Protein Alignment hig and Cr2

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_008768069.1
• Gene: Cr2 / 289395
• RGDID: 1310065
• Length: 1406
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 136/577 - (23%)
• Similarity: 214/577 - (37%)
• Gaps: 154/577 - (26%)

  Fly   478 IRCV-KGKW--VGPLC-----------------------ATNEEDDNGNVKFQPLYKSCHVNRIP 516
            |.|. :|||  :.|.|                       |.|...|.|....:..|:.|. ..||
  Rat   829 IHCTSEGKWTPIPPQCKVAECKPVGPHVFERPQNHFIRPAINSSCDEGFQISESAYQLCQ-GTIP 892

  Fly   517 SHLLLSYRNISVTPIPP-----NRGWRKTRLSKSTLLSNTEINVGWDLPHGHSLQARC---QELG 573
            ..:.:........|.||     ...||.:.                |:|:|..:...|   .|.|
  Rat   893 WFIEIRLCKEITCPPPPIILNGTHTWRSSE----------------DVPYGTVITYMCYPGSEEG 941

  Fly   574 I-YKLLGESRVLCSN-----GLWAPRMPSC---VPTTVLT--------NYSEDSAPSIRIKIFNG 621
            : :||:||..:.|::     |.|:...|.|   :|....|        ..:::.||    ..:|.
  Rat   942 VKFKLIGEQTIHCTSDSRGRGSWSSPAPLCKLSLPAVQCTEVHVENGVKLTDNKAP----YFYNN 1002

  Fly   622 SHSFEPSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQYSTGWSPAQEEKAVR--------- 677
            |.:|:..       ...:|:.....|.:....|...:.:.: ..|..|.::...:.
  Rat  1003 SVTFKCR-------DGYILIGSSQIRCKANNTWDPEAPHCK-KEGCEPMRKLPGISDHSLIKLVN 1059

  Fly   678 ------YRL---SIKNIENNDSGTF----------TCTSPRGLTNSIAVVVATSTCPQLTEPLAP 723
                  |:|   :.:..:|.::||:          .|..|..:.|.       |....:.|..
  Rat  1060 RTCQNGYQLTGYTYEKCQNAENGTWFQKIAVCTVILCPPPPTIANG-------SHTGMMAEHF-- 1115

  Fly   724 LKLRLEGNKLGQRAHYECPEGFRLDGAWNATCLASGNWSSPTPTC----HAIQCPRLELDDPHLS 784
                |.||::.    |||.:||.|.|..:..|...|:||.|.|.|    ....||     ||.:.
  Rat  1116 ----LYGNEVS----YECDKGFYLLGEKSLQCKGHGSWSGPPPQCLQSSPLTHCP-----DPEVK 1167

  Fly   785 L-IELNT--SAWGR---AVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRC---KVIQCVMPVAPLN 840
            . .:||.  ||:..   ....|..||.:.|...:.|..:..|...||.|   ..:.|..|....|
  Rat  1168 YGYKLNKTHSAYSHNDIIHVVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRTASLGCQSPPTIPN 1232

  Fly   841 GRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKS-QCPYPGDPPNGL 904
            |...|.:::  |.:.|..|.:||..|:.:.||:.:|||..|.|||..|:||. .|.:|.| .||:
  Rat  1233 GNHTGGTIA--RFSPGMSVMYSCYQGYLMAGEARLICTHEGTWSHPAPYCKEVNCSFPED-TNGI 1294

  Fly   905 ---IAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCKSYEEV 958
               ..|.| .|..|..::::|..|:  |.||.|: .:||.:.:|:.|:..||:...|
  Rat  1295 QKGFQPGK-TYRFGTTVTLECEDGY--SLEGSPQ-SQCQDENQWNPPLAICKNRSTV 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	14/111 (13%)
		PHA02927	705..952	CDD:222943	78/263 (30%)
Cr2	XP_008768069.1	PHA02927	10..274	CDD:222943
		PHA02927	295..524	CDD:222943
		PHA02927	554..784	CDD:222943
		PHA02927	746..1035	CDD:222943	45/233 (19%)
		PHA02927	992..1218	CDD:222943	54/259 (21%)
		PHA02639	1088..>1341	CDD:165022	81/281 (29%)