DRSC/TRiP Functional Genomics Resources

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Protein Alignment brp and Numa1

DIOPT Version :10

Sequence 1:NP_001400998.1 Gene:brp / 35977 FlyBaseID:FBgn0259246 Length:2243 Species:Drosophila melanogaster
Sequence 2:NP_001390473.1 Gene:Numa1 / 101706 MGIID:2443665 Length:2108 Species:Mus musculus


Alignment Length:1804 Identity:411/1804 - (22%)
Similarity:719/1804 - (39%) Gaps:488/1804 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   771 DYPKLPQEHKRQL-DEFRLEIQRRDQEILAMAAKMKTLEEQHQD----YQR--HIAVLKESLCAK 828
            |..:.||...|:| .:...|...||...|.::..:|.|.|:...    .||  |:|:|.|...|.
Mouse   205 DILQTPQFQMRRLKKQLADERSNRDDLELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAAS 269

  Fly   829 EEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDIKDRKISVLQR 893
            .:.    .:::||:|.    ||..:..:...||:..|          .||......|||||.|..
Mouse   270 SQE----PSELEELRG----KNESLTVRLHETLKQCQ----------NLKTEKSQMDRKISQLSE 316

  Fly   894 KIENLEDLLKEKDNQVDMARARLSAMQAHHS--SSEGA------LTSLEEAIGDK----EK---- 942
            :..:|...::|..|.:...:...:.:...||  |.|.|      ...|..|:.||    ||    
Mouse   317 ENGDLSFKVREFANHLQQLQGAFNDLIEEHSKASQEWAEKQARLENELSTALQDKKCLEEKNEIL 381

  Fly   943 --QMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLE 1005
              :::||.||..|.:.....|:.    ||....::|...:.|..||       .|:..:|:.::|
Mouse   382 QGKLSQLEDQATRLQESPAPEKG----EVLGDALQLDTLKQEAAKL-------ATDNTQLQTRVE 435

  Fly  1006 ASQSELGKSKAELEKATCEMGRSSADWESTKQRIARL--ELEN-----ERLKHDLERSQM----Q 1059
            ..:.|.||.:|:|   ..|..|    :|..||::|.|  :|::     .:.|.:||::..    |
Mouse   436 TLECERGKQEAQL---LAERSR----FEDEKQQLASLIADLQSSVSNLSQAKEELEQASQAQGAQ 493

  Fly  1060 LEEQTTLHKTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQGETEKRFSDAERAREEA 1124
            |..|.| ..|....|.....|||...:|:|.|..|::.:|..|                  :|:|
Mouse   494 LTAQLT-SMTGLNATLQQRDQELASLKEQAKKEQAQMLQTMQE------------------QEQA 539

  Fly  1125 A-ALQEKLEKSQGEVYRLKAKLENAQGEQESLRQE-------LEKAQSGVSRIHADRDRAFSEVE 1181
            | .|::::|:....:...:.:||.|..|||:.||:       :.:|:....|   :||.|..::|
Mouse   540 AQGLRQQVEQLSSSLKLKEQQLEEAAKEQEATRQDHAQQLAIVAEAREASLR---ERDTARQQLE 601

  Fly  1182 KIKEEMERTQATLGKSQLQ-----HEKLQNSLDKAQNEVDHLQDKLDK--ACTENRRLVLEKEKL 1239
            .:::|.:....:| :.|||     .:..|.|:.:||.|...|..|:.:  ||.|...  .|:.::
Mouse   602 TVEKEKDAKLESL-QQQLQAANDARDNAQTSVTQAQQEKAELSQKIGELHACIEASH--QEQRQV 663

  Fly  1240 TYDYDNLQSQLDKALGQAARMQK--ERETLSLDTDRIREKL----EKTQVQLGRIQKERDQFSDE 1298
            ......|::||      .|..||  |||.:..:..:::|:|    |..::..|.:::|:.:.:|.
Mouse   664 QARVTELEAQL------KAEQQKTTEREKVVQEKAQLQEQLRALEESLKITKGSLEEEKRRAADA 722

