back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and Smyd5

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	95/437 - (21%)
Similarity:	144/437 - (32%)	Gaps:	166/437 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EILTDPGPRGRYMVAKEAISKGNVIFSERA------------------SCFVPLEQLLICQQCAA 263
            ||...|| :||.|:|.:..:|..|||.|..                  .|..|||.:|...:..|
  Fly     5 EIRELPG-KGRAMIATKNFAKDEVIFEEEPFVSRQFSWNVAYGYAACDHCMRPLETVLENVRRLA 68

  Fly   264 TLMSAPIP----------------CPNCHQRVVYCSRKC-REAHSAIHKFEC-AAYRKDILRLLG 310
            :.....:|                ||.|  :|.|||..| .||....|:..| .|:..|....:.
  Fly    69 SDPKVEVPLLQHDPTAQWVAQFTQCPRC--KVRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPIN 131

  Fly   311 ISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDE 375
            :.:...:         :.|....|.:..:...:|.|.::..:.|   |:|..|:....|....::
  Fly   132 VLNETWK---------KMHYPPETGSIMLIVRLMALYQQSTKKE---EFLEQLQSFQSLIVNREQ 184

  Fly   376 ELNYHILCAN----LLQLYL--------KEHTDFY--DQFHSLPA------------SIEDWQLI 414
            ::.:.:|..|    :.||||        :|.:.|.  |.|.:|.|            .:..|...
  Fly   185 KIYHKMLGENFEQQMEQLYLAFCNAFTGEEFSIFKTPDAFKTLMAILGTNSQGIATSVLSQWVAK 249

  Fly   415 ISALIL--------------------RFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRH 459
            :|.|.|                    .|||:.|.|            |.....:||.::
  Fly   250 VSDLPLTDSEKEQLDTVIDGLYAKVGEFAGEFLNN------------EGSGLYLLQSKI------ 296

  Fly   460 LKRGQLHNLSHSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNY--------AAKDILEGEEI 516
                                      ||:|.|      :.||...|        |...|.:||||
  Fly   297 --------------------------NHSCVP------NACSTFPYSNDIVVLKALAPIQQGEEI 329

  Fly   517 FNCYTMDYRNSLKLQRSH-----PLKAIYKFECTCAKC--TRTDPDQ 556
              |  :.|.:...|:||.     .|:..|.|.|.|.||  ..:|||:
  Fly   330 --C--ISYLDECMLERSRHSRHKVLRENYVFICQCPKCRAQASDPDE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	14/52 (27%)
		zf-MYND	258..298	CDD:460312	13/56 (23%)
		SET	<359..549	CDD:394802	50/248 (20%)
Smyd5	NP_650955.1	SET_SMYD5	3..366	CDD:380919	92/429 (21%)
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:460312	11/32 (34%)

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-