DRSC/TRiP Functional Genomics Resources

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Protein Alignment unpg and NKX6-1

DIOPT Version :10

Sequence 1:NP_477146.1 Gene:unpg / 35942 FlyBaseID:FBgn0015561 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens


Alignment Length:422 Identity:88/422 - (20%)
Similarity:129/422 - (30%) Gaps:185/422 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MERPALLQNGEIGTMESPTTRLASKPFP--KPFSIESLIANQTPATATPP---------SPPEER 54
            :..|.|.....:..|::|....|..|.|  .|.|..|..::.:|   :||         .||...
Human    17 LSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP---SPPLGTHNPGGLKPPATG 78

  Fly    55 DQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIAGGCYLPS-SPAGHP 118
            .........|:||     |::..|:... |..|.:.             :|.|..||| ||:|..
Human    79 GLSSLGSPPQQLS-----AATPHGINDI-LSRPSMP-------------VASGAALPSASPSGSS 124

  Fly   119 AAQQPQAQAQP-------------------------------QPPPPHPPTHALEKQLPPTLPHP 152
            ::....|.|..                               .||||.|.               
Human   125 SSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPG--------------- 174

  Fly   153 LDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQLQ 217
                 |.|:|:||.||......:.||||..:..:..                      ||:.|  
Human   175 -----LYFSPSAAAVAAVGRYPKPLAELPGRTPIFW----------------------PGVMQ-- 210

  Fly   218 EPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTN 282
              :||                                 ..|..|..:|                 
Human   211 --SPP---------------------------------WRDARLACTP----------------- 223

  Fly   283 SDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLT 347
                           |:|..:..||         .|.:..|..|:.:|:..||:.|...|||:..
Human   224 ---------------HQGSILLDKD---------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGP 264

  Fly   348 ERSQIATSLKLSEVQVKIWFQNRRAKWKRVKA 379
            ||:::|.||.::|.|||:||||||.||::..|
Human   265 ERARLAYSLGMTESQVKVWFQNRRTKWRKKHA 296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unpgNP_477146.1 Homeodomain 324..376 CDD:459649 25/51 (49%)
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 27/118 (23%)
Repressor domain. /evidence=ECO:0000250 102..268 52/298 (17%)
Homeodomain 235..293 CDD:459649 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 1/3 (33%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367
Blue background indicates that the domain is not in the aligned region.

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