Protein Alignment Myd88 and Myd88

DIOPT Version :10

• Sequence 1: NP_610479.1
• Gene: Myd88 / 35956
• FlyBaseID: FBgn0033402
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_034981.1
• Gene: Myd88 / 17874
• MGIID: 108005
• Length: 296
• Species: Mus musculus
• Alignment Length: 324
• Identity: 86/324 - (26%)
• Similarity: 142/324 - (43%)
• Gaps: 53/324 - (16%)

  Fly    66 GSGSGTGTGLGHFN-ETPLSALGIETRTQLSRMLNRKKVLRSEEGYQRDWRGISELAKQKGFVD- 128
            ||||     |..|. ..||.||.:..|.:||..||.:..:.:      ||   :.||::.||..
Mouse     9 GSGS-----LDSFMFSIPLVALNVGVRRRLSLFLNPRTPVAA------DW---TLLAEEMGFEYL 59

  Fly   129 -----ENANNPMDLVLISWSQRSPQTAKVGHLEHFLGIIDRWDVCDDIQENLAKDTQRFIMKQEQ 188
                 |...:|...:|.:|..||  .|.||.|...|.::||.|:..:::..:.:|.|:::.||:.
Mouse    60 EIRELETRPDPTRSLLDAWQGRS--GASVGRLLELLALLDREDILKELKSRIEEDCQKYLGKQQN 122

  Fly   189 R------QTALVEACPPPPSDCFETNNNYSSSNNITVGQSVQILSDEDQRCVQMGQPLPRYNACV 247
            :      |.|.||:..|...:               :| .:..|.|      .:||....::|.:
Mouse   123 QESEKPLQVARVESSVPQTKE---------------LG-GITTLDD------PLGQTPELFDAFI 165

  Fly   248 LYAEADIDHATEIMNNLESERYNLRLFLRHRDMLMGVPFEHVQLSHFMATRCNHLIVVLTEEFLR 312
            .|...||:...|::..||...|.|:|.:..||:|.|.....: .|..:..||..::||:::::|:
Mouse   166 CYCPNDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSI-ASELIEKRCRRMVVVVSDDYLQ 229

  Fly   313 SPENTYLVNFTQKIQIENHTRKIIPILYKT-DMHIPQTLGIYTHIKYAGDSKLFNFWDKLARSL 375
            |.|..:...|...:......:::|||.||. ....|..|...|...|........||.:||::|
Mouse   230 SKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDYTNPCTKSWFWTRLAKAL 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_610479.1	DD	90..172	CDD:472698	25/87 (29%)
		SEFIR	242..375	CDD:474043	36/133 (27%)
Myd88	NP_034981.1	Death_MyD88	29..106	CDD:260026	23/82 (28%)
		Intermediate domain	110..155		9/50 (18%)
		TIR	161..296	CDD:214587	35/135 (26%)