DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and Smyd4-2

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	765	Identity:	169/765 - (22%)
Similarity:	283/765 - (36%)	Gaps:	198/765 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NYKDEFETFKSLASMPADILQIF--QKLALDLLQDLE--QPVDRKGCAERSKNLREEGNLMFKES 80
            ||      |..|.|..|.:|.||  :::...:|..||  |||.::..|..|...|.:.:.::..|
  Fly    42 NY------FGKLKSNAARVLSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMS 100

  Fly    81 ASGSSKDS------VLKACRLYSEAVFEA--ENA---VEE---LSLAFANRGIALQEYGYYREAY 131
            .||..::|      .|.|..|   ||..|  .||   ::|   |:||:.:|...|...|....|.
  Fly   101 GSGDGEESRELLQQALMAANL---AVMRAPDRNADPVLDEGLTLALAYRSRASILIRLGEGEAAL 162

  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESF----EQQLEDLKQ 192
            :|...|:..|...:......::.|      |..|.:.|.......|::.|..    ...:...::
  Fly   163 NDLKLAINFGLELKSSVDYYLKMA------KAYAVMGEPARAEISLKIAEKMPGCDATHIALCRK 221

  Fly   193 KLELLKNQPREQETQGKVVDKSLGEI-----------LTDPGPRGRYMVAKEAISKGNVIFSER- 245
            :|..:|.:|:| .|..:|...:.||.           |.:...:||::||.|.:..|:|:..|.
  Fly   222 ELSSVKPKPKE-ATSEQVPQLAHGESAELVGASKVVRLVETKDKGRFVVANEGLRTGDVLLFEEP 285

  Fly   246 -ASCFVPLEQLLICQQCAATLMSAPIPCPNCHQRVVYCSRKCR-EAHSAIHKFECAAYRKDILRL 308
             |:|..|......|..|...| ..|:.|.:| ..:.:||.:|. ||.|:.|:|||.  ..|::..
  Fly   286 VAACLEPSYFGTHCHHCFKRL-HTPVSCLHC-SGIAFCSAQCMGEACSSYHRFECE--YMDLMIG 346

  Fly   309 LGIS---HLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLD 370
            .|:|   .:||| :.|..|.:.   |.:.:|..::|.:.:    .||.....:|||...|...|.
  Fly   347 SGMSILCFIALR-IFTQAPSLE---QGLATANLLFEHLCS----HEEDRQPDDYLRRALMSGFLL 403

  Fly   371 QAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDA 435
            :.:.:.|.:.           :..|:..:     |.::|   |.::..:|.....|..|.|
  Fly   404 RILQKSLYFG-----------RRKTEGVN-----PTAVE---LQVATALLGLLQVLQYNAH---- 445

  Fly   436 LLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHSDPITAINLPYL--------SLCNHACEPS 492
                       .:.|.::.::         |....|..:      ||        |..||.|.||
  Fly   446 -----------QIYQTQVTEE---------HRFDGSKTV------YLAAGLYGTGSYFNHECWPS 484

  Fly   493 IRTKFDGCSVVNYAAKDILEGEEI-FNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPDQ 556
            ....|.|..:|..|.:.....|.: .|...:..:|:|| :|...|:..|.|.|:|..|....|..
  Fly   485 TACHFVGKKLVLTATRPHRANELVAVNYGPIFIKNNLK-ERQRSLRGRYSFSCSCMACQENWPLL 548

  Fly   557 NYLSFH-RYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCHELQHFAWYNEFLGLIG 620
            ..|... |:.|...||            :||..:.: :..|.:.|..|.:
  Fly   549 QKLDKQVRFWCTSANC------------SNLLKFPK-DLAKDVRCPRCRK--------------- 585

  Fly   621 SSADSSKRQALFKAFDDLDKWLVDHHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARIIRKQ 685
               :.|.::::                .|.|..|||                  |.:.||.:..|
  Fly   586 ---NISLKESV----------------AKMIKIEEL------------------YREAARAMEAQ 613

  Fly   686 LEGIAAQCGDNSTE---YIARMTYLWDIIAQK---KCRTDRKELLEMKGK 729
            ....|.:....|.:   .:|.:.:...|:||:   ||.:|.....:.:||
  Fly   614 KTVEAIELFKESLDMFFQVAALPHKDTIVAQQSLHKCLSDTGTTFKKEGK 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	14/40 (35%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	17/87 (20%)
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150	14/68 (21%)
		zf-MYND	299..338	CDD:280009	14/40 (35%)
		SET	<474..513	CDD:279228	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5130
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880