Protein Alignment hig and Hasp

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Alignment Length: 1087
• Identity: 259/1087 - (23%)
• Similarity: 397/1087 - (36%)
• Gaps: 314/1087 - (28%)

  Fly   118 LHVGDAAASLVGDD----DLGDEDEDHHGDPEDKRLNANRKQGKRRRAGSGR------------- 165
            |.||...|:.||..    ||.......|     .||..||   :|||:...|
  Fly   626 LEVGPPGATCVGGKWRPLDLPQCLLGQH-----PRLRWNR---RRRRSLQIRQLRSMYLLQRQRQ 682

  Fly   166 --RRRIENEN-----GQTGRGRGSRYKRHAILHDTEA--SPETDRWAGSKLAAEGDVYYVHIAD- 220
              |:.|:|:|     ....:....|.||.|..|....  :.:.|| |.||       ||..|.:
  Fly   683 LQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDR-AYSK-------YYQKIKER 739

  Fly   221 ----ILKSREPNRELKSKLHKLKMKARLNKCL--AEGGKEKCTRLLKKKPKKKVVEKEQTLKKEK 279
                :.|....:| :..:||......|:...|  .:||                   :.|::.:.
  Fly   740 YQRYVRKMLGRDR-IYQRLHSQDAVGRVGNNLNTHDGG-------------------QVTMRGKS 784

  Fly   280 KFPKEEQSKEKVPENG-----------------------------QTPKEDELELDHPETAA-AH 314
            .|.:.|.....:...|                             :||||:.|....|..|: :.
  Fly   785 NFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSL 849

  Fly   315 HRRRGDSHAAELDQRDRSPRWRRRRSTEFKGDLGQLPPESGIGPEPEPLADQDLKDLQQYGNQSS 379
            |.....|:..:|  :.:..|.|||||:    .:||.||.||   ...|.|:.|:.|..:.|....
  Fly   850 HLNATRSYIEQL--KSQIVRRRRRRSS----SIGQSPPPSG---ATIPDAEVDISDGGEAGKGGG 905

  Fly   380 SARV-----ALLWQRVKR----KSGKTTGALS---------------RPKGGGDSSSKTTSRKDK 420
            ..|:     .|.|.....    :.||..|..:               ..||     ...|:|..:
  Fly   906 GKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKG-----ENATARCIR 965

  Fly   421 GIYD----------------EEAGYTPIHP------DDPEFD-----EEEEEDEEVDI------- 451
            ||:.                |...|..:.|      |.|...     ||.:.:|.:.:
  Fly   966 GIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFN 1030

  Fly   452 ---------------LQQFTEVSEI-----RFPGEIGPMGDRR------------LCKI------ 478
                           :..|:|.:.:     ..||.|...|.|.            .|::
  Fly  1031 IQGSAQLRCAHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANP 1095

  Fly   479 ---RCVKGKWVGPL--CAT--------------------------NEED--DNGNVKFQPLYKSC 510
               .|.||....|.  |.:                          |:.|  |||..:...: |.|
  Fly  1096 IEMSCHKGILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDM-KMC 1159

  Fly   511 HVNRIPSHLLLSYRN---------------ISVTPIPPNRGWRKT-RL---------------SK 544
            ....:....|: |:|               |....||...|.|:| |:               :.
  Fly  1160 GPPMLTDGALV-YKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENG 1223

  Fly   545 STLLSNTEINV------------GWDLPHGHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSC 597
            :.:..|.|.||            ..|.|.|.::.:||.::|.:..:|.....|.:..|....|.|
  Fly  1224 TCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVC 1288

  Fly   598 VPTTVLTNYSEDSAPSIRIKIFNGSHSFEPSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQ 662
            .......:|:.:.||:|..:..||..:....|.:.|.|.:|:.|:|::.|..|.|:|:.:..:..
  Fly  1289 SGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKN 1353

  Fly   663 YSTGWSPAQEE---KAVRYRLSIKNIENNDSGTFTCTSPRGLTNSIAVVVATSTCPQLTEPLAPL 724
            |:.||....:|   ..:.|||||.:..::|||.::|.:|....:::.|||....||::     |:
  Fly  1354 YTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEI-----PM 1413

  Fly   725 KLRLEGN----KLGQRAHYECPEGFRLDGAWNATCLASGNWSSPTPTCHAIQCPRLEL------D 779
            :..|..|    ||..||...|..|..|.||....||.|||||:|.|.|.:::|..:.|      .
  Fly  1414 RRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNAS 1478

  Fly   780 DPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNGRIG 844
            .|.:|:  |:....|||.|.|..|:.|.|||:..|.|:|.||.|:|.|..:||..|.||.||...
  Fly  1479 SPRVSV--LSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQ 1541

  Fly   845 GTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKSQCPYPGDPPNGLIAPLK 909
            |::    ....|.:|.|:||..:.:.|:..|.|.:|.:||...|.|...|.|||...:|.::.:|
  Fly  1542 GSA----PYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGRMSSVK 1602

  Fly   910 FNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCKSYE 956
            |.|..|:.::..|..|.  ...| .:..||..:|:||..:|.|.:.|
  Fly  1603 FYYAIGESITFTCDAGL--DLRG-SKVLKCLKNGKWSSAIPTCVTNE 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	26/86 (30%)
		PHA02927	705..952	CDD:222943	89/256 (35%)
Hasp	NP_001137842.2	CCP	121..175	CDD:153056
		PHA02927	182..421	CDD:222943
		PHA02927	<497..>654	CDD:222943	9/32 (28%)
		PHA02927	<946..1111	CDD:222943	26/169 (15%)
		CCP	1408..1462	CDD:153056	23/58 (40%)
		PHA02927	<1488..1643	CDD:222943	57/161 (35%)