Protein Alignment hig and svep1

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001429572.1
• Gene: svep1 / 567357
• ZFINID: ZDB-GENE-110726-1
• Length: 3615
• Species: Danio rerio
• Alignment Length: 777
• Identity: 171/777 - (22%)
• Similarity: 262/777 - (33%)
• Gaps: 238/777 - (30%)

  Fly   298 PKEDELELDHPETAAAHHRRRG---DSHAAELDQRD----RSPRWRRRRSTEFKGDLGQLPPESG 355
            |:...::...|.....|...||   ||...||...:    ...|..|...::...|...:..:..
Zfish  2319 PRCSPVQCPEPPLEENHLVLRGLDSDSGTVELSCEEGYVLHGARTLRCTPSQEWNDSFPVCKQVF 2383

  Fly   356 IGPEPEPLADQDLKDLQQYGNQSSSARVALLWQRVKRKSG----KTTGALSRPK----------- 405
            .||.|| :|..|..|.|.|  ..|....:.:.....||.|    :..|..|:|.
Zfish  2384 CGPPPE-VAFGDPSDTQSY--FGSVVTYSCMDGFTLRKEGSVHCQANGNWSKPYPQCIPVECPHP 2445

  Fly   406 ---GGGDSSSKTTSRKDKGIYDEEAGYTPIHPDDPEFDEEEEEDEEVDILQQFTEVSEIRFPGEI 467
               ..|....:........:|..:|||                    |||...|
Zfish  2446 EDIPNGIVDVQGLMYLSTAVYSCKAGY--------------------DILGNST----------- 2479

  Fly   468 GPMGDRRLCKIRC-VKGKWVGPL-------CATNEEDDNGNVKFQPLYKSCHVNRIPSHLLLSYR 524
                      :.| ..|:|:|.:       ||..:|..||:|::..|..|..:...
Zfish  2480 ----------VLCGQSGQWIGGIPVCHPVKCAAPKEIPNGSVRYSKLQFSQSITYF--------- 2525

  Fly   525 NISVTPIPPNRGWRKTRLSKSTLLSNTEINVGWD----------------LPHGHSLQARCQELG 573
                    ..||:|.......|.|.|.:    ||                :.:|. ::.|.::.|
Zfish  2526 --------CQRGYRIQGPETLTCLENGQ----WDQEAPTCVPIYCSPPKPIDNGF-VEGRDRKFG 2577

  Fly   574 I---------YKLLGESRVLCSNGLWAPRMPSCV-------PTTVLTNYSE--------DSAPSI 614
            :         :.|:|.:.:.|.:..|:...|.||       |.....:||:        |...|.
Zfish  2578 VTIFYSCFPGFLLVGNNHLTCEDHGWSSSEPKCVLADCGLPPHIDFGDYSKVQELSAEYDMVTSQ 2642

  Fly   615 RIKIFNGSHSFEPSGVMAVPPHS------TVLMDCMYPRVRGTPEWSWT---------------- 657
            ::.:.|   ||....::....||      .:::.|   |..||  |:.|
Zfish  2643 QLPVDN---SFLHGSLVKYHCHSGYEINGAIMLMC---REDGT--WNGTAPMCTPAQCEAPPSPE 2699

  Fly   658 --SWYMQYSTGWSPAQEEKAVRYRLSIKNIENNDSG-----------TFTCTSPRGLTNSIAVVV 709
              |..:..|...|.|:...|..|.|:.:.|....||           ..:|.:|.|:.|
Zfish  2700 NGSVMVTDSALGSLAEYSCAEGYELNGQTIRQCISGQQWSDDAPRCLPISCGNPGGIAN------ 2758

  Fly   710 ATSTCPQLTEPLAPLKLRLEGNKLG------QRAHYECPEGFRLDGAWNATCLASGNWSSPTPTC 768
                                |..:|      :..||||..||.|:|....||...|.|.:..|.|
Zfish  2759 --------------------GEVIGKSFHFKELIHYECHSGFVLEGVETRTCQVDGKWDNKAPLC 2803

  Fly   769 HAIQCPRLELDDPHLS---LIELNTSAWG-RAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKV 829
            ..:.|.|     |.:|   |:..:...:| |.:|.|..||.|.|...:.|..:|.|:...|:|..
Zfish  2804 KEVSCGR-----PVVSKDVLVRGDDHTFGKRLLFSCNLGFILLGAPTIVCLANGSWNEVPPKCLP 2863

  Fly   830 IQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCK-SQ 893
            ..|..|.:..|||:.||...     ...:|.::|:.|:.|.|..::||..:|.|...||.|. ..
Zfish  2864 ANCGQPPSIENGRVTGTDYG-----YNGMVRYACDIGYVLTGNPTLICRADGLWDDPPPRCDIIT 2923

  Fly   894 CPYPGDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYE--GPPERPKCQPDGRWSGPMPKCK 953
            |..|.|..:|.:....||:|  |.:...|.||    ||  |.|.. :|..:|.|.|.:|:|:
Zfish  2924 CDPPEDISHGYLNGSSFNFD--DIVEYICFPG----YEVVGSPIL-RCAAEGVWLGQVPECR 2978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	22/118 (19%)
		PHA02927	705..952	CDD:222943	73/259 (28%)
svep1	NP_001429572.1	None