Protein Alignment Myd88 and MYD88

DIOPT Version :10

• Sequence 1: NP_610479.1
• Gene: Myd88 / 35956
• FlyBaseID: FBgn0033402
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001166038.2
• Gene: MYD88 / 4615
• HGNCID: 7562
• Length: 304
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 83/332 - (25%)
• Similarity: 144/332 - (43%)
• Gaps: 57/332 - (17%)

  Fly    66 GSGSGTGTGLGHFNETPLSALGIETRTQLSRMLNRKKVLRSEEGYQRDWRGISELAKQKGFVD-- 128
            |.|:|:...:...:..||:||.:..|.:||..||.:..:.:      ||   :.||::..|..
Human     5 GPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAA------DW---TALAEEMDFEYLE 60

  Fly   129 ----ENANNPMDLVLISWSQRSPQTAKVGHLEHFLGIIDRWDVCDDIQENLAKDTQRFIMKQEQR 189
                |...:|...:|.:|..|  ..|.||.|...|..:.|.||..::..::.:|.|::|:||:|.
Human    61 IRQLETQADPTGRLLDAWQGR--PGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQE 123

  Fly   190 ------QTALVEACPPPPSDCFETNNNYSSSNNITVGQSVQILSDEDQRCVQMGQPLPRYNACVL 248
                  |.|.|::..|..::.                ..:..|.|      .:|....|::|.:.
Human   124 EAEKPLQVAAVDSSVPRTAEL----------------AGITTLDD------PLGHMPERFDAFIC 166

  Fly   249 YAEADIDHATEIMNNLESERYNLRLFLRHRDMLMG-----VPFEHVQLSHFMATR----CNHLIV 304
            |..:||....|::..||...|.|:|.:..||:|.|     :..|.::..  :|.|    |..::|
Human   167 YCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKR--LARRPRGGCRRMVV 229

  Fly   305 VLTEEFLRSPENTYLVNFTQKIQIENHTRKIIPILYKT-DMHIPQTLGIYTHIKYAGDSKLFNFW 368
            |:::::|:|.|..:...|...:....|.:::|||.||. ....|..|...|...|........||
Human   230 VVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFW 294

  Fly   369 DKLARSL 375
            .:||::|
Human   295 TRLAKAL 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_610479.1	DD	90..172	CDD:472698	23/87 (26%)
		SEFIR	242..375	CDD:474043	39/142 (27%)
MYD88	NP_001166038.2	Death_MyD88	29..106	CDD:260026	23/87 (26%)
		TIR	160..304	CDD:214587	40/144 (28%)