Protein Alignment unpg and NKX2-6

DIOPT Version :10

• Sequence 1: NP_477146.1
• Gene: unpg / 35942
• FlyBaseID: FBgn0015561
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 90/351 - (25%)
• Similarity: 123/351 - (35%)
• Gaps: 107/351 - (30%)

  Fly   142 EKQLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHE 206
            |:..|...|||...:           :|.:..|.|:.
Human    22 ERSCPAASPHPRVRK-----------SPENFQYLRMD---------------------------- 47

  Fly   207 DQANPGMAQLQEPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGE 271
                      .||...:.|::....|...     ||     ..|..|..|..:.          |
Human    48 ----------AEPRGSEVHNAGGGGGDRK-----LD-----GSEPPGGPCEAVL----------E 82

  Fly   272 MDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGGK-DSQGNGSSSNSKSRRR---RTAFTSEQLL 332
            ||..|.|  ......:.:...|..:|....|:|.. ||...|.|...|:|:|   |..|:..|:|
Human    83 MDAERMG--EPQPGLNAASPLGGGTRVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVL 145

  Fly   333 ELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAG----LTSHGLGRNGTTS 393
            .|||.|..::|||..||..:|::|:|:..||||||||||.|.||.:..    |..|.|      :
Human   146 ALERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSLELAGHPL------T 204

  Fly   394 GTKIVVPIPVHVNRFAVRSQHQQLEKMCLS-GP-KPDLRKKLSAEAIGGFEKFSGSTNASSPSGG 456
            ..::.||:.|...            |.||. || .|......|| |:..:..:.|.      ||.
Human   205 PRRVAVPVLVRDG------------KPCLGPGPGAPAFPSPYSA-AVSPYSCYGGY------SGA 250

  Fly   457 PVGLGVGV-GVGVGVGLGVSTPLSLA 481
            |.|.|.|. ..|...|....|||:.|
Human   251 PYGAGYGTCYAGAPSGPAPHTPLASA 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unpg	NP_477146.1	Homeodomain	324..376	CDD:459649	26/51 (51%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		33/183 (18%)
		Homeodomain	133..189	CDD:459649	27/55 (49%)