  Fly  1299 LETLKERSESAQTLLMKAARDREAMQTDLEVLKERYEKS--HAIQQKLQMERDDAVTEVEILKEK 1361
            |:..:.|:...:.........||..|.:||     .||:  ..::.::|...:....|.|.|:.:
Mouse   723 LKEQQCRATEMEAESRSLMEQREREQKELE-----QEKAGRKGLEARIQQLEEAHQAETEALRHE 782

  Fly  1362 LDKALYASQ--------KLIDEKDTSNKEFEKMLEKYDR----AQNEIYRLQSRCDTAEADRARL 1414
            |.:|. |||        :||.|.::..|.||...::..|    .|.::..|:......|.....:
Mouse   783 LAEAT-ASQHRAESECERLIREVESRQKRFEARQQEEARYGAMFQEQLMALKGEKTGQEVQEEAV 846

  Fly  1415 EVEAE------RSGLA---ASKAREDLRKLQDESTRLQEAC-DRAALQLSRAKECEDNARSELEH 1469
            |:.:|      :|.||   ||.|:. ::::|::..|.|:.. |.:|||...|...::.|      
Mouse   847 EIHSEGQPGQQQSQLAQLHASLAKA-IQQVQEKEVRAQKLVDDLSALQEKMAATNKEVA------ 904

  Fly  1470 SRDRFDKLQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKAS---------------ASVEAA 1519
                  .|:|.:.:|..::|....||      |:....|..:||               |:|:|.
Mouse   905 ------CLKTLVLKAGEQQETASLEL------LKEPPRAANRASDQLGEQQGRPFSSTHAAVKAM 957

  Fly  1520 KEEAAHYAVELEKMRDRYEKS---QVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETI 1581
            :.||.....|||::|....||   |.|.|..|:     ||..||.:|                  
Mouse   958 EREAEQMGGELERLRAALIKSQGQQQEERGQQE-----REVARLTQE------------------ 999

  Fly  1582 RGKSQYESESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHI 1646
            ||::|.:..     ::|..|.|:|:: :::.|:|..::....:..:|..|..:|....||.:...
Mouse  1000 RGQAQADLA-----QEKAAKAELEMR-LQNTLNEQRVEFAALQEALAHALTEKEGTDQELAKLRG 1058

  Fly  1647 EREKARDKHEKLLKEVDRLRLQQSSVSPGDPV------RASTSSSSALSAGERQ----EIDRLRD 1701
            :....|.:.::|.:.:::|::|........|.      .||...:.:.:||:..    |:..||.
Mouse  1059 QEAAQRTELKELQQTLEQLKIQLVKKEKEHPAGGASGEDASGPGTQSETAGKTDAPGPELQALRA 1123

  Fly  1702 RLEKALQSRDATELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLEKAEAER 1766
            .:.|..|.....:.:...|...|:..:...|:|.:..|:.:.:.|....|||  |::...|.|:|
Mouse  1124 EISKLEQQCQQQQQQVEGLTHSLKSERACRAEQDKALETLQGQLEEKARELG--HNQAASASAQR 1186

  Fly  1767 E--ALRQANRSGGAGAAPHPQLEKH------------------VQKLESDVKQL---AMERE--- 1805
            |  |||       |.|..|.:.|:.                  :..||.:|..|   .:|:|   
Mouse  1187 ELQALR-------AKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGES 1244

  Fly  1806 -----QLVLQLEKSQEI-----LMNFQKELQNAEA---------ELQKTREENRKLR----NGHQ 1847
                 .:|.:.||||::     |:..:....:|.|         |:|..|||..|.|    |..|
Mouse  1245 KELKRLVVAESEKSQKLEERLRLLQVETASNSARAAERSSALREEVQSLREEVEKQRVVSENSRQ 1309

  Fly  1848 VPPVAAPPAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQ---------------------Q 1891
            .....|..|       :.:.:|::..|:|..:.|:||.|...:                     |
Mouse  1310 ELASQAERA-------EELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQ 1367

  Fly  1892 AQAAAAAGASREEIEQWR-------------------------KVIEQEKS----RADMADKAAQ 1927
            |:.|||....|||:||.:                         |::|||::    ||:.|..|.|
Mouse  1368 AEQAAAEKRFREELEQSKQAAGGLQAELMRAQRELGELGSLRQKIVEQERAAQQLRAEKASYAEQ 1432

