Protein Alignment hig and CSMD3

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_937756.1
• Gene: CSMD3 / 114788
• HGNCID: 19291
• Length: 3707
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 162/664 - (24%)
• Similarity: 237/664 - (35%)
• Gaps: 195/664 - (29%)

  Fly   439 FDEEEEEDEEVDILQQFTEVSEIRFPGEIGPMGDRRLCKIRCVKG-----KWVGPLCATNEEDDN 498
            |.|..:.::|.|:||.: :...|:.|..|...||..........|     :|         ..|:
Human  2499 FVEFFQTEKEFDVLQVY-DGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQW---------SADH 2553

  Fly   499 GNVK--FQPLYKS--CHVNRIPSH-LLLSYRN---ISVTPIPPNRGWRKTRLSKSTLLSNTEINV 555
            ||.|  |:..|.:  |.....|.| .::|...   .||.....:||:|....|.:....::....
Human  2554 GNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYH 2618

  Fly   556 GWDLPHGHSLQARCQEL--GIYK------------LLGESRV------------------LC-SN 587
            .||.|     ...||.:  ||.|            |:| :||                  :| |:
Human  2619 AWDAP-----VPACQAISCGIPKAPTNGGILTTDYLVG-TRVTYFCNDGYRLSSKELTTAVCQSD 2677

  Fly   588 GLWA--PRMPSCVPTTVLTNYSEDSAPSI--------RIKIFNGSH---------SFEPSGVMAV 633
            |.|:  .:.|.||..|         .|||        |.:|.||||         |.:| |...:
Human  2678 GTWSNHNKTPRCVVVT---------CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDP-GYHGL 2732

  Fly   634 PPHSTVLMDCMYPRVRGTPEWSWTSW--YMQ---------------------------------- 662
            .|.|   ::|:   ..||  |||.:.  |.|
Human  2733 GPAS---IECL---PNGT--WSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGF 2789

  Fly   663 ----------YSTG-WSPAQ----------EEKAVRYRLSIKNIENNDSGTFTCTSPRGLTNSIA 706
                      .|:| ||.::          .|..|..::..:|....|:..:.|.....|..|
Human  2790 MLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGS-- 2852

  Fly   707 VVVATSTCPQ---------------LTEPLAPLKLRLEGN--KLGQRAHYECPEGFRLDGAWNAT 754
               :...|.|               ...|.:|:..|..||  .......:.|..|:.:.|...|.
Human  2853 ---SVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQ 2914

  Fly   755 CLASGNWSSPTPTCHAIQC--PRLELDDPHLSLIELNTSAWGRAVF-KCQWGFKLTGPAQLDCEP 816
            |.|:..||.|.|.|..:.|  |.:..:....|.||.....:|..|| .|..|:.|.|.:.|.|:|
Human  2915 CQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP 2979

  Fly   817 SGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENG 881
            :|.|..|:|.|.:|.|..|..|.|..:.|     .:.|.|:.|.:||....||:|:||..|..||
Human  2980 NGQWDKPLPECIMIDCGHPGVPPNAVLSG-----EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG 3039

  Fly   882 QWSHSPPFCKSQ----CPYPGDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPD 942
            .||.|.|.|...    |..||.|.:|  :..:.|:.....:...|..|::  ..|..|| .|..:
Human  3040 HWSGSQPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYI--LHGSEER-TCLAN 3099

  Fly   943 GRWSGPMPKCKSYE 956
            |.|:|..|:||:.:
Human  3100 GSWTGRQPECKAVQ 3113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	30/157 (19%)
		PHA02927	705..952	CDD:222943	78/270 (29%)
CSMD3	NP_937756.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		CUB	65..171	CDD:238001
		CCP	178..236	CDD:153056
		CUB	257..343	CDD:238001
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..435
		CCP	486..544	CDD:153056
		CUB	548..656	CDD:238001
		CCP	664..718	CDD:153056
		CUB	721..828	CDD:238001
		CCP	834..891	CDD:153056
		CUB	895..1002	CDD:238001
		CCP	1010..1063	CDD:214478
		CUB	1067..1175	CDD:238001
		CCP	1182..1238	CDD:153056
		CUB	1241..1348	CDD:238001
		CCP	1354..1411	CDD:153056
		CUB	1414..1522	CDD:238001
		CCP	1528..1585	CDD:153056
		CUB	1588..1695	CDD:238001
		CCP	1701..1758	CDD:214478
		CUB	1762..1869	CDD:238001
		CCP	1878..1936	CDD:153056
		CUB	1939..2046	CDD:238001
		CCP	2052..2107	CDD:153056
		CUB	2111..2218	CDD:238001
		CCP	2224..2280	CDD:153056
		CUB	2283..2389	CDD:238001
		CCP	2395..2453	CDD:153056
		CUB	2460..2566	CDD:238001	19/76 (25%)
		CCP	2569..2628	CDD:153056	13/63 (21%)
		PHA02927	2627..2871	CDD:222943	52/267 (19%)
		PHA02927	2756..2991	CDD:222943	48/239 (20%)
		PHA02927	2928..3168	CDD:222943	63/196 (32%)
		PHA02927	3168..3407	CDD:222943
		CCP	3411..3467	CDD:153056