Protein Alignment unpg and NKX1-1

DIOPT Version :10

• Sequence 1: NP_477146.1
• Gene: unpg / 35942
• FlyBaseID: FBgn0015561
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 122/471 - (25%)
• Similarity: 158/471 - (33%)
• Gaps: 190/471 - (40%)

  Fly   111 PSSPAGHPAAQQPQAQAQPQP---PPPHPPTHALEKQLP-----PTLPH----PL---DTRFLPF 160
            |.:|...||...|     |||   |.|..|..|.::.:.     |..|.    ||   ||  :|.
Human     6 PEAPGDIPALPPP-----PQPGSGPAPPAPAAAAQEAMDGRAELPAFPRAGAPPLAASDT--VPA 63

  Fly   161 NPAAAGVA-------PTDLSYRRLAELMNQDYVHSLSVHARL------------------QHMAA 200
            .|..||.|       ||..|   :.::::.:..:|......|                  ...||
Human    64 APEGAGAARPAAPLRPTSFS---VLDILDPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAA 125

  Fly   201 AGRMHEDQ-------ANPGMAQLQEPTPPQAHSSPAKS---------------GSHSPMEPALD- 242
            :||....:       |..|........||.| ..|.|:               |.|||...:.|
Human   126 SGRPPRAEELERRALAGAGGVGAAGAEPPNA-GDPFKAGEAETNDTNGYSSGGGGHSPSADSGDE 189

  Fly   243 VGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNG--------------AYTNSDSEDCSDDEG 293
            |..|||     |...:...|.:.|.    .:::|.|              |.|::......|:..
Human   190 VPDDED-----DDEDEAPETEAARG----AEEARGGGGGLGARGSGCQGAAETDASPGATVDEAA 245

  Fly   294 AQSRHE---------GG----GMGGKDSQG-----------NGSSSNS-KSRRRRTAFTSEQLLE 333
            |....|         ||    |..|...||           .||.|.| |.||.|||||.|||:.
Human   246 APGPRENSPVAQGPPGGAAAPGGAGTTPQGTATAAKPKRKRTGSDSKSGKPRRARTAFTYEQLVA 310

  Fly   334 LEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTSGTKIV 398
            ||.:|.|.:|||:.||..:|.||.|:|.||||||||||.|||:...|
Human   311 LENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPG------------------ 357

  Fly   399 VPIPVHVNRFAVRSQHQQLEKMCLSGPKPDLRKKLSAEAIGGFEKFSGSTNASSPSGGPVGLGVG 463
                                                             .:.|:|:||..|.|.|
Human   358 -------------------------------------------------ADTSAPTGGGGGPGPG 373

  Fly   464 VGVGVGVGLGVSTPLS 479
            .|.|.|:..|:| |||
Human   374 AGPGTGLPGGLS-PLS 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeodomain	324..376	CDD:459649	33/51 (65%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		23/80 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		42/193 (22%)
		Homeodomain	297..353	CDD:459649	36/55 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		19/107 (18%)