Protein Alignment Smyd4-1 and Smyd4-3

DIOPT Version :10

• Sequence 1: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_725048.1
• Gene: Smyd4-3 / 36234
• FlyBaseID: FBgn0033633
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 690
• Identity: 175/690 - (25%)
• Similarity: 259/690 - (37%)
• Gaps: 177/690 - (25%)

  Fly    63 AERSKNLREEGNLMFKESASGSSK-DSVLKACRLY--SEAVFEAENAVEELSLAFANRGIALQEY 124
            |.::.:|..|    .||.|:.:.| ...|:|..||  |.....:|| |.|:.:..|||...|...
  Fly    67 AGKNASLAAE----IKERATSAFKAKKWLEAMMLYTRSYVALPSEN-VAEIRVVLANRSATLYHM 126

  Fly   125 GYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLK----KIASLEEHLDYLGQLQLKESFEQ 185
            ..|:|...|...||:..|.:.|.:|:..|||.|...||    .|.|.::.:..:....|......
  Fly   127 QKYQECLIDIKRALDLSYSKDLIYKLYERQARCYMALKDYPHTIDSFKKCITAMDDSTLASDKRA 191

  Fly   186 QLE-DLKQKLELLKNQPR------EQETQGKVVDKS----LGEILTDPGPR-------GRYMVAK 232
            :|. |....:::|:|.||      :|:.|...:|::    |......|..|       ||:..|.
  Fly   192 KLNLDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARAS 256

  Fly   233 EAISKGNVIFSERASCFVPLEQL--LICQQCAATLMSAPIPCPNCHQRVVYCSRKCR-EAHSAIH 294
            ..:..|..:..||....|.||:.  ..|:.|....: .|:.||.|.. |:|||.:|| ||....|
  Fly   257 ADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTV-VPVACPRCAD-VLYCSEQCREEASKKYH 319

  Fly   295 KFECAAYRKDILRLLGIS---HLALRLL----LTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEE 352
            |:||...  .|:...|.|   |:|||::    |.|...::|.:.|
  Fly   320 KYECGIV--PIIWRSGASINNHIALRIIASKPLDYFLKLKPTIDE-------------------- 362

  Fly   353 SENAPEYLRSL-----RMVSQLD--QAIDEELNY--HILCANLLQLYLKEHTDFYDQFHSLPASI 408
             |..||.|.||     |.|:||:  |...:..|:  |:|.|..|...|:..    ..|.|.|.
  Fly   363 -ELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAG----GYFGSEPK-- 420

  Fly   409 EDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHSDP 473
            .|...||.:|:||....:..|.|                             :..:||..|.|..
  Fly   421 PDEVSIICSLVLRSLQFIQFNTH-----------------------------EVAELHKFSSSGR 456

  Fly   474 ITAINL-----PYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRS 533
            ..:|.:     |.|:|.||:|:|.:...|.|.::...:.:.|..|..|...|...|....:.:|.
  Fly   457 EKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQ 521

  Fly   534 HPLKAIYKFECTCAKCTRTDPDQNYLSFH-------RYRCEKPNCRQEFLPDAKVQQNNLRWWLR 591
            ..||.:|.|||:|..|.     .|:..|.       |:||:.||                    .
  Fly   522 ARLKDLYWFECSCDACI-----DNWPKFDDLPRDVIRFRCDAPN--------------------N 561

  Fly   592 CNA--EKP-------ITCTVCHELQHFAWYNEFLGL-IGSSADSSKRQA--LFKAFDDLDKWLVD 644
            |:|  |.|       :.|..|.|:.     |...|| :....:...|.|  |::. .:..|.|..
  Fly   562 CSAVIEVPPSCNDFMVKCVTCGEIT-----NILKGLKVMQDTEMMTRTAKRLYET-GEYPKALAK 620

  Fly   645 HHSLKRIMAEEL-------------VTACFYEIDGGTSLD 671
            ...|.|||.|.|             :..||..:....:||
  Fly   621 FVDLIRIMYEVLAPPFPDFCESQQHLKDCFLNLGNVYTLD 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	9/41 (22%)
		zf-MYND	258..298	CDD:460312	16/40 (40%)
		SET	<359..549	CDD:394802	52/203 (26%)
Smyd4-3	NP_725048.1	TPR repeat	74..103	CDD:276809	10/32 (31%)
		TPR repeat	108..142	CDD:276809	12/34 (35%)
		TPR repeat	150..177	CDD:276809	9/26 (35%)
		SET_SMYD4	235..537	CDD:380934	95/361 (26%)
		zf-MYND	284..323	CDD:460312	16/40 (40%)