DRSC/TRiP Functional Genomics Resources

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Protein Alignment hig and CSMD2

DIOPT Version :10

Sequence 1:NP_724773.1 Gene:hig / 35949 FlyBaseID:FBgn0010114 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_001268885.1 Gene:CSMD2 / 114784 HGNCID:19290 Length:3631 Species:Homo sapiens


Alignment Length:723 Identity:166/723 - (22%)
Similarity:255/723 - (35%) Gaps:230/723 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 DSSSKTTSRKDKGIYDEE---AGYTPIHPD-----DPEFDEEEEEDEEVDILQQFTEVSEIRFPG 465
            ||:....|:...|.|.:.   :....:.||     ..|:...|::.:|.:|..            
Human  2361 DSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFD------------ 2413

  Fly   466 EIGPMGDRRLCKIRCVKGKWVGPLCATN---------EEDDNGNVK-FQPLYKS--CHVNRIPSH 518
              ||.|...|  ::.:.|.:..||..|:         ..|...|.| |:..|.:  |.:.|.|.|
Human  2414 --GPSGQSPL--LKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLH 2474

  Fly   519 LLLSYRNISVTPIPP--------NRGWRK--------TR-----------------LS------- 543
            ..:    :..|...|        |.|:|.        ||                 ||       
Human  2475 GFI----LGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAP 2535

  Fly   544 KSTLLSNTEINVG----WDLPHGHSLQARCQELGIYKLLGESRVLC-SNGLWAPR--MPSCVPTT 601
            |:.::...|..||    :....|:.|||.          .|:...| ..|||:.|  .|.|||.|
Human  2536 KNGMVFGKEYTVGTKAMYSCSEGYHLQAG----------AEATAECLDTGLWSNRNVPPQCVPVT 2590

  Fly   602 VLTNYSEDSAPSIRIK------IFNGSHSFEPS-------------------------------- 628
            .      ....||.::      ||...:.|:..                                
Human  2591 C------PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTP 2649

  Fly   629 -------GVMAVPPH-----------STVLMDC------MYPRVR---GTPEWSWTS-------- 658
                   |.:.:||:           :|.:..|      :..|||   ....||.:.        
Human  2650 TCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQT 2714

  Fly   659 ------WYMQYSTGWSPA--------QEEKAVRYRLSIKNIENNDSGTFTCTSP-RGLTNSIAVV 708
                  :.:.:....||:        ..|..|...::.:|.....|..:.|.:. |.:..|:.:.
Human  2715 KLHSIFYKLLFDVLSSPSLTKAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRIC 2779

  Fly   709 V-------ATSTCPQLT--EPLAPLKLRLEGNK--LGQRAHYECPEGFRLDGAWNATCLASGNWS 762
            .       .|..|..:|  .|..|:....:||:  |.....:.|..|:..:||..:.|||||.||
Human  2780 QQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWS 2844

  Fly   763 SPTPTCHAIQCPRLELDDP---HLSLIELNTS-----AWGRAV-FKCQWGFKLTGPAQLDCEPSG 818
            ...|||..|.|     .||   ..|:.:::.|     ::|..| ::|..||.|.|...|.|:..|
Human  2845 DMLPTCRIINC-----TDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDG 2904

  Fly   819 VWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQW 883
            .|..|.|:|.::.|..|.:|.:.::.|.|     .||||:|.:||....:|||.|:.:|..:|.|
Human  2905 TWDRPRPQCLLVSCGHPGSPPHSQMSGDS-----YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHW 2964

  Fly   884 SHSPPFCKSQ----CPYPGDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGR 944
            :.|.|.|...    |..||.|.:|:  .|..::|.|..:...|..|.|  ..|..|| .||.:|.
Human  2965 TGSLPHCSGTSVGVCGDPGIPAHGI--RLGDSFDPGTVMRFSCEAGHV--LRGSSER-TCQANGS 3024

  Fly   945 WSGPMPKC 952
            |||..|:|
Human  3025 WSGSQPEC 3032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
higNP_724773.1 Ig_3 612..696 CDD:464046 21/170 (12%)
PHA02927 705..952 CDD:222943 85/270 (31%)
CSMD2NP_001268885.1 CUB 66..173 CDD:238001
CCP 179..236 CDD:214478
CUB 242..345 CDD:238001
CCP 383..441 CDD:153056
CUB 445..553 CDD:395345
CCP 561..615 CDD:153056
CUB 618..725 CDD:238001
CCP 731..789 CDD:153056
CUB 792..899 CDD:238001
CCP 907..961 CDD:153056
CUB 964..1072 CDD:238001
CCP 1079..1135 CDD:153056
CUB 1138..1245 CDD:238001
CCP 1251..1308 CDD:153056
CUB 1311..1419 CDD:238001
CCP 1425..1482 CDD:153056
CUB 1485..1590 CDD:395345
CCP 1598..1655 CDD:153056
CUB 1659..1766 CDD:238001
CCP 1775..1833 CDD:153056
CUB 1836..1941 CDD:238001
CCP 1949..2005 CDD:153056
CUB 2008..2115 CDD:238001
Sushi 2121..2176 CDD:459664
CUB 2180..2286 CDD:238001
Sushi 2292..2349 CDD:459664
CUB 2357..2463 CDD:238001 24/117 (21%)
PHA02927 <2486..2642 CDD:222943 31/171 (18%)
PHA02927 2609..2850 CDD:222943 40/240 (17%)
PHA02927 2792..3032 CDD:222943 84/254 (33%)
Sushi 3037..3091 CDD:459664
PHA02927 3091..3330 CDD:222943
CCP 3334..3389 CDD:153056
Blue background indicates that the domain is not in the aligned region.

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