DRSC/TRiP Functional Genomics Resources

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Protein Alignment hig and SVEP1

DIOPT Version :10

Sequence 1:NP_724773.1 Gene:hig / 35949 FlyBaseID:FBgn0010114 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:634 Identity:161/634 - (25%)
Similarity:238/634 - (37%) Gaps:153/634 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 DDPEFDEEEEEDEEVDIL------------QQFTEVSEIRFPGEIGPMGDRRLCKIRCVKGKWVG 487
            ||..:||:|.....||..            .::|...||.:....|.:.:....::....|.|.|
Human  2817 DDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881

  Fly   488 ------PL-CATNEEDDNG-----------NVKFQPLYKSCHVNRI----PSHLLLSYRNISV-T 529
                  |: |||..:..||           .|.|.     ||...|    |.....|..|... .
Human  2882 ATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFH-----CHEGYILHGAPKLTCQSDGNWDAEI 2941

  Fly   530 PI--PPNRGWRKTRLSKSTLLSNTEINVGWDLPHGHSLQARCQELGIYKLLGESRVLC-SNGLWA 591
            |:  |.|.|..:.       |::...| |:...||..:|.:|  ...|||.|.|...| |||.|:
Human  2942 PLCKPVNCGPPED-------LAHGFPN-GFSFIHGGHIQYQC--FPGYKLHGNSSRRCLSNGSWS 2996

  Fly   592 PRMPSCVP---TTVLTNYSE------DSAPSIRIKIFNGSHSFEPSGVMAVP-----------PH 636
            ...|||:|   :|.:..|..      |...:.||:.|.|   |:..|:..:.           ||
Human  2997 GSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKG---FKLLGLSEITCEADGQWSSGFPH 3058

  Fly   637 STVLMDC---------MYPRVRGTPEWSWTSWYMQYS--TG----------------WS---PAQ 671
                  |         |.|....:...||....:.||  :|                ||   |..
Human  3059 ------CEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVC 3117

  Fly   672 E----------------------EKAVRYRLSIKNIENNDSGTFTCTSP-RGLTNSIAVVVATST 713
            |                      |..|:.|.......:.|:.||||... |.....|:  .:...
Human  3118 EPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERIS--CSPKK 3180

  Fly   714 CPQLTEPLAPLKLRLEGNKLGQRAHYECPEGFRLDGAWNATCLASGNWSSP--TPTCHAIQCPRL 776
            || |.|.:..:.:..:...:.::....|.||:..:|...:.|...|.|..|  ..:|..:.|.:.
Human  3181 CP-LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKP 3244

  Fly   777 ELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNG 841
            |..: |..::....:.....:::|:.|::|.|..:..|:.:..|||.|..||..:|..|:..|||
Human  3245 ESPE-HGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG 3308

  Fly   842 RIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCK-SQCPYP-GDPPNGL 904
            :   ..:..|  |.|..|.:|||.|:||.|.|...|||||.|||..|.|| :.||.| ..|.|.|
Human  3309 K---ADIENR--TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENAL 3368

  Fly   905 IAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCK 953
            ::..:|..|..  :|::||.||:....|   ...|.||..|:....||:
Human  3369 LSEKEFYVDQN--VSIKCREGFLLQGHG---IITCNPDETWTQTSAKCE 3412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
higNP_724773.1 Ig_3 612..696 CDD:464046 27/146 (18%)
PHA02927 705..952 CDD:222943 74/250 (30%)
SVEP1NP_699197.3 VWA 83..258 CDD:459670
Ephrin_rec_like 310..360 CDD:429604
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
HYR 560..642 CDD:460572
HYR 644..722 CDD:460572
O-glycosylated at one site 887..894
Ephrin_rec_like 1005..1052 CDD:429604
Ephrin_rec_like 1059..1106 CDD:429604
Ephrin_rec_like 1113..1160 CDD:429604
EGF_CA 1196..1229 CDD:238011
EGF_CA 1231..1267 CDD:238011
EGF_CA 1269..1305 CDD:238011
EGF_CA 1308..1342 CDD:238011
EGF_CA 1345..1381 CDD:238011
EGF_CA 1383..1419 CDD:238011
LamG 1424..1622 CDD:473984
Sushi 1628..1685 CDD:459664
CCP 1690..1743 CDD:153056
EGF_CA 1745..1783 CDD:214542
PHA02927 1789..2017 CDD:222943
PHA02817 1958..>2079 CDD:165167
PHA02927 2094..2319 CDD:222943
PHA02831 2280..>2436 CDD:165176
PHA02927 2401..2609 CDD:222943
Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0 2639..2646
CCP <2670..2713 CDD:153056
PHA02639 2714..>2887 CDD:165022 14/69 (20%)
PHA02639 2833..>3003 CDD:165022 44/184 (24%)
Cell attachment site. /evidence=ECO:0000255 2845..2847 0/1 (0%)
PHA02927 3015..3229 CDD:222943 42/225 (19%)
PHA02927 3195..3411 CDD:222943 69/226 (31%)
CCP 3416..3469 CDD:153056
Blue background indicates that the domain is not in the aligned region.

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