  Fly  1928 -----EMH-----------KRIQLMDQHIKDQHAQ-MQKMQQQMQQQQQAAQQAVQQAAQQQQSA 1975
                 :.|           :|..|..|.::.:..| .:|..|::...:..|:..:.:..|:.||.
Mouse  1433 LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQST 1497

  Fly  1976 AGAGGADPKELE----KVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQ------- 2029
            :       :|||    |..|.......||.|||::.:.|..::|:.::..:||.||::       
Mouse  1498 S-------RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLT 1555

  Fly  2030 ---------------------TAQQQVQQLQQQVQQLQQQMQQLQQA----------ASAGAGAT 2063
                                 .:||:||:||.|:.:||.|:.|.:||          |.....|.
Mouse  1556 EHDQASKVQQQKLKAFQAQRGESQQEVQRLQTQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK 1620

  Fly  2064 DVQRQQLEQQQKQLEEVRKQIDNQAKATEGERKIIDEQRKQIDAKRKDIEEK-----------EK 2117
            ..|.|:|::|.:.|||::|  :|:...:|.||  :..:.:|...|.|:.|:.           |.
Mouse  1621 KQQNQKLQEQLQDLEELQK--ENKELRSEAER--LGRELQQAGLKTKEAEQTCRHLTAQVRSLEA 1681

  Fly  2118 KMAEFDVQLR------------KRKE---------QMDQLEKSLQ-------------TQGGGAA 2148
            ::|..|.|||            |.:|         .:|.|:.||:             ||..|.:
Mouse  1682 QVAHADQQLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLEEGTPCSVASKLPRTQPDGTS 1746

  Fly  2149 AAGE----LNKKLMDT----------------QRQLEACVKELQNT-KEEHKKAATETERLLQLV 2192
            ..||    ::::|...                |..||..:..|.:. .:..:|..:...|..|::
Mouse  1747 VPGEPASPISQRLPPKVESLESLYFTPTPARGQAPLETSLDSLGDAFPDSGRKTRSARRRTTQII 1811

  Fly  2193 QMSQ------EEQNAKEKTIMDLQQALKIAQAKVKQAQTQQQQQQDAGP 2235
            .::.      ||.::...:....|.| ..:||.::...:.|...:...|
Mouse  1812 NITMTKKLELEEPDSANSSFYSTQSA-PASQANLRATSSTQSLARLGSP 1859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brpNP_001400998.1 Cast 160..>313 CDD:431111
Cast <780..1186 CDD:431111 111/449 (25%)
SMC_prok_B 870..1664 CDD:274008 209/885 (24%)
SMC_prok_B 1427..2214 CDD:274008 227/1045 (22%)
Numa1NP_001390473.1 Head (Globular). /evidence=ECO:0000250|UniProtKB:Q14980 1..210 1/4 (25%)
HkD_NuMA 6..151 CDD:411795
Smc <213..>814 CDD:440809 166/673 (25%)
SMC_prok_B 554..1323 CDD:274008 194/850 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 617..636 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..759 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 921..1000 26/107 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1081..1143 10/61 (16%)
Smc <1117..>1652 CDD:440809 131/561 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1173..1223 15/58 (26%)
PRK06975 <1566..1754 CDD:235899 48/191 (25%)
Membrane-binding domain 1. /evidence=ECO:0000250|UniProtKB:Q14980 1695..1872 27/166 (16%)
Tail (Globular). /evidence=ECO:0000250|UniProtKB:Q14980 1696..2108 27/165 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1732..1757 5/24 (21%)
Tankyrase-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980 1738..1744 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1774..1809 6/34 (18%)
4.1-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980 1784..1806 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1821..1897 8/40 (20%)
NuMA_LGNBD 1866..1924 CDD:412093
Tubulin-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980 1878..1981
GPSM2-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980 1888..1922
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1951..2108
Membrane-binding domain 2. /evidence=ECO:0000250|UniProtKB:Q14980 1977..2056
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q14980 1980..1985
Blue background indicates that the domain is not in the aligned region.

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