:|.|.:...|     ::.:...|:|.:.:
Human   289 EAIRDMVRY----------ARNVIEEFRRAKHYKSPSELLEICELS-----QEKMSSVFEDSNVY 338

  Fly   642 LVDHHSLKRIMAEELVTACFYEID 665
            ::  |.:.:.|.     .|.|..|
Human   339 ML--HMMYQAMG-----VCLYMQD 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	13/49 (27%)
		zf-MYND	258..298	CDD:460312	7/39 (18%)
		SET	<359..549	CDD:394802	43/195 (22%)
SMYD2	NP_064582.2	SET_SMYD2	7..269	CDD:380979	74/357 (21%)
		zf-MYND	52..90	CDD:460312	11/52 (21%)